| Ontogeny of early life immunity DJ Dowling, O Levy Trends in immunology 35 (7), 299-310, 2014 | 388 | 2014 |
| Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses DJ Dowling, CM Hamilton, S Donnelly, J La Course, PM Brophy, J Dalton, ... Infection and immunity 78 (2), 793-801, 2010 | 182 | 2010 |
| The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function CM Hamilton, DJ Dowling, CE Loscher, RM Morphew, PM Brophy, ... Infection and immunity 77 (6), 2488-2498, 2009 | 162 | 2009 |
| Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses DJ Dowling, EA Scott, A Scheid, I Bergelson, S Joshi, C Pietrasanta, ... Journal of Allergy and Clinical Immunology 140 (5), 1339-1350, 2017 | 154 | 2017 |
| Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways VJ Philbin, DJ Dowling, LC Gallington, G Cortés, Z Tan, EE Suter, KW Chi, ... Journal of Allergy and Clinical Immunology 130 (1), 195-204. e9, 2012 | 128 | 2012 |
| Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants DJ Dowling ImmunoHorizons 2 (6), 185-197, 2018 | 127 | 2018 |
| Toward precision adjuvants: optimizing science and safety E Nanishi, DJ Dowling, O Levy Current opinion in pediatrics 32 (1), 125-138, 2020 | 107 | 2020 |
| A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands D Dowling, CM Hamilton, SM O’Neill Cytokine 41 (3), 254-262, 2008 | 101 | 2008 |
| TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth DJ Dowling, SD van Haren, A Scheid, I Bergelson, D Kim, CJ Mancuso, ... JCI insight 2 (6), 2017 | 94 | 2017 |
| Age-specific adjuvant synergy: dual TLR7/8 and Mincle activation of human newborn dendritic cells enables Th1 polarization SD van Haren, DJ Dowling, W Foppen, D Christensen, P Andersen, ... The Journal of Immunology 197 (11), 4413-4424, 2016 | 94 | 2016 |
| The Sigma Class Glutathione Transferase from the Liver Fluke Fasciola hepatica EJ LaCourse, S Perally, RM Morphew, JV Moxon, M Prescott, DJ Dowling, ... PLoS neglected tropical diseases 6 (5), e1666, 2012 | 85 | 2012 |
| An aluminum hydroxide: CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice E Nanishi, F Borriello, TR O’Meara, ME McGrath, Y Saito, RE Haupt, ... Science Translational Medicine 14 (629), eabj5305, 2021 | 81* | 2021 |
| The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes DJ Dowling, Z Tan, ZM Prokopowicz, CD Palmer, MAH Matthews, ... PloS one 8 (3), e58164, 2013 | 75 | 2013 |
| BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny A Angelidou, J Diray-Arce, MG Conti, KK Smolen, SD Van Haren, ... Frontiers in Microbiology 11, 332, 2020 | 68 | 2020 |
| Identification and characterization of stimulator of interferon genes as a robust adjuvant target for early life immunization F Borriello, C Pietrasanta, JCY Lai, LM Walsh, P Sharma, DN O’Driscoll, ... Frontiers in immunology 8, 1772, 2017 | 56 | 2017 |
| The imidazoquinoline toll-like receptor-7/8 agonist hybrid-2 potently induces cytokine production by human newborn and adult leukocytes L Ganapathi, S Van Haren, DJ Dowling, I Bergelson, NM Shukla, ... PLoS One 10 (8), e0134640, 2015 | 56 | 2015 |
| In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant SD van Haren, L Ganapathi, I Bergelson, DJ Dowling, M Banks, ... Cytokine 83, 99-109, 2016 | 53 | 2016 |
| Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns EM Speer, DJ Dowling, LS Ozog, J Xu, J Yang, G Kennady, O Levy Pediatric research 81 (5), 806-816, 2017 | 47 | 2017 |
| An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity F Borriello, V Poli, E Shrock, R Spreafico, X Liu, N Pishesha, C Carpenet, ... Cell 185 (4), 614-629. e21, 2022 | 46 | 2022 |
| Pediatric vaccine adjuvants: Components of the modern vaccinologist's toolbox DJ Dowling, O Levy The Pediatric infectious disease journal 34 (12), 1395, 2015 | 46 | 2015 |
Ofer LevyDirector, Precision Vaccines Program & Principal Investigator, Boston Children's HospitalVerified email at childrens.harvard.edu
