| The ambiguous base-pairing and high substrate efficiency of T-705 (favipiravir) ribofuranosyl 5′-triphosphate towards influenza A virus polymerase Z Jin, LK Smith, VK Rajwanshi, B Kim, J Deval PloS one 8 (7), e68347, 2013 | 291 | 2013 |
| Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human … G Wang, J Deval, J Hong, N Dyatkina, M Prhavc, J Taylor, A Fung, Z Jin, ... Journal of medicinal chemistry 58 (4), 1862-1878, 2015 | 151 | 2015 |
| Structure of the respiratory syncytial virus polymerase complex MSA Gilman, C Liu, A Fung, I Behera, P Jordan, P Rigaux, N Ysebaert, ... Cell 179 (1), 193-204. e14, 2019 | 137 | 2019 |
| Efficiency of incorporation and chain termination determines the inhibition potency of 2′-modified nucleotide analogs against hepatitis C virus polymerase A Fung, Z Jin, N Dyatkina, G Wang, L Beigelman, J Deval Antimicrobial agents and chemotherapy 58 (7), 3636-3645, 2014 | 96 | 2014 |
| Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues G Wang, J Wan, Y Hu, X Wu, M Prhavc, N Dyatkina, VK Rajwanshi, ... Journal of medicinal chemistry 59 (10), 4611-4624, 2016 | 91 | 2016 |
| Molecular basis for the selective inhibition of respiratory syncytial virus RNA polymerase by 2'-fluoro-4'-chloromethyl-cytidine triphosphate J Deval, J Hong, G Wang, J Taylor, LK Smith, A Fung, SK Stevens, H Liu, ... PLoS pathogens 11 (6), e1004995, 2015 | 83 | 2015 |
| Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2′-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases Z Jin, K Tucker, X Lin, CC Kao, K Shaw, H Tan, J Symons, I Behera, ... Antimicrobial agents and chemotherapy 59 (12), 7504-7516, 2015 | 79 | 2015 |
| Substituted nucleosides, nucleotides and analogs thereof L Beigelman, J Deval, Z Jin US Patent 9,815,864, 2017 | 72 | 2017 |
| Structure (s), function (s), and inhibition of the RNA-dependent RNA polymerase of noroviruses J Deval, Z Jin, YC Chuang, CC Kao Virus research 234, 21-33, 2017 | 71 | 2017 |
| Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex Z Jin, V Leveque, H Ma, KA Johnson, K Klumpp Journal of Biological Chemistry 287 (13), 10674-10683, 2012 | 65 | 2012 |
| Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity Z Jin, J Deval, KA Johnson, DC Swinney Journal of biological chemistry 286 (3), 2067-2077, 2011 | 52 | 2011 |
| Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs Z Jin, A Kinkade, I Behera, S Chaudhuri, K Tucker, N Dyatkina, ... Antiviral research 143, 151-161, 2017 | 45 | 2017 |
| Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′-C-methyluridine 5 … G Wang, N Dyatkina, M Prhavc, C Williams, V Serebryany, Y Hu, Y Huang, ... Journal of medicinal chemistry 62 (9), 4555-4570, 2019 | 40 | 2019 |
| NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase Z Jin, V Leveque, H Ma, KA Johnson, K Klumpp Proceedings of the National Academy of Sciences 110 (5), E348-E357, 2013 | 38 | 2013 |
| Site-specific labeling of T7 DNA polymerase with a conformationally sensitive fluorophore and its use in detecting single-nucleotide polymorphisms YC Tsai, Z Jin, KA Johnson Analytical biochemistry 384 (1), 136-144, 2009 | 28 | 2009 |
| Subgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases X Lin, L Thorne, Z Jin, LA Hammad, S Li, J Deval, IG Goodfellow, CC Kao Nucleic acids research 43 (1), 446-460, 2015 | 25 | 2015 |
| Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic … G Wang, N Dyatkina, M Prhavc, C Williams, V Serebryany, Y Hu, Y Huang, ... Journal of Medicinal Chemistry 63 (18), 10380-10395, 2020 | 22 | 2020 |
| Substituted nucleosides, nucleotides and analogs thereof L Beigelman, J Deval, Z Jin US Patent App. 15/795,983, 2018 | 17 | 2018 |
| Role of a GAG hinge in the nucleotide-induced conformational change governing nucleotide specificity by T7 DNA polymerase Z Jin, KA Johnson Journal of biological chemistry 286 (2), 1312-1322, 2011 | 12 | 2011 |
| Pre-Steady-State Kinetic Analysis of cis-3-Chloroacrylic Acid Dehalogenase: Analysis and Implications BA Robertson, GK Schroeder, Z Jin, KA Johnson, CP Whitman Biochemistry 48 (49), 11737-11744, 2009 | 12 | 2009 |
Kenneth A JohnsonProfesor of Biochemistry, University of Texas, Penn State University, University of ChicagoVerified email at mail.utexas.edu
