| Checkpoint blockade immunotherapy induces dynamic changes in PD-1− CD8+ tumor-infiltrating T cells S Kurtulus, A Madi, G Escobar, M Klapholz, J Nyman, E Christian, ... Immunity 50 (1), 181-194. e6, 2019 | 498 | 2019 |
| Spatially organized multicellular immune hubs in human colorectal cancer K Pelka, M Hofree, JH Chen, S Sarkizova, JD Pirl, V Jorgji, A Bejnood, ... Cell 184 (18), 4734-4752. e20, 2021 | 299 | 2021 |
| Endogenous glucocorticoid signaling regulates CD8+ T cell differentiation and development of dysfunction in the tumor microenvironment N Acharya, A Madi, H Zhang, M Klapholz, G Escobar, S Dulberg, ... Immunity 53 (3), 658-671. e6, 2020 | 106 | 2020 |
| Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy CA Sabatos-Peyton, J Nevin, A Brock, JD Venable, DJ Tan, N Kassam, ... Oncoimmunology 7 (2), e1385690, 2018 | 104 | 2018 |
| The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade L Cucolo, Q Chen, J Qiu, Y Yu, M Klapholz, KA Budinich, Z Zhang, Y Shao, ... Immunity 55 (4), 671-685. e10, 2022 | 40 | 2022 |
| The bidirectional nature of microbiome-epithelial cell interactions AG Solis, M Klapholz, J Zhao, M Levy Current opinion in microbiology 56, 45-51, 2020 | 31 | 2020 |
| Presence of Tim3+ and PD‐1+ CD8+ T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and distinct clinicopathological features M Klapholz, MG Drage, A Srivastava, AC Anderson The Journal of Pathology 257 (2), 186-197, 2022 | 15 | 2022 |
| The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells AE Baxter, H Huang, JR Giles, Z Chen, JE Wu, S Drury, K Dalton, SL Park, ... Immunity 56 (6), 1320-1340. e10, 2023 | 11 | 2023 |
| Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state JC Beltra, MS Abdel-Hakeem, S Manne, Z Zhang, H Huang, M Kurachi, ... BioRxiv, 2022.10. 03.509766, 2022 | 11 | 2022 |
| Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure JC Beltra, MS Abdel-Hakeem, S Manne, Z Zhang, H Huang, M Kurachi, ... Immunity 56 (12), 2699-2718. e11, 2023 | 10 | 2023 |
| Weak microbial metabolites: a treasure trove for using biomimicry to discover and optimize drugs Z Dvorak, M Klapholz, TP Burris, BP Willing, A Gioiello, R Pellicciari, ... Molecular Pharmacology 98 (4), 343-349, 2020 | 9 | 2020 |
| Durable response and improved CD8 T cell plasticity in lung cancer patients after PD1 blockade and JAK inhibition D Mathew, ME Marmarelis, C Foley, JM Bauml, D Ye, R Ghinnagow, ... medRxiv, 2022.11. 05.22281973, 2022 | 4 | 2022 |
| Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer K Pelka, M Hofree, J Chen, S Sarkizova, JD Pirl, V Jorgji, A Bejnood, ... bioRxiv, 2021.01. 30.426796, 2021 | 3 | 2021 |
| An endogenous glucocorticoid-cytokine signaling circuit promotes CD8+ T cell dysfunction in the tumor microenvironment N Acharya, A Madi, H Zhang, M Klapholz, E Christian, KO Dixon, G Fell, ... bioRxiv, 799759, 2019 | 2 | 2019 |
| 256 The TIGIT/CD226/CD155 axis and the effects of combining PD-1/PD-L1 blockade with TIGIT-targeting antibody therapy in syngeneic murine glioblastoma models P Gokhale, B Iorgulescu, M Klapholz, M Poitras, B Eschle, G Freeman, ... Journal for ImmunoTherapy of Cancer 9 (Suppl 2), 2021 | | 2021 |
| Tumor RIPK1 Signaling Regulates Intrinsic and Extrinsic Mechanisms of Resistance to Immune Checkpoint Blockade Therapy LD Cucolo University of Pennsylvania, 2021 | | 2021 |
| GLUCOCORTICOIDS MEDIATE FAULTY TUMOR-INFILTRATING LYMPHOCYTE FUNCTION N Acharya, A Madi, H Zhang, M Klapholz, G Escobar, S Dulberg CANCER DISCOVERY 10 (11), 1624-1624, 2020 | | 2020 |
| Glucocorticoid signaling regulates CD8+ T cell responses in cancer N Acharya, A Madi, H Zhang, M Klapholz, E Christian, KO Dixon, ... The Journal of Immunology 202 (1_Supplement), 137.15-137.15, 2019 | | 2019 |
| Expression of TIM3 (CD366) and LAG3 (CD223) in Colorectal Carcinoma-associated Inflammatory Infiltrate Suggest Novel Therapeutic Targets for Immune Checkpoint Blockade M Drage, M Klapholz, AC Anderson, A Srivastava LABORATORY INVESTIGATION 98, 259-259, 2018 | | 2018 |
