| Structure and mechanism of an amino acid antiporter X Gao, F Lu, L Zhou, S Dang, L Sun, X Li, J Wang, Y Shi Science 324 (5934), 1565-1568, 2009 | 248 | 2009 |
| Structure of a presenilin family intramembrane aspartate protease X Li, S Dang, C Yan, X Gong, J Wang, Y Shi Nature 493 (7430), 56-61, 2013 | 230 | 2013 |
| Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2 X Li, P Saha, J Li, G Blobel, SR Pfeffer Proceedings of the National Academy of Sciences 113 (36), 10079-10084, 2016 | 179 | 2016 |
| Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies SM Condon, Y Mitsuuchi, Y Deng, MG LaPorte, SR Rippin, T Haimowitz, ... Journal of medicinal chemistry 57 (9), 3666-3677, 2014 | 174 | 2014 |
| Structures of human Patched and its complex with native palmitoylated sonic hedgehog X Qi, P Schmiege, E Coutavas, J Wang, X Li Nature 560 (7716), 128-132, 2018 | 170 | 2018 |
| Structure of human Niemann–Pick C1 protein X Li, J Wang, E Coutavas, H Shi, Q Hao, G Blobel Proceedings of the National Academy of Sciences 113 (29), 8212-8217, 2016 | 170 | 2016 |
| Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi X Qi, H Liu, B Thompson, J McDonald, C Zhang, X Li Nature 571 (7764), 279-283, 2019 | 147 | 2019 |
| Human TRPML1 channel structures in open and closed conformations P Schmiege, M Fine, G Blobel, X Li Nature 550 (7676), 366-370, 2017 | 136 | 2017 |
| Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex X Qi, P Schmiege, E Coutavas, X Li Science 362 (6410), eaas8843, 2018 | 121 | 2018 |
| 3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport X Li, F Lu, MN Trinh, P Schmiege, J Seemann, J Wang, G Blobel Proceedings of the National Academy of Sciences 114 (34), 9116-9121, 2017 | 100 | 2017 |
| Molecular basis of V-ATPase inhibition by bafilomycin A1 R Wang, J Wang, A Hassan, CH Lee, XS Xie, X Li Nature communications 12 (1), 1782, 2021 | 94 | 2021 |
| Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage X Li, B Wang, L Feng, H Kang, Y Qi, J Wang, Y Shi Proceedings of the National Academy of Sciences 106 (35), 14837-14842, 2009 | 79 | 2009 |
| Structural basis for PtdInsP2-mediated human TRPML1 regulation M Fine, P Schmiege, X Li Nature Communications 9 (1), 4192, 2018 | 72 | 2018 |
| Mechanistic insights into the generation and transduction of hedgehog signaling X Qi, X Li Trends in biochemical sciences 45 (5), 397-410, 2020 | 69 | 2020 |
| Structural basis for itraconazole-mediated NPC1 inhibition T Long, X Qi, A Hassan, Q Liang, JK De Brabander, X Li Nature communications 11 (1), 152, 2020 | 66 | 2020 |
| Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling X Qi, L Friedberg, R De Bose-Boyd, T Long, X Li Nature chemical biology 16 (12), 1368-1375, 2020 | 65 | 2020 |
| Triazoles inhibit cholesterol export from lysosomes by binding to NPC1 MN Trinh, F Lu, X Li, A Das, Q Liang, JK De Brabander, MS Brown, ... Proceedings of the National Academy of Sciences 114 (1), 89-94, 2017 | 65 | 2017 |
| Structure of nevanimibe-bound tetrameric human ACAT1 T Long, Y Sun, A Hassan, X Qi, X Li Nature 581 (7808), 339-343, 2020 | 62 | 2020 |
| Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum X Li, R Roberti, G Blobel Nature 517 (7532), 104-107, 2015 | 59 | 2015 |
| Cryo-EM structures of intact V-ATPase from bovine brain R Wang, T Long, A Hassan, J Wang, Y Sun, XS Xie, X Li Nature communications 11 (1), 3921, 2020 | 57 | 2020 |
Xiaofeng QiAssistant Professor, UT Southwestern Medical CenterVerified email at utsouthwestern.edu
