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Rhianna J. Rowland
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Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes
SP Schröder, C De Boer, NGS McGregor, RJ Rowland, O Moroz, ...
ACS central science 5 (6), 1067-1078, 2019
482019
Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish
M Artola, CL Kuo, LT Lelieveld, RJ Rowland, GA van der Marel, ...
Journal of the American Chemical Society 141 (10), 4214-4218, 2019
372019
α-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal α-galactosidase A in Fabry disease
M Artola, C Hedberg, RJ Rowland, L Raich, K Kytidou, L Wu, A Schaaf, ...
Chemical Science 10 (40), 9233-9243, 2019
172019
A baculoviral system for the production of human β-glucocerebrosidase enables atomic resolution analysis
RJ Rowland, L Wu, F Liu, GJ Davies
Acta Crystallographica Section D: Structural Biology 76 (6), 565-580, 2020
82020
Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents
RJ Rowland, Y Chen, I Breen, L Wu, WA Offen, TJM Beenakker, Q Su, ...
Chemistry-a European Journal 27, 16377-16388, 2021
72021
Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
RJ Rowland, R Heath, D Maskell, RF Thompson, NA Ranson, JN Blaza, ...
Scientific reports 13 (1), 10718, 2023
32023
Cryo-EM structure of the CDK2-cyclin A-CDC25A complex
RJ Rowland, S Korolchuk, M Salamina, JR Ault, S Hart, JP Turkenberg, ...
bioRxiv, 2023.10. 17.562665, 2023
2023
Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha-and beta-glucosidases
D van der Gracht, RJ Rowland, V Roig-Zamboni, MJ Ferraz, M Louwerse, ...
Chemical Science 14 (34), 9136-9144, 2023
2023
Structural and functional characterisation of human lysosomal glycoside hydrolases: insights into lysosomal storage disorders
RJ Rowland
University of York, 2021
2021
Pharmacological modulation of glycosidases in zebrafish
CL Kuo, WW Kallemeijn, LT Lelieveld, M Mirzaian, I Zoutendijk, A Vardi, ...
FEBS J 286 (3), 584-600, 2019
2019
Synthesis and Biochemical Evaluation of Bifunctional Cyclophellitol Aziridines as Selective GBA Inhibitors and Activity-Based Probes
RJ Rowland, Y Chen, I Breen, L Wu, WA Offen, TJ Beenakker, Q Su, ...
Exploring chemical space in covalent and competitive glycosidase inhibitor …, 0
Activity-based probes targeting glycosidases acting on plant glycans
SP Schröder, C de Boer, NGS McGregor, RJ Rowland, O Moroz, ...
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