| The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells X Yu, K Harden, L C Gonzalez, M Francesco, E Chiang, B Irving, I Tom, ... Nature immunology 10 (1), 48-57, 2009 | 1401 | 2009 |
| Peripheral T cell expansion predicts tumour infiltration and clinical response TD Wu, S Madireddi, PE de Almeida, R Banchereau, YJJ Chen, AS Chitre, ... Nature 579 (7798), 274-278, 2020 | 512 | 2020 |
| TIGIT: a key inhibitor of the cancer immunity cycle NA Manieri, EY Chiang, JL Grogan Trends in immunology 38 (1), 20-28, 2017 | 363 | 2017 |
| Targeted depletion of lymphotoxin-α–expressing TH1 and TH17 cells inhibits autoimmune disease EY Chiang, GA Kolumam, X Yu, M Francesco, S Ivelja, I Peng, P Gribling, ... Nature medicine 15 (7), 766-773, 2009 | 211 | 2009 |
| Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses KL Banta, X Xu, AS Chitre, A Au-Yeung, C Takahashi, WE O’Gorman, ... Immunity 55 (3), 512-526. e9, 2022 | 160 | 2022 |
| Potassium channels Kv1. 3 and KCa3. 1 cooperatively and compensatorily regulate antigen-specific memory T cell functions EY Chiang, T Li, S Jeet, I Peng, J Zhang, WP Lee, J DeVoss, P Caplazi, ... Nature communications 8 (1), 14644, 2017 | 84 | 2017 |
| Immune complex-mediated cell activation from systemic lupus erythematosus and rheumatoid arthritis patients elaborate different requirements for IRAK1/4 kinase activity across … EY Chiang, X Yu, JL Grogan The Journal of Immunology 186 (2), 1279-1288, 2011 | 82 | 2011 |
| TIGIT-CD226-PVR axis: advancing immune checkpoint blockade for cancer immunotherapy EY Chiang, I Mellman Journal for immunotherapy of cancer 10 (4), 2022 | 78 | 2022 |
| Evaluating the use of antibody variable region (Fv) charge as a risk assessment tool for predicting typical cynomolgus monkey pharmacokinetics DB Yadav, VK Sharma, CA Boswell, I Hotzel, D Tesar, Y Shang, Y Ying, ... Journal of Biological Chemistry 290 (50), 29732-29741, 2015 | 74 | 2015 |
| Regulatory T cell modulation by CBP/EP300 bromodomain inhibition S Ghosh, A Taylor, M Chin, HR Huang, AR Conery, JA Mertz, A Salmeron, ... Journal of Biological Chemistry 291 (25), 13014-13027, 2016 | 70 | 2016 |
| CD96 functions as a co‐stimulatory receptor to enhance CD8+ T cell activation and effector responses EY Chiang, PE de Almeida, DE de Almeida Nagata, KH Bowles, X Du, ... European journal of immunology 50 (6), 891-902, 2020 | 64 | 2020 |
| The nonclassical major histocompatibility complex molecule Qa-2 protects tumor cells from NK cell-and lymphokine-activated killer cell-mediated cytolysis EY Chiang, M Henson, I Stroynowski The Journal of Immunology 168 (5), 2200-2211, 2002 | 64 | 2002 |
| A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155 B Husain, SR Ramani, E Chiang, I Lehoux, S Paduchuri, TA Arena, ... Molecular & Cellular Proteomics 18 (11), 2310-2323, 2019 | 62 | 2019 |
| Lymphotoxin-αβ heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis J Young, X Yu, K Wolslegel, A Nguyen, C Kung, E Chiang, G Kolumam, ... Cytokine 51 (1), 78-86, 2010 | 61 | 2010 |
| Expression of a Nonclassical Mhc Class Ib Molecule In The Eye1 JY Niederkorn, EY Chiang, T Ungchusri, I Stroynowski Transplantation 68 (11), 1790-1799, 1999 | 61 | 1999 |
| High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE T Li, G Lu, EY Chiang, T Chernov-Rogan, JL Grogan, J Chen PLoS One 12 (7), e0180154, 2017 | 53 | 2017 |
| CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1 X Du, P de Almeida, N Manieri, D de Almeida Nagata, TD Wu, ... Proceedings of the National Academy of Sciences 115 (50), E11731-E11740, 2018 | 48 | 2018 |
| Regulation of tumor-associated myeloid cell activity by CBP/EP300 bromodomain modulation of H3K27 acetylation DE de Almeida Nagata, EY Chiang, S Jhunjhunwala, P Caplazi, ... Cell Reports 27 (1), 269-281. e4, 2019 | 47 | 2019 |
| Dimerization of LTβR by LTα1β2 is necessary and sufficient for signal transduction J Sudhamsu, JP Yin, EY Chiang, MA Starovasnik, JL Grogan, ... Proceedings of the National Academy of Sciences 110 (49), 19896-19901, 2013 | 45 | 2013 |
| Correction of defects responsible for impaired Qa-2 class Ib MHC expression on melanoma cells protects mice from tumor growth EY Chiang, M Henson, I Stroynowski The Journal of Immunology 170 (9), 4515-4523, 2003 | 45 | 2003 |
