Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62 PEBACN Li-Chun Lisa Tsai, Lei Xie, Kim Dore, Li Xie, Jason C. Del Rio ... The Journal of Biological Chemistry, 2015 | 42 | 2015 |
Synthesis of diverse nitrogen-enriched heterocyclic scaffolds using a suite of tunable one-pot multicomponent reactions G Martinez-Ariza, M Ayaz, F Medda, C Hulme The Journal of Organic Chemistry 79 (11), 5153-5162, 2014 | 36 | 2014 |
Acetyl cyanide as a cyanide source in a tandem catalyst-free modified Groebke-Blackburn-Bienayme [4+1]-cycloaddition-Strecker cascade G Martinez-Ariza, J Nunez-Rios, YS Lee, C Hulme Tetrahedron Letters, 2015 | 31 | 2015 |
(Z)-Stereoselective synthesis of mono- and bis-heterocyclic benzimidazol-2-ones via cascade processes coupled with the Ugi multi-component reaction. Z Xu, G Martinez-Ariza, A Cappelli, SA Robers, C Hulme The Journal of Organic Chemistry, 2015 | 30 | 2015 |
A facile and concise route toward the synthesis of novel imidazo-tetrazolodiazepinones via post-condensation modifications of the Ugi-azide adduct F Medda, G Martinez-Ariza, C Hulme Tetrahedron Letters, 2015 | 26 | 2015 |
o-Phenylenediacetic Acid Anhydride in the Castagnoli–Cushman Reaction: Extending the Product Space to ε-Lactams O Bakulina, D Dar’in, M Krasavin Synlett 28 (10), 1165-1169, 2017 | 25 | 2017 |
One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines G Martinez-Ariza, N McConnell, C Hulme Organic Letters, 2016 | 25 | 2016 |
The Synthesis of Stable, Complex Organocesium Tetramic Acids through the Ugi Reaction and Cesium-Carbonate-Promoted Cascades G Martinez-Ariza, A Muhammad, SA Roberts, WA Rabanal-León, ... Angewdante Chemie International Edition, 2015 | 25 | 2015 |
Small molecule medicinal chemistry: strategies and technologies C Hulme, M Ayaz, G Martinez-Ariza, F Medda, A Shaw, W Czechtizky, ... :, 145, 2015 | 25 | 2015 |
Synthesis of fluorescent heterocycles via a Knoevenagel/[4+ 1]-cycloaddition cascade using acetyl cyanide G Martinez-Ariza, BT Mehari, LAG Pinho, C Foley, K Day, JC Jewett, ... Organic & Biomolecular Chemistry 15 (29), 6076-6079, 2017 | 22 | 2017 |
Recent Advances in Multicomponent Reaction Chemistry C Hulme, M Ayaz, G Martinez-Ariza, F Medda, A Shaw Applications in Small Molecule Drug Discovery, 145-187, 2015 | 21* | 2015 |
A Robust Protocol for the Synthesis of Quinoxalines and 5H-Benzo [e][1, 4] di-azepines via the Acidless Ugi Reaction M Ayaz, G Martinez-Ariza, C Hulme Synlett 25, 1680-1684, 2014 | 21 | 2014 |
Room temperature, metal-free, radical chloroazidation of 1, 6-enynes WW Ying, WT Chen, WH Bao, LH Gao, XY Wang, GP Chen, GP Ge, ... Synlett 29 (12), 1664-1668, 2018 | 14 | 2018 |
Recent advances in allosteric androgen receptor inhibitors for the potential treatment of castration-resistant prostate cancer G Martinez-Ariza, C Hulme Pharmaceutical Patent Analyst, 2015 | 11 | 2015 |
A Tandem [3+ 2] Cycloaddition–Elimination Cascade Reaction to Generate Pyrrolo-[3, 4-c] pyrrole-1, 3-diones G Martinez-Ariza, J Dietrich, F De Moliner, C Hulme Synlett 24 (14), 1801-1804, 2013 | 11 | 2013 |
A simple one-pot 2-step N-1-alkylation of indoles with α-iminoketones toward the expeditious 3-step synthesis of N-1-quinoxaline-indoles G Martinez-Ariza, M Ayaz, C Hulme Tetrahedron letters 54 (49), 6719-6721, 2013 | 7 | 2013 |
Catalyst-Free Synthesis of Aminals from Indole-Derived α, α-Dicyanoolefins HL Cui, Y Shi, HQ Deng, JJ Lei, XJ Xu, X Tian, J Qiao, L Zhou Synlett 30 (02), 167-172, 2019 | 6 | 2019 |
In Small Molecule Medicinal Chemistry 145–187 C Hulme, M Ayaz, G Martinez-Ariza, F Medda, A Shaw John Wiley & Sons, Inc, 2015 | 3 | 2015 |
Crystal structures of N-tert-butyl-3-(4-fluorophenyl)-5-oxo-4-[2-(trifluoromethoxy)phenyl]-2,5-dihydrofuran-2-carboxamide and 4-(2H-1,3-benzodioxol-5-yl)-N-cyclohexyl-5-oxo-3 … S Roberts, G Martinez-Ariza, C Hulme Acta Crystallographica Section E 71, 199-202, 2015 | 1 | 2015 |
2, 4-Diphenyl-6-trifluoromethyl-2, 3-dihydro-1H, 5H-pyrrolo [3, 4-c] pyrrole-1, 3-dione SA Roberts, G Martinez-Ariza, J Dietrich, C Hulme Acta Crystallographica Section E: Structure Reports Online 68 (2), o496-o497, 2012 | 1 | 2012 |