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Manar Shafat
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Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment
MS Shafat, T Oellerich, S Mohr, SD Robinson, DR Edwards, CR Marlein, ...
Blood, The Journal of the American Society of Hematology 129 (10), 1320-1332, 2017
2892017
NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts
CR Marlein, L Zaitseva, RE Piddock, SD Robinson, DR Edwards, ...
Blood, The Journal of the American Society of Hematology 130 (14), 1649-1660, 2017
2872017
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer
F Brasó-Maristany, S Filosto, S Catchpole, R Marlow, J Quist, ...
Nature medicine 22 (11), 1303-1313, 2016
2212016
The bone marrow microenvironment–Home of the leukemic blasts
MS Shafat, B Gnaneswaran, KM Bowles, SA Rushworth
Blood reviews 31 (5), 277-286, 2017
1452017
MIF-induced stromal PKCβ/IL8 is essential in human acute myeloid leukemia
AM Abdul-Aziz, MS Shafat, TK Mehta, F Di Palma, MJ Lawes, ...
Cancer research 77 (2), 303-311, 2017
852017
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment
AM Abdul-Aziz, Y Sun, C Hellmich, CR Marlein, J Mistry, E Forde, ...
Blood, The Journal of the American Society of Hematology 133 (5), 446-456, 2019
802019
Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML
L Zaitseva, MY Murray, MS Shafat, MJ Lawes, DJ MacEwan, KM Bowles, ...
Oncotarget 5 (20), 9930, 2014
782014
Inflammatory differences in plaque erosion and rupture in patients with ST‐segment elevation myocardial infarction
S Chandran, J Watkins, A Abdul‐Aziz, M Shafat, PA Calvert, KM Bowles, ...
Journal of the American Heart Association 6 (5), e005868, 2017
502017
Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection
G Pillinger, NV Loughran, RE Piddock, MS Shafat, L Zaitseva, ...
Oncotarget 7 (26), 39784, 2016
362016
HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia
AM Abdul-Aziz, MS Shafat, Y Sun, CR Marlein, RE Piddock, SD Robinson, ...
Oncogene 37 (20), 2676-2686, 2018
282018
Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC
RE Piddock, CR Marlein, A Abdul-Aziz, MS Shafat, MJ Auger, KM Bowles, ...
Journal of hematology & oncology 11, 1-4, 2018
222018
Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells
SA Rushworth, G Pillinger, A Abdul-Aziz, R Piddock, MS Shafat, ...
The Lancet Haematology 2 (5), e204-e211, 2015
202015
Cellular therapeutic approaches to cytomegalovirus infection following allogeneic stem cell transplantation
MS Shafat, V Mehra, KS Peggs, C Roddie
Frontiers in Immunology 11, 550178, 2020
182020
Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer
F Braso-Maristany, S Filosto, S Catchpole, R Marlow, J Quist, ...
Nature medicine 23 (4), 526, 2017
82017
Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference?
M Shafat, K Rajakumar, H Syme, N Buchholz, MM Knight
Urolithiasis 41, 481-486, 2013
82013
PGC1α driven mitochondrial biogenesis within the bone marrow stromal cells of the acute myeloid leukemia micro-environment is a pre-requisite for mitochondrial transfer to …
C Marlein, L Zaitseva, R Piddock, M Shafat, A Collins, K Bowles, ...
Blood 130, 3927, 2017
62017
Pembrolizumab for the treatment of progressive multifocal leukoencephalopathy following anti‐CD19 CAR‐T therapy: a case report
S Mackenzie, M Shafat, H Roddy, H Hyare, L Neill, MAV Marzolini, ...
EJHaem 2 (4), 848-853, 2021
52021
Dual activation of NRF2 in multiple myeloma and bone marrow mesenchymal stromal cells regulates chemotherapy resistance
Y Sun, L Zaitseva, MS Shafat, KM Bowles, SA Rushworth
Blood, The Journal of the American Society of Hematology 128 (22), 3287-3287, 2016
52016
Multi-organ graft-versus-host disease after nivolumab for relapsed Hodgkin lymphoma: the role of plasma exchange
R Amerikanou, L Neill, M Shafat, H Roddy, H Hyare, S Hughes, ...
The Lancet Haematology 8 (11), e862, 2021
42021
Synthesis of Carboxamide‐Containing Tranylcypromine Analogues as LSD1 (KDM1A) Inhibitors Targeting Acute Myeloid Leukemia
M Teresa Borrello, H Benelkebir, A Lee, C Hin Tam, M Shafat, ...
ChemMedChem 16 (8), 1316-1324, 2021
42021
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