| The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine SDC Griffin, LP Beales, DS Clarke, O Worsfold, SD Evans, J Jaeger, ... FEBS letters 535 (1-3), 34-38, 2003 | 715 | 2003 |
| Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade A Samson, KJ Scott, D Taggart, EJ West, E Wilson, GJ Nuovo, S Thomson, ... Science translational medicine 10 (422), eaam7577, 2018 | 365 | 2018 |
| Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production AL Wozniak, S Griffin, D Rowlands, M Harris, MK Yi, SM Lemon, ... PLoS pathogens 6 (9), e1001087, 2010 | 245 | 2010 |
| A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to … SDC Griffin, R Harvey, DS Clarke, WS Barclay, M Harris, DJ Rowlands Journal of General Virology 85 (2), 451-461, 2004 | 227 | 2004 |
| Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro D Clarke, S Griffin, L Beales, CS Gelais, S Burgess, M Harris, D Rowlands Journal of Biological Chemistry 281 (48), 37057-37068, 2006 | 183 | 2006 |
| Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase J Mankouri, PR Tedbury, S Gretton, ME Hughes, SDC Griffin, ML Dallas, ... Proceedings of the National Academy of Sciences 107 (25), 11549-11554, 2010 | 167 | 2010 |
| Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel S Griffin, C StGelais, AM Owsianka, AH Patel, D Rowlands, M Harris Hepatology 48 (6), 1779-1790, 2008 | 153 | 2008 |
| Viroporins: structure, function and potential as antiviral targets C Scott, S Griffin Journal of General Virology 96 (8), 2000-2027, 2015 | 140 | 2015 |
| Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particles L Corless, CM Crump, SDC Griffin, M Harris Journal of General Virology 91 (2), 362-372, 2010 | 138 | 2010 |
| High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors LF Wetherill, KK Holmes, M Verow, M Müller, G Howell, M Harris, ... Journal of virology 86 (9), 5341-5351, 2012 | 134 | 2012 |
| Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles M Hughes, S Griffin, M Harris Journal of general virology 90 (6), 1329-1334, 2009 | 129 | 2009 |
| Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes S Griffin, D Clarke, C McCormick, D Rowlands, M Harris Journal of virology 79 (24), 15525-15536, 2005 | 121 | 2005 |
| The major human immunodeficiency virus type 2 (HIV-2) packaging signal is present on all HIV-2 RNA species: cotranslational RNA encapsidation and limitation of Gag protein … SDC Griffin, JF Allen, AML Lever Journal of virology 75 (24), 12058-12069, 2001 | 111 | 2001 |
| Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability SD Carter, KC Dent, E Atkins, TL Foster, M Verow, P Gorny, M Harris, ... FEBS letters 584 (13), 2786-2790, 2010 | 107 | 2010 |
| Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system C StGelais, TJ Tuthill, DS Clarke, DJ Rowlands, M Harris, S Griffin Antiviral research 76 (1), 48-58, 2007 | 100 | 2007 |
| Internalization of oncolytic reovirus by human dendritic cell carriers protects the virus from neutralization EJ Ilett, M Bárcena, F Errington-Mais, S Griffin, KJ Harrington, HS Pandha, ... Clinical Cancer Research 17 (9), 2767-2776, 2011 | 99 | 2011 |
| Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro C StGelais, TL Foster, M Verow, E Atkins, CWG Fishwick, D Rowlands, ... Journal of virology 83 (16), 7970-7981, 2009 | 88 | 2009 |
| Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation AA Negash, RM Olson, S Griffin, M Gale Jr PLoS Pathogens 15 (2), e1007593, 2019 | 86 | 2019 |
| Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel TL Foster, M Verow, AL Wozniak, MJ Bentham, J Thompson, E Atkins, ... Hepatology 54 (1), 79-90, 2011 | 86 | 2011 |
| Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence J Mankouri, ML Dallas, ME Hughes, SDC Griffin, A Macdonald, C Peers, ... Proceedings of the National Academy of Sciences 106 (37), 15903-15908, 2009 | 78 | 2009 |
Mark HarrisProfessor of Virology, University of LeedsVerified email at leeds.ac.uk
