Physiologically based pharmacokinetic modeling and simulation in pediatric drug development AR Maharaj, AN Edginton CPT: pharmacometrics & systems pharmacology 3 (11), 1-13, 2014 | 181 | 2014 |
A workflow example of PBPK modeling to support pediatric research and development: case study with lorazepam AR Maharaj, JS Barrett, AN Edginton The AAPS journal 15, 455-464, 2013 | 122 | 2013 |
Assessment of age-related changes in pediatric gastrointestinal solubility AR Maharaj, AN Edginton, N Fotaki Pharmaceutical research 33, 52-71, 2016 | 59 | 2016 |
Examining small intestinal transit time as a function of age: is there evidence to support age-dependent differences among children? AR Maharaj, AN Edginton Drug Metabolism and Disposition 44 (7), 1080-1089, 2016 | 46 | 2016 |
Simulated assessment of pharmacokinetically guided dosing for investigational treatments of pediatric patients with coronavirus disease 2019 AR Maharaj, H Wu, CP Hornik, SJ Balevic, CD Hornik, PB Smith, ... JAMA pediatrics 174 (10), e202422-e202422, 2020 | 42 | 2020 |
Improving pediatric protein binding estimates: an evaluation of α1-acid glycoprotein maturation in healthy and infected subjects AR Maharaj, D Gonzalez, M Cohen-Wolkowiez, CP Hornik, AN Edginton Clinical pharmacokinetics 57, 577-589, 2018 | 29 | 2018 |
Hydroxychloroquine in patients with rheumatic disease complicated by COVID-19: clarifying target exposures and the need for clinical trials SJ Balevic, CP Hornik, TP Green, MEB Clowse, D Gonzalez, AR Maharaj, ... The Journal of rheumatology 47 (9), 1424-1430, 2020 | 24 | 2020 |
CNS penetration and pharmacodynamics of the CHK1 inhibitor prexasertib in a mouse Group 3 medulloblastoma model O Campagne, A Davis, AR Maharaj, B Zhong, J Stripay, D Farmer, ... European Journal of Pharmaceutical Sciences 142, 105106, 2020 | 16 | 2020 |
Hydroxychloroquine PK and exposure-response in pregnancies with lupus: the importance of adherence for neonatal outcomes SJ Balevic, D Weiner, MEB Clowse, AM Eudy, AR Maharaj, CP Hornik, ... Lupus Science & Medicine 9 (1), e000602, 2022 | 15 | 2022 |
Physiologically based pharmacokinetic modeling for trimethoprim and sulfamethoxazole in children EJ Thompson, H Wu, A Maharaj, AN Edginton, SJ Balevic, M Cobbaert, ... Clinical pharmacokinetics 58, 887-898, 2019 | 13 | 2019 |
Effect of an ethanol/trisodium citrate hemodialysis catheter locking solution on isolates of Candida albicans AR Maharaj, SA Zelenitsky, LM Vercaigne Hemodialysis International 12 (3), 342-347, 2008 | 12 | 2008 |
A randomized, controlled pharmacokinetic and pharmacodynamics trial of ambrisentan after Fontan surgery KD Hill, AR Maharaj, JS Li, E Thompson, PCA Barker, CP Hornik Pediatric Critical Care Medicine 21 (9), e795-e803, 2020 | 10 | 2020 |
Dosing of continuous fentanyl infusions in obese children: a population pharmacokinetic analysis AR Maharaj, H Wu, KO Zimmerman, DG Speicher, JE Sullivan, K Watt, ... The Journal of Clinical Pharmacology 60 (5), 636-647, 2020 | 10 | 2020 |
A pharmacoepidemiologic study of the safety and effectiveness of clindamycin in infants RG Greenberg, H Wu, A Maharaj, M Cohen-Wolkowiez, KM Tomashek, ... The Pediatric infectious disease journal 39 (3), 204-210, 2020 | 10 | 2020 |
Population pharmacokinetics of olanzapine in children AR Maharaj, H Wu, KO Zimmerman, J Autmizguine, R Kalra, A Al‐Uzri, ... British journal of clinical pharmacology 87 (2), 542-554, 2021 | 9 | 2021 |
Use of normalized prediction distribution errors for assessing population physiologically-based pharmacokinetic model adequacy AR Maharaj, H Wu, CP Hornik, A Arrieta, L James, V Bhatt-Mehta, ... Journal of pharmacokinetics and pharmacodynamics 47, 199-218, 2020 | 8 | 2020 |
Parameterization of small intestinal water volume using PBPK modeling A Maharaj, N Fotaki, A Edginton European Journal of Pharmaceutical Sciences 67, 55-64, 2015 | 8 | 2015 |
Pharmacokinetics of ceftazidime in children and adolescents with obesity AR Maharaj, H Wu, KO Zimmerman, WJ Muller, JE Sullivan, CMT Sherwin, ... Pediatric Drugs 23, 499-513, 2021 | 7 | 2021 |
Pitfalls of using numerical predictive checks for population physiologically-based pharmacokinetic model evaluation AR Maharaj, H Wu, CP Hornik, M Cohen-Wolkowiez Journal of pharmacokinetics and pharmacodynamics 46, 263-272, 2019 | 7 | 2019 |
Development and validation of a sensitive LC MS/MS method for the measurement of the checkpoint kinase 1 inhibitor prexasertib and its application in a cerebral microdialysis study B Zhong, A Maharaj, A Davis, MF Roussel, CF Stewart Journal of pharmaceutical and biomedical analysis 156, 97-103, 2018 | 7 | 2018 |