| The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. T Schwecke, JF Aparicio, I Molnar, A König, LE Khaw, SF Haydock, ... Proceedings of the National Academy of Sciences 92 (17), 7839-7843, 1995 | 613 | 1995 |
| Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase JF Aparicio, I Molnár, T Schwecke, A König, SF Haydock, LE Khaw, ... Gene 169 (1), 9-16, 1996 | 335 | 1996 |
| Divergent sequence motifs correlated with the substrate specificity of (methyl) malonyl‐CoA: acyl carrier protein transacylase domains in modular polyketide synthases SF Haydock, JF Aparicio, I Molnár, T Schwecke, LE Khaw, A König, ... FEBS letters 374 (2), 246-248, 1995 | 300 | 1995 |
| Stereospecific acyl transfers on the erythromycin-producing polyketide synthase AFA Marsden, P Caffrey, JF Aparicio, MS Loughran, J Staunton, ... Science 263 (5145), 378-380, 1994 | 210 | 1994 |
| A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis JF Aparicio, R Fouces, MV Mendes, N Olivera, JF Martı́n Chemistry & biology 7 (11), 895-905, 2000 | 200 | 2000 |
| Polyene antibiotic biosynthesis gene clusters JF Aparicio, P Caffrey, JA Gil, SB Zotchev Applied microbiology and biotechnology 61, 179-188, 2003 | 190 | 2003 |
| Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase I Molnár, JF Aparicio, SF Haydock, LE Khaw, T Schwecke, A König, ... Gene 169 (1), 1-7, 1996 | 188 | 1996 |
| Evidence for a double-helical structure for modular polyketide synthases J Staunton, P Caffrey, JF Aparicio, GA Roberts, SS Bethell, PF Leadlay Nature structural biology 3 (2), 188-192, 1996 | 182 | 1996 |
| The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin: a new polyketide synthase organization encoded by two subclusters separated by … JF Aparicio, AJ Colina, E Ceballos, JF Martın Journal of Biological Chemistry 274 (15), 10133-10139, 1999 | 150 | 1999 |
| PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis N Anton, J Santos-Aberturas, MV Mendes, SM Guerra, JF Martín, ... Microbiology 153 (9), 3174-3183, 2007 | 134 | 2007 |
| PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis E Recio, A Colinas, A Rumbero, JF Aparicio, JF Martín Journal of Biological Chemistry 279 (40), 41586-41593, 2004 | 131 | 2004 |
| Identification of PimR as a Positive Regulator of Pimaricin Biosynthesis in Streptomyces natalensis N Antón, MV Mendes, JF Martín, JF Aparicio Journal of bacteriology 186 (9), 2567-2575, 2004 | 129 | 2004 |
| Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis MV Mendes, E Recio, R Fouces, R Luiten, JF Martı́n, JF Aparicio Chemistry & Biology 8 (7), 635-644, 2001 | 123 | 2001 |
| The two-component phoR-phoP system of Streptomyces natalensis: inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis MV Mendes, S Tunca, N Antón, E Recio, A Sola-Landa, JF Aparicio, ... Metabolic engineering 9 (2), 217-227, 2007 | 117 | 2007 |
| Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase. JF Aparicio, P Caffrey, AF Marsden, J Staunton, PF Leadlay Journal of Biological Chemistry 269 (11), 8524-8528, 1994 | 115 | 1994 |
| Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation JF Aparicio, EG Barreales, TD Payero, CM Vicente, A de Pedro, ... Applied microbiology and biotechnology 100 (1), 61-78, 2016 | 112 | 2016 |
| Polyene macrolide antibiotic biosynthesis JF Aparicio, MV Mendes, N Antón, E Recio, JF Martin Current medicinal chemistry 11 (12), 1643-1656, 2004 | 103 | 2004 |
| Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents P Caffrey, JF Aparicio, F Malpartida, SB Zotchev Current topics in medicinal chemistry 8 (8), 639-653, 2008 | 102 | 2008 |
| Functional analysis of pneumolysin by use of monoclonal antibodies JR de los Toyos, FJ Méndez, JF Aparicio, F Vazquez, ... Infection and immunity 64 (2), 480-484, 1996 | 83 | 1996 |
| Cholesterol oxidases act as signaling proteins for the biosynthesis of the polyene macrolide pimaricin MV Mendes, E Recio, N Antón, SM Guerra, J Santos-Aberturas, JF Martín, ... Chemistry & biology 14 (3), 279-290, 2007 | 82 | 2007 |
Javier Santos AberturasPostdoctoral Researcher, John Innes CentreVerified email at unileon.es
