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Srinath Krishnamurthy
Srinath Krishnamurthy
OMass Therapeutics
Verified email at omass.com
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Year
Architecture of a dsDNA viral capsid in complex with its maturation protease
D Veesler, R Khayat, S Krishnamurthy, J Snijder, RK Huang, AJR Heck, ...
Structure 22 (2), 230-237, 2014
442014
Active site coupling in PDE: PKA complexes promotes resetting of mammalian cAMP signaling
S Krishnamurthy, BS Moorthy, LX Xiang, LX Shan, K Bharatham, ...
Biophysical journal 107 (6), 1426-1440, 2014
372014
Trigger factor is a bona fide secretory pathway chaperone that interacts with SecB and the translocase
J De Geyter, AG Portaliou, B Srinivasu, S Krishnamurthy, A Economou, ...
EMBO reports 21 (6), e49054, 2020
362020
Cyclic AMP-and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RIα) subunits of cyclic AMP-dependent protein kinase
GS Anand, S Krishnamurthy, T Bishnoi, A Kornev, SS Taylor, DA Johnson
Molecular & Cellular Proteomics 9 (10), 2225-2237, 2010
352010
Channeling of cAMP in PDE-PKA complexes promotes signal adaptation
NK Tulsian, S Krishnamurthy, GS Anand
Biophysical journal 112 (12), 2552-2566, 2017
332017
Predicting allosteric effects from orthosteric binding in Hsp90-ligand interactions: implications for fragment-based drug design
A Chandramohan, S Krishnamurthy, A Larsson, P Nordlund, A Jansson, ...
PLoS computational biology 12 (6), e1004840, 2016
332016
Parallel allostery by cAMP and PDE coordinates activation and termination phases in cAMP signaling
S Krishnamurthy, NK Tulsian, A Chandramohan, GS Anand
Biophysical journal 109 (6), 1251-1263, 2015
222015
Probing universal protein dynamics using hydrogen–deuterium exchange mass spectrometry-derived residue-level Gibbs free energy
JH Smit, S Krishnamurthy, BY Srinivasu, R Parakra, S Karamanou, ...
Analytical Chemistry 93 (38), 12840-12847, 2021
192021
β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase
N Ali, N Ling, S Krishnamurthy, JS Oakhill, JW Scott, DI Stapleton, ...
Scientific reports 6 (1), 39417, 2016
192016
A nexus of intrinsic dynamics underlies translocase priming
S Krishnamurthy, N Eleftheriadis, K Karathanou, JH Smit, AG Portaliou, ...
Structure 29 (8), 846-858. e7, 2021
172021
Dynamics of phosphodiesterase-induced cAMP dissociation from protein kinase A: capturing transient ternary complexes by HDXMS
S Krishnamurthy, BS Moorthy, L Liqin, GS Anand
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (6), 1215-1221, 2013
112013
Preproteins couple the intrinsic dynamics of SecA to its ATPase cycle to translocate via a catch and release mechanism
S Krishnamurthy, MF Sardis, N Eleftheriadis, KE Chatzi, JH Smit, ...
Cell reports 38 (6), 2022
102022
Evolutionary adaptation of the protein folding pathway for secretability
D Smets, A Tsirigotaki, JH Smit, S Krishnamurthy, AG Portaliou, ...
The EMBO Journal 41 (23), e111344, 2022
72022
Distinguishing direct binding interactions from allosteric effects in the protease–HK97 prohead I δ domain complex by amide H/D exchange mass spectrometry
S Krishnamurthy, D Veesler, R Khayat, J Snijder, RK Huang, AJR Heck, ...
Bacteriophage 4 (4), e959816, 2014
72014
In-gel staining of proteins in native poly acryl amide gel electrophoresis using tetrakis (4-sulfonato phenyl) porphyrin
K Divakar, V Sujatha, S Barath, K Srinath, P Gautam
Analytical Sciences 27 (1), 101-103, 2011
72011
Hydrogen exchange mass spectrometry experimental design
LC Wang, S Krishnamurthy, GS Anand
Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods, and …, 2016
52016
PyHDX: Derivation and visualization of protection factors from Hydrogen-Deuterium Exchange Mass Spectrometry at near residue resolution
JH Smit, S Krishnamurthy, BY Srinivasu, S Karamanou, A Economou
bioRxiv, 2020.09. 30.320887, 2020
32020
Evolutionary adaptation of the folding pathway for secretability
D Smets, A Tsirigotaki, JH Smit, S Krishnamurthy, AG Portaliou, ...
bioRxiv, 2022.04. 03.486881, 2022
22022
Moderated test statistics to detect differential deuteration in hydrogen/deuterium exchange mass spectrometry experiments
J Claesen, S Krishnamurthy, AM Lau, A Economou
Analytical Chemistry 93 (49), 16341-16349, 2021
22021
Probing universal protein dynamics using residue-level Gibbs free energy
JH Smit, S Krishnamurthy, BY Srinivasu, R Parakra, S Karamanou, ...
12020
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