| Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus CC Wen, YH Kuo, JT Jan, PH Liang, SY Wang, HG Liu, CK Lee, ... Journal of medicinal chemistry 50 (17), 4087-4095, 2007 | 649 | 2007 |
| Small molecules targeting severe acute respiratory syndrome human coronavirus CY Wu, JT Jan, SH Ma, CJ Kuo, HF Juan, YSE Cheng, HH Hsu, ... Proceedings of the National Academy of Sciences 101 (27), 10012-10017, 2004 | 632 | 2004 |
| Structure, mechanism and function of prenyltransferases PH Liang, TP Ko, AHJ Wang European Journal of Biochemistry 269 (14), 3339-3354, 2002 | 553 | 2002 |
| Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality D Lee, SA Long, JL Adams, G Chan, KS Vaidya, TA Francis, K Kikly, ... Journal of Biological Chemistry 275 (21), 16007-16014, 2000 | 318 | 2000 |
| Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3, 3'-digallate (TF3) CN Chen, CPC Lin, KK Huang, WC Chen, HP Hsieh, PH Liang, JTA Hsu Evidence-Based Complementary and Alternative Medicine 2, 209-215, 2005 | 313 | 2005 |
| Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl: adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA … PC Babbitt, GL Kenyon, BM Martin, H Charest, M Slyvestre, JD Scholten, ... Biochemistry 31 (24), 5594-5604, 1992 | 272 | 1992 |
| Mechanism of the maturation process of SARS-CoV 3CL protease*[boxs] MF Hsu, CJ Kuo, KT Chang, HC Chang, CC Chou, TP Ko, HL Shr, ... Journal of Biological Chemistry 280 (35), 31257-31266, 2005 | 262 | 2005 |
| Bisphosphonates target multiple sites in both cis-and trans-prenyltransferases RT Guo, R Cao, PH Liang, TP Ko, TH Chang, MP Hudock, WY Jeng, ... Proceedings of the National Academy of Sciences 104 (24), 10022-10027, 2007 | 220 | 2007 |
| Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis WY Jeng, NC Wang, MH Lin, CT Lin, YC Liaw, WJ Chang, CI Liu, ... Journal of structural biology 173 (1), 46-56, 2011 | 218 | 2011 |
| Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication CC Wen, LF Shyur, JT Jan, PH Liang, CJ Kuo, P Arulselvan, JB Wu, ... Journal of traditional and complementary medicine 1 (1), 41-50, 2011 | 186 | 2011 |
| Loop Closure and Intersubunit Communication in Tryptophan Synthase, TR Schneider, E Gerhardt, M Lee, PH Liang, KS Anderson, I Schlichting Biochemistry 37 (16), 5394-5406, 1998 | 182 | 1998 |
| Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease IL Lu, N Mahindroo, PH Liang, YH Peng, CJ Kuo, KC Tsai, HP Hsieh, ... Journal of medicinal chemistry 49 (17), 5154-5161, 2006 | 181 | 2006 |
| Raman difference spectroscopic studies of dithiobenzoyl substrate and product analogs binding to the enzyme dehalogenase: π‐electron polarization is prevented by the C O to C … J Dong, L Luo, PH Liang, D Dunaway‐Mariano, PR Carey Journal of Raman Spectroscopy 31 (5), 365-371, 2000 | 175 | 2000 |
| Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate CJ Kuo, YH Chi, JTA Hsu, PH Liang Biochemical and biophysical research communications 318 (4), 862-867, 2004 | 169 | 2004 |
| Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds CC Lee, CJ Kuo, TP Ko, MF Hsu, YC Tsui, SC Chang, S Yang, SJ Chen, ... Journal of Biological Chemistry 284 (12), 7646-7655, 2009 | 156 | 2009 |
| Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease CY Wu, KY King, CJ Kuo, JM Fang, YT Wu, MY Ho, CL Liao, JJ Shie, ... Chemistry & biology 13 (3), 261-268, 2006 | 156 | 2006 |
| Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and … RT Guo, TP Ko, APC Chen, CJ Kuo, AHJ Wang, PH Liang Journal of Biological Chemistry 280 (21), 20762-20774, 2005 | 145 | 2005 |
| Anti-SARS coronavirus agents: a patent review (2008–present) V Kumar, YS Jung, PH Liang Expert opinion on therapeutic patents 23 (10), 1337-1348, 2013 | 138 | 2013 |
| Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α, β-unsaturated esters JJ Shie, JM Fang, TH Kuo, CJ Kuo, PH Liang, HJ Huang, YT Wu, JT Jan, ... Bioorganic & medicinal chemistry 13 (17), 5240-5252, 2005 | 129 | 2005 |
| Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint (Mentha piperita) Reveals Intersubunit Regulation TH Chang, FL Hsieh, TP Ko, KH Teng, PH Liang, AHJ Wang The Plant Cell 22 (2), 454-467, 2010 | 122 | 2010 |
