| Kinase inhibitors: the road ahead FM Ferguson, NS Gray Nature Reviews Drug Discovery, 2018 | 837 | 2018 |
| Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models MC Silva, FM Ferguson, Q Cai, KA Donovan, G Nandi, D Patnaik, T Zhang, ... eLife 8, e45457, 2019 | 211 | 2019 |
| Mapping the degradable kinome provides a resource for expedited degrader development KA Donovan, FM Ferguson, JW Bushman, NA Eleuteri, D Bhunia, SS Ryu, ... Cell 183 (6), 1714-1731. e10, 2020 | 169 | 2020 |
| A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes MGJ Baud, E Lin-Shiao, T Cardote, C Tallant, A Pschibul, KH Chan, ... Science 346 (6209), 638-641, 2014 | 155 | 2014 |
| Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules B Nabet, FM Ferguson, BKA Seong, M Kuljanin, AL Leggett, ML Mohardt, ... Nature communications 11 (1), 4687, 2020 | 135 | 2020 |
| Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain FM Ferguson, O Fedorov, A Chaikuad, M Philpott, JRC Muniz, I Felletar, ... Journal of Medicinal Chemistry 56 (24), 10183-10187, 2013 | 101 | 2013 |
| Discovery of a selective inhibitor of doublecortin like kinase 1 FM Ferguson, B Nabet, S Raghavan, Y Liu, AL Leggett, M Kuljanin, ... Nature Chemical Biology, doi: 10.1038/s41589-020-0506-0, 2020 | 92 | 2020 |
| Selective Mediator dependence of cell-type-specifying transcription MG Jaeger, B Schwalb, SD Mackowiak, T Velychko, A Hanzl, H Imrichova, ... Nature genetics 52 (7), 719-727, 2020 | 87 | 2020 |
| Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC C Tallant, E Valentini, O Fedorov, L Overvoorde, FM Ferguson, ... Structure 23 (1), 80-92, 2015 | 73 | 2015 |
| Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains J Wang, T Erazo, FM Ferguson, DL Buckley, N Gomez, ... ACS Chemical Biology, 2018 | 55 | 2018 |
| TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma BKA Seong, NV Dharia, S Lin, KA Donovan, S Chong, A Robichaud, ... Cancer cell 39 (9), 1262-1278. e7, 2021 | 53 | 2021 |
| Targeting the PI5P4K lipid kinase family in cancer using covalent inhibitors SC Sivakumaren, H Shim, T Zhang, FM Ferguson, MR Lundquist, ... Cell chemical biology 27 (5), 525-537. e6, 2020 | 35 | 2020 |
| Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma B Jiang, J Jiang, IH Kaltheuner, AB Iniguez, K Anand, FM Ferguson, ... European Journal of Medicinal Chemistry 221, 113481, 2021 | 30 | 2021 |
| Binding hotspots of BAZ2B bromodomain: histone interaction revealed by solution NMR driven docking FM Ferguson, DM Dias, JP Rodrigues, H Wienk, R Boelens, AMJJ Bonvin, ... Biochemistry 53 (42), 6706-6716, 2014 | 30 | 2014 |
| Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity FM Ferguson, ZM Doctor, SB Ficarro, CM Browne, JA Marto, JL Johnson, ... Cell Chemical Biology 26, 1-14, 2019 | 24 | 2019 |
| Chemical biology toolkit for DCLK1 reveals connection to RNA processing Y Liu, FM Ferguson, L Li, M Kuljanin, CE Mills, K Subramanian, ... Cell chemical biology 27 (10), 1229-1240. e4, 2020 | 21 | 2020 |
| Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells ALE Carli, S Afshar‐Sterle, A Rai, H Fang, R O'Keefe, J Tse, FM Ferguson, ... Proteomics 21 (13-14), 2000098, 2021 | 19 | 2021 |
| Synthesis and Structure–Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold FM Ferguson, Y Liu, W Harshbarger, L Huang, J Wang, X Deng, ... Journal of medicinal chemistry 63 (14), 7817-7826, 2020 | 19 | 2020 |
| Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors FM Ferguson, J Ni, T Zhang, B Tesar, T Sim, ND Kim, X Deng, JR Brown, ... ACS Medicinal Chemistry Letters, 2016 | 19 | 2016 |
| Discovery and optimization of tau targeted protein degraders enabled by patient induced pluripotent stem cells-derived neuronal models of tauopathy MC Silva, G Nandi, KA Donovan, Q Cai, BC Berry, RP Nowak, ES Fischer, ... Frontiers in Cellular Neuroscience 16, 801179, 2022 | 17 | 2022 |
Alessio CiulliProfessor, University of DundeeVerified email at dundee.ac.uk
