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Vito Genna
Vito Genna
Nostum Biodiscovery
Verified email at irbbarcelona.org - Homepage
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Cited by
Year
Metal–ligand interactions in drug design
L Riccardi, V Genna, M De Vivo
Nature Reviews Chemistry 2 (7), 100-112, 2018
1532018
A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids
S Arangundy-Franklin, AI Taylor, BT Porebski, V Genna, S Peak-Chew, ...
Nature chemistry 11 (6), 533-542, 2019
772019
A Self-activated Mechanism for Nucleic acid Polymerization Catalyzed by DNA/RNA Polymerases
V Genna, P Vidossich, E Ippoliti, P Carloni, M De Vivo
J. Am. Chem. Soc 138 (44), 14592-14598, 2016
692016
Cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase-η
V Genna, R Gaspari, M Dal Peraro, M De Vivo
Nucleic acids research 44 (6), 2827-2836, 2016
472016
Author Correction: Visualizing group II intron dynamics between the first and second steps of splicing
J Manigrasso, I Chillón, V Genna, P Vidossich, S Somarowthu, AM Pyle, ...
Nature Communications 13 (1), 1, 2022
342022
Second-shell basic residues expand the two-metal-ion architecture of DNA and RNA processing enzymes
V Genna, M Colombo, M De Vivo, M Marcia
Structure 26 (1), 40-50. e2, 2018
342018
Visualizing group II intron dynamics between the first and second steps of splicing
J Manigrasso, I Chillón, V Genna, P Vidossich, S Somarowthu, AM Pyle, ...
Nature communications 11 (1), 2837, 2020
332020
The catalytic mechanism of DNA and RNA polymerases
V Genna, E Donati, M De Vivo
ACS Catalysis 8 (12), 11103-11118, 2018
292018
Simulating enzyme reactivity: computational methods in enzyme catalysis
I Tuñón, V Moliner
Royal Society of Chemistry, 2016
292016
Antigenic Peptide Molecular Recognition by the DRB1–DQB1 Haplotype Modulates Multiple Sclerosis Susceptibility
A Kumar, P Melis, V Genna, E Cocco, MG Marrosu, E Pieroni
Molecular BioSystems 10 (8), 2043-2054, 2014
282014
A strategically located Arg/Lys residue promotes correct base paring during nucleic acid biosynthesis in polymerases
V Genna, P Carloni, M De Vivo
Journal of the American Chemical Society 140 (9), 3312-3321, 2018
252018
A transient and flexible cation− π interaction promotes hydrolysis of nucleic acids in DNA and RNA nucleases
V Genna, M Marcia, M De Vivo
Journal of the American Chemical Society 141 (27), 10770-10776, 2019
242019
Recruiting mechanism and functional role of a third metal ion in the enzymatic activity of 5′ structure-specific nucleases
E Donati, V Genna, M De Vivo
Journal of the American Chemical Society 142 (6), 2823-2834, 2020
202020
Novel, potent, and druglike tetrahydroquinazoline inhibitor that is highly selective for human topoisomerase II α over β
JA Ortega, JM Arencibia, E Minniti, JAW Byl, S Franco-Ulloa, M Borgogno, ...
Journal of medicinal chemistry 63 (21), 12873-12886, 2020
172020
Chemoselective synthesis of N-terminal cysteinyl thioesters via β, γ-C, S thiol-michael addition
R Petracca, KA Bowen, L McSweeney, S O’Flaherty, V Genna, B Twamley, ...
Organic letters 21 (9), 3281-3285, 2019
172019
The origins and the biological consequences of the Pur/Pyr DNA· RNA asymmetry
M Terrazas, V Genna, G Portella, N Villegas, D Sanchez, C Arnan, ...
Chem 5 (6), 1619-1631, 2019
122019
Pre-Exascale HPC-approaches for Molecular Dynamics simulations. Covid-19 research: a use case.
MO Milosz Wieczor, Vito Gena, Juan Aranda, Rosa M. Badia, Josep Lluis Gelpi ...
WIREs Computational Molecular Science, In Press, 2022
6*2022
Encoded synthesis and evolution of alkyl-phosphonate nucleic acids: A synthetic genetic polymer with an uncharged backbone chemistry
S Arangundy-Franklin, AI Taylor, BT Porebski, V Genna, S Peak-Chew, ...
Nature chemistry 11 (6), 533, 2019
32019
First Principles Methods in Biology: From Continuum Models to Hybrid Ab initio Quantum Mechanics/Molecular Mechanics
J Dreyer, G Brancato, E Ippoliti, V Genna, M De Vivo, P Carloni, ...
32016
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
V Genna, J Iglesias-Fernández, L Reyes-Fraile, N Villegas, K Guckian, ...
Nucleic acids research 51 (10), 4713-4725, 2023
22023
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