Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways LJ Drury, JJ Ziarek, S Gravel, CT Veldkamp, T Takekoshi, ST Hwang, ... Proceedings of the National Academy of Sciences 108 (43), 17655-17660, 2011 | 260 | 2011 |
Structure-based ligand discovery for the protein–protein interface of chemokine receptor CXCR4 MM Mysinger, DR Weiss, JJ Ziarek, S Gravel, AK Doak, J Karpiak, ... Proceedings of the National Academy of Sciences 109 (14), 5517-5522, 2012 | 167 | 2012 |
New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model AB Kleist, AE Getschman, JJ Ziarek, AM Nevins, PA Gauthier, A Chevigné, ... Biochemical pharmacology 114, 53-68, 2016 | 140 | 2016 |
The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions V Saini, DM Staren, JJ Ziarek, ZN Nashaat, EM Campbell, BF Volkman, ... Journal of Biological Chemistry 286 (38), 33466-33477, 2011 | 106 | 2011 |
Monomeric structure of the cardioprotective chemokine SDF‐1/CXCL12 CT Veldkamp, JJ Ziarek, J Su, H Basnet, R Lennertz, JJ Weiner, ... Protein Science 18 (7), 1359-1369, 2009 | 106 | 2009 |
Binding site identification and structure determination of protein–ligand complexes by NMR: a semiautomated approach JJ Ziarek, FC Peterson, BL Lytle, BF Volkman Methods in enzymology 493, 241-275, 2011 | 99 | 2011 |
Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and … JJ Ziarek, CT Veldkamp, F Zhang, NJ Murray, GA Kartz, X Liang, J Su, ... Journal of Biological Chemistry 288 (1), 737-746, 2013 | 94 | 2013 |
Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation JJ Ziarek, AB Kleist, N London, B Raveh, N Montpas, J Bonneterre, ... Science signaling 10 (471), eaah5756, 2017 | 88 | 2017 |
A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability T Takekoshi, JJ Ziarek, BF Volkman, ST Hwang Molecular cancer therapeutics 11 (11), 2516-2525, 2012 | 74 | 2012 |
Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design CT Veldkamp, JJ Ziarek, FC Peterson, Y Chen, BF Volkman Journal of the American Chemical Society 132 (21), 7242-7243, 2010 | 74 | 2010 |
Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery JJ Ziarek, AE Getschman, SJ Butler, D Taleski, B Stephens, I Kufareva, ... ACS chemical biology 8 (9), 1955-1963, 2013 | 69 | 2013 |
Solution structure of CCL21 and identification of a putative CCR7 binding site M Love, JL Sandberg, JJ Ziarek, KP Gerarden, RR Rode, DR Jensen, ... Biochemistry 51 (3), 733-735, 2012 | 62 | 2012 |
15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins S Chhabra, P Fischer, K Takeuchi, A Dubey, JJ Ziarek, A Boeszoermenyi, ... Proceedings of the National Academy of Sciences 115 (8), E1710-E1719, 2018 | 58 | 2018 |
Discovery and Characterization of a Disulfide-Locked C2-Symmetric Defensin Peptide AJ Wommack, JJ Ziarek, J Tomaras, HR Chileveru, Y Zhang, G Wagner, ... Journal of the American Chemical Society 136 (39), 13494-13497, 2014 | 57 | 2014 |
Biased antagonism of CXCR4 avoids antagonist tolerance B Hitchinson, JM Eby, X Gao, F Guite-Vinet, JJ Ziarek, H Abdelkarim, ... Science signaling 11 (552), eaat2214, 2018 | 45 | 2018 |
Chemokine cooperativity is caused by competitive glycosaminoglycan binding F Verkaar, J Van Offenbeek, M van der Lee, LHCJ Van Lith, AO Watts, ... The Journal of Immunology 192 (8), 3908-3914, 2014 | 43 | 2014 |
Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction J J Ziarek, Y Liu, E Smith, G Zhang, F C Peterson, J Chen, Y Yu, Y Chen, ... Current topics in medicinal chemistry 12 (24), 2727-2740, 2012 | 40 | 2012 |
Seasonal adaptations of Daphnia pulicaria swimming behaviour: the effect of water temperature JJ Ziarek, A Nihongi, T Nagai, M Uttieri, JR Strickler Hydrobiologia 661, 317-327, 2011 | 38 | 2011 |
Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology JJ Ziarek, D Baptista, G Wagner Journal of Molecular Medicine 96, 1-8, 2018 | 36 | 2018 |
Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine EW Smith, Y Liu, AE Getschman, FC Peterson, JJ Ziarek, R Li, ... Journal of medicinal chemistry 57 (22), 9693-9699, 2014 | 33 | 2014 |