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Aaron Hardin
Aaron Hardin
Guardant Health
Verified email at guardanthealth.com - Homepage
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Cited by
Cited by
Year
CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency
N Matharu, S Rattanasopha, S Tamura, L Maliskova, Y Wang, A Bernard, ...
Science 363 (6424), eaau0629, 2019
2682019
Routine Plasma-Based Genotyping to Comprehensively Detect Germline, Somatic, and Reversion BRCA Mutations among Patients with Advanced Solid Tumors
N Vidula, TA Rich, O Sartor, J Yen, A Hardin, T Nance, MB Lilly, ...
Clinical Cancer Research 26 (11), 2546-2555, 2020
402020
Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers
Y Kobayashi, C Chhoeu, J Li, KS Price, LA Kiedrowski, JL Hutchins, ...
Nature 603 (7900), 335-342, 2022
282022
Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha
A Hardin, KA Nevonen, WL Eckalbar, L Carbone, N Ahituv
Molecular biology and evolution 36 (12), 2805-2812, 2019
112019
Clinical utility of microsatellite instability (MSI-H) identified on liquid biopsy in advanced gastrointestinal cancers (aGI).
PM Kasi, SJ Klempner, JS Starr, A Shergill, LA Bucheit, C Weipert, J Liao, ...
Journal of Clinical Oncology 40 (4_suppl), 56-56, 2022
62022
Spectrum of FGFR2/3 alterations in cell-free DNA of patients with advanced urothelial carcinoma
P Grivas, LA Kiedrowski, GP Sonpavde, SV Gupta, RA Thomas, ...
Bladder Cancer 7 (2), 143-148, 2021
32021
A molecular characterization of spontaneous frameshift mutagenesis within the trpA gene of Escherichia coli
A Hardin, CF Villalta, M Doan, M Jabri, V Chockalingham, SJ White, ...
DNA repair 6 (2), 177-189, 2007
32007
The liquid biopsy Guardant360 CDx has robust performance at low inputs allowing for high rate of returning patient results
AO Richardson, A Hardin, S Shukla, J Zhao, C Barbacioru, H Beas, ...
Cancer Research 81 (13_Supplement), 572-572, 2021
22021
Abstract PS18-15: Real-world clinical-genomic data identifies the ESR1 clonal and subclonal circulating tumor DNA (ctDNA) landscape and provides insight into clinical outcomes
D Hanna, J Hutchins, J Yu, E Marino, N Kumar, R Kucharlapati, R Chavali, ...
Cancer Research 81 (4_Supplement), PS18-15-PS18-15, 2021
22021
Abstract PS18-28: Genomic heterogeneity and associated clinical outcomes of breast cancers treated with CDK4/6 inhibitors: Insights from real-world clinical genomic data
J Yu, C Ton, E Marino, N Kumar, R Kucharlapati, R Chavali, G Nayak, ...
Cancer Research 81 (4_Supplement), PS18-28-PS18-28, 2021
12021
PIK3CA mutational analysis using cell-free DNA next-generation sequencing detects activating mutations that may be missed with targeted hot-spot testing
LA Kiedrowski, D Juric, AI Hardin, KS Price, RJ Nagy, CL Arteaga, ...
CANCER RESEARCH 80 (4), 2020
12020
Determining a dynamic quality metric of a biopsy sample
S FAIRCLOUGH, AI HARDIN, D Hanna, CY Lee
US Patent App. 18/451,739, 2024
2024
Pan-Cancer Prevalence of Microsatellite Instability-High (MSI-H) Identified by Circulating Tumor DNA and Associated Real-World Clinical Outcomes
PM Kasi, LA Bucheit, J Liao, J Starr, P Barata, SJ Klempner, D Gandara, ...
JCO Precision Oncology 7, e2300118, 2023
2023
Analytical and clinical validation of a ctDNA assay for detecting copy number loss and structural rearrangement variants contributing to homologous recombination and repair …
J Yen, L Drusbosky, C Weipert, N Zhang, D Hanna, C Barbacioru, ...
CANCER RESEARCH 82 (4), 2022
2022
Abstract P5-13-29: Analytical and clinical validation of a ctDNA assay for detecting copy number loss and structural rearrangement variants contributing to homologous …
J Yen, L Drusbosky, C Weipert, N Zhang, D Hanna, C Barbacioru, ...
Cancer Research 82 (4_Supplement), P5-13-29-P5-13-29, 2022
2022
Significance modeling of clonal-level absence of target variants
A Artsiomenka, AI Hardin, S Fairclough, M Sikora, C Barbacioru
US Patent App. 17/162,897, 2021
2021
Genomic heterogeneity and associated clinical outcomes of breast cancers treated with CDK4/6 inhibitors: Insights from real-world clinical genomic data
J Yu, C Ton, E Marino, N Kumar, R Kucharlapati, R Chavali, G Nayak, ...
CANCER RESEARCH 81 (4), 2021
2021
Development of a clinical-genomic database to study tumor evolution and molecular biomarkers of drug resistance in a real-world setting
N Kumar, R Kucharlapati, A Hardin, VM Raymond, S Fairclough, K Lang
Cancer Research 80 (16_Supplement), 4421-4421, 2020
2020
Abstract P4-10-15: PIK3CA mutational analysis using cell-free DNA next-generation sequencing detects activating mutations that may be missed with targeted hot …
LA Kiedrowski, D Juric, AI Hardin, KS Price, RJ Nagy, CL Arteaga, ...
Cancer Research 80 (4_Supplement), P4-10-15-P4-10-15, 2020
2020
Detection of allele specific loss of heterozygosity in 70,000 patients with ctDNA
J Zhao, SR Fairclough, D Chudova, R Lanman, AA Talasaz, A Hardin
Cancer Research 79 (13_Supplement), 3769-3769, 2019
2019
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