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Pok Man Lai
Pok Man Lai
Verified email at connect.hku.hk
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Year
Characterization of the lipidomic profile of human coronavirus-infected cells: implications for lipid metabolism remodeling upon coronavirus replication
B Yan, H Chu, D Yang, KH Sze, PM Lai, S Yuan, H Shuai, Y Wang, ...
Viruses 11 (1), 73, 2019
2592019
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
S Yuan, H Chu, JFW Chan, ZW Ye, L Wen, B Yan, PM Lai, KM Tee, ...
Nature communications 10 (1), 120, 2019
2322019
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
S Yuan, X Yin, X Meng, JFW Chan, ZW Ye, L Riva, L Pache, CCY Chan, ...
Nature 593 (7859), 418-423, 2021
1812021
Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target
S Yuan, H Chu, J Huang, X Zhao, ZW Ye, PM Lai, L Wen, JP Cai, Y Mo, ...
Science advances 6 (35), eaba7910, 2020
522020
Lipidomic profiling reveals significant perturbations of intracellular lipid homeostasis in enterovirus-infected cells
B Yan, Z Zou, H Chu, G Chan, JOL Tsang, PM Lai, S Yuan, CCY Yip, ...
International journal of molecular sciences 20 (23), 5952, 2019
372019
Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication. Viruses 2019, 11, 73
B Yan, H Chu, D Yang, KH Sze, PM Lai, S Yuan, H Shuai, Y Wang, ...
DOI: https://doi. org/10.3390/v11010073. PMID: https://www. ncbi. nlm. nih …, 0
29
Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine‐membered enediyne C‐1027
X Chen, ZF Guo, PM Lai, KH Sze, Z Guo
Angewandte Chemie 43 (122), 8098-8100, 2010
182010
Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters
S Yuan, X Yin, XZ Meng, J Chan, ZW Ye, L Riva, L Pache, CCY Chan, ...
Research square, 2020
162020
Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts
WH Lam, KH Sze, Y Ke, MK Tse, H Zhang, PCY Woo, SKP Lau, CCY Lau, ...
Infection and Immunity 87 (4), 10.1128/iai. 00679-18, 2019
142019
Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway
B Yan, S Yuan, J Cao, K Fung, PM Lai, F Yin, KH Sze, Z Qin, Y Xie, ZW Ye, ...
International Journal of Biological Sciences 18 (12), 4744, 2022
122022
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target. Nat Commun 10: 120
S Yuan, H Chu, JFW Chan, ZW Ye, L Wen, B Yan, PM Lai, KM Tee, ...
102019
Characterization of the lipidomic profile of human coronavirus-infected cells: implications for lipid metabolism remodeling upon coronavirus replication. Viruses 11 (1): 73
B Yan, H Chu, D Yang, KH Sze, PM Lai, S Yuan, H Shuai, Y Wang, ...
72019
Probing protein dynamics by nuclear magnetic resonance
K Hung Sze, P Man Lai
Protein and peptide letters 18 (4), 373-379, 2011
52011
Linoleic acid metabolism activation in macrophages promotes the clearing of intracellular Staphylococcus aureus
B Yan, K Fung, S Ye, PM Lai, YX Wei, KH Sze, D Yang, P Gao, RYT Kao
Chemical Science 13 (42), 12445-12460, 2022
42022
SaeR as a novel target for antivirulence therapy against Staphylococcus aureus
P Gao, Y Wei, S Hou, PM Lai, H Liu, SSC Tai, VYM Tang, PH Prakash, ...
Emerging Microbes & Infections 12 (2), 2254415, 2023
22023
Identification of a Small Molecule Compound Active against Antibiotic-Tolerant Staphylococcus aureus by Boosting ATP Synthesis
HTV Iu, PM Fong, HCB Yam, P Gao, B Yan, PM Lai, VYM Tang, KH Li, ...
International Journal of Molecular Sciences 24 (7), 6242, 2023
2023
In Silico Structure-Based Screening of Large Ligand Library Against Virulence Factors of Drug Resistant Pathogens
TTM Yung, PM Lai, T Zhou, MK Tse, RYT Kao, KY Yuen, KH Sze
Biomedical Journal of Scientific & Technical Research 18 (5), 13848-13854B, 2019
2019
Structure determination of N-terminal peptide of nucleoprotein (NP20) of influenza virus H5N1 by nuclear magnetic resonance spectroscopy
P Lai
HKU Theses Online (HKUTO), 2013
2013
Characterization of a nonaketide precursor in biosynthesis of the nine-membered enediyne core of the antitumor antibiotic C-1027
X Chen, ZF Guo, PM Lai, KH Sze, Z Guo
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, 2010
2010
Structure And Functional Study of N-terminal of Nucleoprotein (NP-20)
PM Lai, PC Shaw, KH Sze
Symposium on Chemistry Postgraduate Research in Hong Kong, 2009
2009
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