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Steve Keir
Steve Keir
Professor of Neurosurgery, Duke University
Verified email at mc.duke.edu
Title
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Cited by
Year
An integrated genomic analysis of human glioblastoma multiforme
DW Parsons, S Jones, X Zhang, JCH Lin, RJ Leary, P Angenendt, ...
science 321 (5897), 1807-1812, 2008
68432008
The genetic landscape of the childhood cancer medulloblastoma
DW Parsons, M Li, X Zhang, S Jones, RJ Leary, JCH Lin, SM Boca, ...
science 331 (6016), 435-439, 2011
8092011
The integrated landscape of driver genomic alterations in glioblastoma
V Frattini, V Trifonov, JM Chan, A Castano, M Lia, F Abate, ST Keir, AX Ji, ...
Nature genetics 45 (10), 1141-1149, 2013
5882013
The pediatric preclinical testing program: description of models and early testing results
PJ Houghton, CL Morton, C Tucker, D Payne, E Favours, C Cole, ...
Pediatric blood & cancer 49 (7), 928-940, 2007
4992007
Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas
PJ Killela, CJ Pirozzi, P Healy, ZJ Reitman, E Lipp, BA Rasheed, R Yang, ...
Oncotarget 5 (6), 1515, 2014
2932014
Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001 …
RK Goudar, Q Shi, MD Hjelmeland, ST Keir, RE McLendon, CJ Wikstrand, ...
Molecular cancer therapeutics 4 (1), 101-112, 2005
2902005
Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)
JM Maris, CL Morton, R Gorlick, EA Kolb, R Lock, H Carol, ST Keir, ...
Pediatric blood & cancer 55 (1), 26-34, 2010
2632010
Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer
LW Jones, BL Viglianti, JA Tashjian, SM Kothadia, ST Keir, SJ Freedland, ...
Journal of applied physiology 108 (2), 343-348, 2010
2392010
Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF‐1 receptor by the pediatric preclinical testing program
EA Kolb, R Gorlick, PJ Houghton, CL Morton, R Lock, H Carol, ...
Pediatric blood & cancer 50 (6), 1190-1197, 2008
2122008
A novel low‐molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth
Q Shi, AB Hjelmeland, ST Keir, L Song, S Wickman, D Jackson, O Ohmori, ...
Molecular Carcinogenesis: Published in cooperation with the University of …, 2007
2102007
Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program
PJ Houghton, CL Morton, EA Kolb, R Gorlick, R Lock, H Carol, ...
Pediatric blood & cancer 50 (4), 799-805, 2008
2062008
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
SC Mack, KW Pajtler, L Chavez, K Okonechnikov, KC Bertrand, X Wang, ...
Nature 553 (7686), 101-105, 2018
1952018
Activity of temozolomide in the treatment of central nervous system tumor xenografts
HS Friedman, ME Dolan, AE Pegg, S Marcelli, S Keir, JJ Catino, ...
Cancer research 55 (13), 2853-2857, 1995
1791995
Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft
HS Friedman, SP Johnson, Q Dong, SC Schold, BKA Rasheed, ...
Cancer research 57 (14), 2933-2936, 1997
1771997
Poly (ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair–deficient malignant glioma xenograft
CL Cheng, SP Johnson, ST Keir, JA Quinn, F Ali-Osman, C Szabo, H Li, ...
Molecular cancer therapeutics 4 (9), 1364-1368, 2005
1672005
Initial testing (stage 1) of the BH3 mimetic ABT‐263 by the pediatric preclinical testing program
R Lock, H Carol, PJ Houghton, CL Morton, EA Kolb, R Gorlick, ...
Pediatric blood & cancer 50 (6), 1181-1189, 2008
1532008
KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation
C Guo, LH Chen, Y Huang, CC Chang, P Wang, CJ Pirozzi, X Qin, X Bao, ...
Oncotarget 4 (11), 2144, 2013
1512013
Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program
PJ Houghton, CL Morton, EA Kolb, R Lock, H Carol, CP Reynolds, ...
Pediatric blood & cancer 50 (1), 37-45, 2008
1452008
Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program
JM Maris, J Courtright, PJ Houghton, CL Morton, R Gorlick, EA Kolb, ...
Pediatric blood & cancer 50 (3), 581-587, 2008
1332008
Synergistic activity of PARP inhibition by talazoparib (BMN 673) with temozolomide in pediatric cancer models in the pediatric preclinical testing program
MA Smith, CP Reynolds, MH Kang, EA Kolb, R Gorlick, H Carol, RB Lock, ...
Clinical Cancer Research 21 (4), 819-832, 2015
1282015
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