Eukaryotic DNA topoisomerase IIβ CA Austin, KL Marsh Bioessays 20 (3), 215-226, 1998 | 346 | 1998 |
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia E Willmore, S de Caux, NJ Sunter, MJ Tilby, GH Jackson, CA Austin, ... Blood 103 (12), 4659-4665, 2004 | 331 | 2004 |
Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development G Capranico, S Tinelli, CA Austin, ML Fisher, F Zunino Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1132 (1 …, 1992 | 323 | 1992 |
γH2AX foci form preferentially in euchromatin after ionising-radiation IG Cowell, NJ Sunter, PB Singh, CA Austin, BW Durkacz, MJ Tilby PloS one 2 (10), e1057, 2007 | 281 | 2007 |
The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage TJ Wendorff, BH Schmidt, P Heslop, CA Austin, JM Berger Journal of molecular biology 424 (3-4), 109-124, 2012 | 257 | 2012 |
Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients M López-Lázaro, N Pastor, SS Azrak, MJ Ayuso, CA Austin, F Cortés Journal of natural products 68 (11), 1642-1645, 2005 | 242 | 2005 |
Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives CA Austin, S Patel, K Ono, H Nakane, LM Fisher Biochemical Journal 282 (3), 883-889, 1992 | 241 | 1992 |
Novel HeLa topoisomerase II is the IIβ isoform: complete coding sequence and homology with other type II topoisomerases CA Austin, JH Sng, S Patel, LM Fisher Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1172 (3 …, 1993 | 206 | 1993 |
Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity IG Cowell, Z Sondka, K Smith, KC Lee, CM Manville, ... Proceedings of the National Academy of Sciences 109 (23), 8989-8994, 2012 | 197 | 2012 |
Human topoisomerases and their roles in genome stability and organization Y Pommier, A Nussenzweig, S Takeda, C Austin Nature Reviews Molecular Cell Biology 23 (6), 407-427, 2022 | 185 | 2022 |
Etoposide targets topoisomerase IIα and IIβ in leukemic cells: Isoform-specific cleavable complexes visualized and quantifiedin situ by a novel immunofluorescence technique E Willmore, AJ Frank, K Padget, MJ Tilby, CA Austin Molecular pharmacology 54 (1), 78-85, 1998 | 177 | 1998 |
Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase IIα in yeast RA Wasserman, CA Austin, LM Fisher, JC Wang Cancer Research 53 (15), 3591-3596, 1993 | 172 | 1993 |
H2AX phosphorylation as a genotoxicity endpoint GP Watters, DJ Smart, JS Harvey, CA Austin Mutation Research/Genetic Toxicology and Environmental Mutagenesis 679 (1-2 …, 2009 | 170 | 2009 |
Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents IG Cowell, CA Austin International journal of environmental research and public health 9 (6 …, 2012 | 146 | 2012 |
NK314, a topoisomerase II inhibitor that specifically targets the α isoform E Toyoda, S Kagaya, IG Cowell, A Kurosawa, K Kamoshita, K Nishikawa, ... Journal of Biological Chemistry 283 (35), 23711-23720, 2008 | 145 | 2008 |
Expression, Domain Structure, and Enzymatic Properties of an Active Recombinant Human DNA Topoisomerase IIβ (∗) CA Austin, KL Marsh, RA Wasserman, E Willmore, PJ Sayer, JC Wang, ... Journal of Biological Chemistry 270 (26), 15739-15746, 1995 | 143 | 1995 |
The novel poly (ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks LM Smith, E Willmore, CA Austin, NJ Curtin Clinical cancer research 11 (23), 8449-8457, 2005 | 135 | 2005 |
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia E Willmore, SL Elliott, T Mainou-Fowler, GP Summerfield, GH Jackson, ... Clinical cancer research 14 (12), 3984-3992, 2008 | 134 | 2008 |
Murine transgenic cells lacking DNA topoisomerase IIβ are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation F Errington, E Willmore, MJ Tilby, L Li, G Li, W Li, BC Baguley, CA Austin Molecular pharmacology 56 (6), 1309-1316, 1999 | 133 | 1999 |
The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells M López-Lázaro, E Willmore, CA Austin Mutation Research/Genetic Toxicology and Environmental Mutagenesis 696 (1 …, 2010 | 128 | 2010 |