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Michelle Rich
Michelle Rich
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Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility
EM Williams, RF Little, AM Mowday, MH Rich, JVE Chan-Hyams, ...
Biochemical Journal 471 (2), 131-153, 2015
1412015
Toward a high-throughput screening platform for directed evolution of enzymes that activate genotoxic prodrugs
JN Copp, EM Williams, MH Rich, AV Patterson, JB Smaill, DF Ackerley
Protein Engineering, Design & Selection 27 (10), 399-403, 2014
322014
Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections
JN Copp, D Pletzer, AS Brown, JV der Heijden, CM Miton, RJ Edgar, ...
mBio 11 (5), e02068-20, 2020
292020
Mechanism of two-/four-electron reduction of nitroaromatics by oxygen-insensitive nitroreductases: the role of a non-enzymatic reduction step
B Valiauga, L Misevičienė, MH Rich, DF Ackerley, J Šarlauskas, N Čėnas
Molecules 23 (7), 1672, 2018
172018
Engineering Escherichia coli NfsB to activate a hypoxia-resistant analogue of the PET probe EF5 to enable non-invasive imaging during enzyme prodrug therapy
EM Williams, MH Rich, AM Mowday, A Ashoorzadeh, JN Copp, CP Guise, ...
Biochemistry 58 (35), 3700-3710, 2019
122019
Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and …
MH Rich, AV Sharrock, KR Hall, DF Ackerley, JK MacKichan
Biotechnology letters 40, 359-367, 2018
112018
Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System
AV Sharrock, SP McManaway, MH Rich, JS Mumm, IF Hermans, M Tercel, ...
Frontiers in Pharmacology 12, 701456, 2021
82021
Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues
KR Hall, KJ Robins, EM Williams, MH Rich, MJ Calcott, JN Copp, RF Little, ...
Elife 9, e59081, 2020
7*2020
Discovery and directed evolution of nitroreductase enzymes for activation of prodrugs and PET imaging compounds
MH Rich
Victoria University of Wellington, 2017
32017
Non-canonical (unusual) amino acids as a toolbox for antimicrobial and anticancer peptide synthesis
MH Rich, KE O'Connor, T Narancic
Amino Acids, Peptides and Proteins, 44-63, 2020
22020
Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug
MH Rich, AV Sharrock, A Ashoorzadeh, AV Patterson, JB Smaill, ...
Biotechnology Letters 43 (1), 203-211, 2021
12021
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening
MH Rich, AV Sharrock, TS Mulligan, F Matthews, AS Brown, ...
Cell Chemical Biology, 2023
2023
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