Discovery and characterization of small molecules that target the GTPase Ral Nature 515 (7527), 443-447, 2014 | 154 | 2014 |
Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation H Xu, K Van der Jeught, Z Zhou, L Zhang, T Yu, Y Sun, Y Li, C Wan, ... The Journal of clinical investigation 131 (10), 2021 | 103 | 2021 |
Probing the reaction mechanism of spore photoproduct lyase (SPL) via diastereoselectively labeled dinucleotide SP TpT substrates L Yang, G Lin, D Liu, KJ Dria, J Telser, L Li Journal of the American Chemical Society 133 (27), 10434-10447, 2011 | 46 | 2011 |
Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases K Bum-Erdene, D Liu, G Gonzalez-Gutierrez, MK Ghozayel, D Xu, ... Proceedings of the National Academy of Sciences 117 (13), 7131-7139, 2020 | 31 | 2020 |
A new class of orthosteric uPAR· uPA small-molecule antagonists are allosteric inhibitors of the uPAR· vitronectin interaction D Liu, D Zhou, B Wang, WE Knabe, SO Meroueh ACS chemical biology 10 (6), 1521-1534, 2015 | 28 | 2015 |
Small-molecule CaVα1⋅ CaVβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking X Chen, D Liu, D Zhou, Y Si, D Xu, CW Stamatkin, MK Ghozayel, ... Proceedings of the National Academy of Sciences 115 (45), E10566-E10575, 2018 | 26 | 2018 |
Probing Binding and Cellular Activity of Pyrrolidinone and Piperidinone Small Molecules Targeting the Urokinase Receptor SOM Timmy Mani, Degang Liu, Donghui Zhou, Liwei Li, William Eric Knabe, Fang ... CHEMMEDCHEM 8 (12), 1963-1977, 2013 | 25 | 2013 |
Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer X Li, L Gera, S Zhang, Y Chen, L Lou, LM Wilson, ZR Xie, G Sautto, D Liu, ... Theranostics 11 (14), 6873, 2021 | 23 | 2021 |
Small molecules engage hot spots through cooperative binding to inhibit a tight protein–protein interaction D Liu, D Xu, M Liu, WE Knabe, C Yuan, D Zhou, M Huang, SO Meroueh Biochemistry 56 (12), 1768-1784, 2017 | 20 | 2017 |
Synthesis and biological evaluation of novel steroid-linked nitrogen mustards HB Zhang, JJ Xue, XL Zhao, DG Liu, Y Li Chinese Chemical Letters 20 (6), 680-683, 2009 | 17 | 2009 |
Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth D Zhou, MZ Springer, D Xu, D Liu, A Hudmon, KF Macleod, SO Meroueh Bioorganic & medicinal chemistry 25 (12), 2995-3005, 2017 | 10 | 2017 |
Formal total synthesis of benzylpedamide: The right half of (+)-pederin D Liu, J Xue, Z Xie, L Wei, X Zhang, Y Li Synlett 2008 (10), 1526-1528, 2008 | 10 | 2008 |
Structure‐based target‐specific screening leads to small‐molecule CaMKII inhibitors D Xu, L Li, D Zhou, D Liu, A Hudmon, SO Meroueh ChemMedChem 12 (9), 660-677, 2017 | 9 | 2017 |
Design and synthesis of fragment derivatives with a unique inhibition mechanism of the uPAR· uPA interaction K Bum-Erdene, D Liu, D Xu, MK Ghozayel, SO Meroueh ACS Medicinal Chemistry Letters 12 (1), 60-66, 2020 | 8 | 2020 |
Indications of 5′ to 3′ interbase electron transfer as the first step of pyrimidine dimer formation probed by a dinucleotide analog Y Jian, E Maximowitsch, D Liu, S Adhikari, L Li, T Domratcheva Chemistry–A European Journal 23 (31), 7526-7537, 2017 | 8 | 2017 |
Small molecules inhibit ex vivo tumor growth in bone D Zhou, K Bum-Erdene, D Xu, D Liu, D Tompkins, RS Sulaiman, ... Bioorganic & Medicinal Chemistry 26 (23-24), 6128-6134, 2018 | 3 | 2018 |
Asymmetric synthesis of pedamide using I2-induced heterocyclization to construct the skeleton DG Liu, JJ Xue, ZX Xie, LP Wei, HB Zhang, Y Li Chinese Chemical Letters 20 (7), 775-778, 2009 | 2 | 2009 |
Covalent Fragment Inhibits RhoA Activation by Guanine Exchange Factors MS Hussain, D Liu, WJ Alilain, SO Meroueh ACS Chemical Neuroscience 14 (14), 2509-2516, 2023 | 1 | 2023 |
Mimicking Native Interactions for Small-Molecule Inhibitors of Tight Protein-Protein Interactions D Xu, K Bum-Erdene, Y Si, D Zhou, D Liu, M Ghozayel, S Meroueh Journal of chemical information and modeling 57 (9), 2250, 2017 | | 2017 |
Structure-activity study of a new class of inhibitors of the uPAR-uPA protein-protein interaction that impair breast cancer cell invasion D Liu, T Mani, M Khanna, S Meroueh ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 246, 2013 | | 2013 |