Drugs in development for toxoplasmosis: advances, challenges, and current status PH Alday, JS Doggett Drug design, development and therapy, 273-293, 2017 | 297 | 2017 |
Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis JS Doggett, A Nilsen, I Forquer, KW Wegmann, L Jones-Brando, ... Proceedings of the National Academy of Sciences 109 (39), 15936-15941, 2012 | 196 | 2012 |
Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers A Nilsen, GP Miley, IP Forquer, MW Mather, K Katneni, Y Li, S Pou, ... Journal of medicinal chemistry 57 (9), 3818-3834, 2014 | 125 | 2014 |
Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with … RSR Vidadala, KL Rivas, KK Ojo, MA Hulverson, JA Zambriski, I Bruzual, ... Journal of medicinal chemistry 59 (13), 6531-6546, 2016 | 90 | 2016 |
Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone LA Lawres, A Garg, V Kumar, I Bruzual, IP Forquer, I Renard, AZ Virji, ... Journal of Experimental Medicine 213 (7), 1307-1318, 2016 | 85 | 2016 |
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance LA Kirkman, W Zhan, J Visone, A Dziedziech, PK Singh, H Fan, X Tong, ... Proceedings of the National Academy of Sciences 115 (29), E6863-E6870, 2018 | 80 | 2018 |
Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection JS Doggett, KK Ojo, E Fan, DJ Maly, WC Van Voorhis Antimicrobial agents and chemotherapy 58 (6), 3547-3549, 2014 | 68 | 2014 |
Extended-spectrum antiprotozoal bumped kinase inhibitors: a review WC Van Voorhis, JS Doggett, M Parsons, MA Hulverson, R Choi, ... Experimental parasitology 180, 71-83, 2017 | 57 | 2017 |
Cystic Neutrophilic Granulomatous Mastitis: Association With Gram-Positive Bacilli and Corynebacterium ML Troxell, NT Gordon, JS Doggett, M Ballard, JT Vetto, RF Pommier, ... American journal of clinical pathology 145 (5), 635-645, 2016 | 56 | 2016 |
Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii PH Alday, I Bruzual, A Nilsen, S Pou, R Winter, C Ben Mamoun, ... Antimicrobial agents and chemotherapy 61 (2), 10.1128/aac. 01866-16, 2017 | 51 | 2017 |
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned R Choi, MA Hulverson, W Huang, RSR Vidadala, GR Whitman, LK Barrett, ... International journal for parasitology 50 (5), 413-422, 2020 | 40 | 2020 |
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1 W Huang, KK Ojo, Z Zhang, K Rivas, RSR Vidadala, S Scheele, ... ACS medicinal chemistry letters 6 (12), 1184-1189, 2015 | 37 | 2015 |
Sontochin as a guide to the development of drugs against chloroquine-resistant malaria S Pou, RW Winter, A Nilsen, JX Kelly, Y Li, JS Doggett, EW Riscoe, ... Antimicrobial agents and chemotherapy 56 (7), 3475-3480, 2012 | 36 | 2012 |
Targeted structure–activity analysis of endochin-like quinolones reveals potent qi and qo site inhibitors of toxoplasma gondii and plasmodium falciparum cytochrome bc 1 and … EV McConnell, I Bruzual, S Pou, R Winter, RA Dodean, MJ Smilkstein, ... ACS infectious diseases 4 (11), 1574-1584, 2018 | 35 | 2018 |
Disseminated Mycobacterium genavense with pulmonary nodules in a kidney transplant recipient: case report and review of the literature JS Doggett, L Strasfeld Transplant Infectious Disease 13 (1), 38-43, 2011 | 34 | 2011 |
Orally bioavailable endochin-like quinolone carbonate ester prodrug reduces Toxoplasma gondii brain cysts JS Doggett, T Schultz, AJ Miller, I Bruzual, S Pou, R Winter, R Dodean, ... Antimicrobial agents and chemotherapy 64 (9), 10.1128/aac. 00535-20, 2020 | 23 | 2020 |
Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection JE Chiu, I Renard, AC Pal, P Singh, P Vydyam, J Thekkiniath, M Kumar, ... Antimicrobial agents and chemotherapy 65 (9), 10.1128/aac. 00662-21, 2021 | 22 | 2021 |
A novel fragmented mitochondrial genome in the protist pathogen Toxoplasma gondii and related tissue coccidia S Namasivayam, RP Baptista, W Xiao, EM Hall, JS Doggett, K Troell, ... Genome Research 31 (5), 852-865, 2021 | 21 | 2021 |
The need for antiviral drugs for pandemic coronaviruses from a global health perspective AH Villamagna, SJ Gore, JS Lewis, JS Doggett Frontiers in Medicine 7, 596587, 2020 | 21 | 2020 |
Efficacy of guanabenz combination therapy against chronic toxoplasmosis across multiple mouse strains J Martynowicz, JS Doggett, WJ Sullivan Jr Antimicrobial agents and chemotherapy 64 (9), 10.1128/aac. 00539-20, 2020 | 21 | 2020 |