| Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo BA Spruce, LA Campbell, N McTavish, MA Cooper, MVL Appleyard, ... Cancer research 64 (14), 4875-4886, 2004 | 224 | 2004 |
| Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates D Komander, A Fairservice, M Deak, GS Kular, AR Prescott, ... The EMBO journal 23 (20), 3918-3928, 2004 | 211 | 2004 |
| A novel context for the ‘MutT’module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase ST Safrany, JJ Caffrey, X Yang, ME Bembenek, MB Moyer, WA Burkhart, ... The EMBO journal, 1998 | 184 | 1998 |
| The Diadenosine Hexaphosphate Hydrolases fromSchizosaccharomyces pombe and Saccharomyces cerevisiae Are Homologues of the Human Diphosphoinositol Polyphosphate Phosphohydrolase … ST Safrany, SW Ingram, JL Cartwright, JR Falck, AG McLennan, ... Journal of Biological Chemistry 274 (31), 21735-21740, 1999 | 143 | 1999 |
| Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase A CRAXTON, JJ CAFFREY, W BURKHART, TS SAFRANY, BS SHEARS Biochemical Journal 328 (1), 75-81, 1997 | 120 | 1997 |
| Differential redox regulation within the PTP superfamily SH Ross, Y Lindsay, ST Safrany, O Lorenzo, F Villa, R Toth, MJ Clague, ... Cellular signalling 19 (7), 1521-1530, 2007 | 116 | 2007 |
| Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells C Albert, TS SAFRANY, EM BEMBENEK, KM Reddy, KK Reddy, JR Falck, ... Biochemical Journal 327 (2), 553-560, 1997 | 104 | 1997 |
| Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases: an expanding NUDT family JJ Caffrey, ST Safrany, X Yang, SB Shears Journal of Biological Chemistry 275 (17), 12730-12736, 2000 | 100 | 2000 |
| Interaction of synthetic D‐6‐deoxy‐myo‐inositol 1,4,5‐trisphosphate with the Ca2+‐releasing D‐myo‐inositol 1,4,5‐trisphosphate receptor, and the metabolic … ST Safrany, RJH Wojcikiewicz, J Strupish, SR Nahorski, D Dubreuil, ... FEBS letters 278 (2), 252-256, 1991 | 75 | 1991 |
| Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs RS Kilari, JD Weaver, SB Shears, ST Safrany FEBS letters 587 (21), 3464-3470, 2013 | 70 | 2013 |
| Turnover of bis-diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by β2-adrenergic receptors through a cAMP-mediated, A-kinase-independent mechanism ST Safrany, SB Shears The EMBO journal 17 (6), 1710-1716, 1998 | 68 | 1998 |
| Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the … DI Fisher, ST Safrany, P Strike, AG McLennan, JL Cartwright Journal of Biological Chemistry 277 (49), 47313-47317, 2002 | 66 | 2002 |
| 3-position modification of myo-inositol 1, 4, 5-trisphosphate: consequences for intracellular Ca2+ mobilisation and enzyme recognition ST Safrany, RA Wilcox, C Liu, BVL Potter, SR Nahorski European Journal of Pharmacology: Molecular Pharmacology 226 (3), 265-272, 1992 | 65 | 1992 |
| Diphosphoinositol polyphosphates: the final frontier for inositide research? ST Safrany, JJ Caffrey, X Yang, SB Shears Walter de Gruyter 380 (7-8), 945-951, 1999 | 60 | 1999 |
| Synthetic phosphorothioate-containing analogues of inositol 1, 4, 5-trisphosphate mobilize intracellular Ca2+ stores and interact differentially with inositol 1, 4, 5 … ST Safrany, RJ Wojcikiewicz, J Strupish, J McBain, AM Cooke, BV Potter, ... Molecular pharmacology 39 (6), 754-761, 1991 | 59 | 1991 |
| Modification at C2 of myo‐inositol 1,4,5‐trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities RA Wilcox, ST Safrany, D Lampe, SJ Mills, SR Nahorski, BVL Potter European journal of biochemistry 223 (1), 115-124, 1994 | 58 | 1994 |
| Visualization of inositol phosphate‐dependent mobility of Ku: depletion of the DNA–PK cofactor InsP6 inhibits Ku mobility J Byrum, S Jordan, ST Safrany, W Rodgers Nucleic acids research 32 (9), 2776-2784, 2004 | 55 | 2004 |
| A novel mechanism for the anticancer activity of aspirin and salicylates AIJ Bashir, CS Kankipati, S Jones, RM Newman, ST Safrany, CJ Perry, ... International journal of oncology 54 (4), 1256-1270, 2019 | 50 | 2019 |
| Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol … X Yang, ST Safrany, SB Shears Journal of Biological Chemistry 274 (50), 35434-35440, 1999 | 49 | 1999 |
| The edge effect: A global problem. The trouble with culturing cells in 96-well plates M Mansoury, M Hamed, R Karmustaji, F Al Hannan, ST Safrany Biochemistry and biophysics reports 26, 100987, 2021 | 48 | 2021 |
