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Xianming Deng
Xianming Deng
Verified email at xmu.edu.cn
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Cited by
Year
Systematic identification of genomic markers of drug sensitivity in cancer cells
MJ Garnett, EJ Edelman, SJ Heidorn, CD Greenman, A Dastur, KW Lau, ...
Nature 483 (7391), 570-575, 2012
25562012
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
J Zhang, FJ Adrián, W Jahnke, SW Cowan-Jacob, AG Li, RE Iacob, T Sim, ...
Nature 463 (7280), 501-506, 2010
6812010
Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
PS Hammerman, ML Sos, AH Ramos, C Xu, A Dutt, W Zhou, LE Brace, ...
Cancer discovery 1 (1), 78-89, 2011
5842011
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders
H Jiang, H He, Y Chen, W Huang, J Cheng, J Ye, A Wang, J Tao, C Wang, ...
Journal of Experimental Medicine 214 (11), 3219-3238, 2017
5752017
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
H He, H Jiang, Y Chen, J Ye, A Wang, C Wang, Q Liu, G Liang, X Deng, ...
Nature communications 9 (1), 2550, 2018
5152018
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
X Deng, N Dzamko, A Prescott, P Davies, Q Liu, Q Yang, JD Lee, ...
Nature chemical biology 7 (4), 203-205, 2011
4692011
Tranilast directly targets NLRP 3 to treat inflammasome‐driven diseases
Y Huang, H Jiang, Y Chen, X Wang, Y Yang, J Tao, X Deng, G Liang, ...
EMBO molecular medicine 10 (4), e8689, 2018
3752018
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
F Fan, Z He, LL Kong, Q Chen, Q Yuan, S Zhang, J Ye, H Liu, X Sun, ...
Science translational medicine 8 (352), 352ra108-352ra108, 2016
3272016
Low-dose metformin targets the lysosomal AMPK pathway through PEN2
T Ma, X Tian, B Zhang, M Li, Y Wang, C Yang, J Wu, X Wei, Q Qu, Y Yu, ...
Nature 603 (7899), 159-165, 2022
2572022
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein
Q Yang, X Deng, B Lu, M Cameron, C Fearns, MP Patricelli, JR Yates, ...
Cancer cell 18 (3), 258-267, 2010
2322010
Enantioselective synthesis of vinylcyclopropanes and vinylepoxides mediated by camphor-derived sulfur ylides: rationale of enantioselectivity, scope, and limitation
XM Deng, P Cai, S Ye, XL Sun, WW Liao, K Li, Y Tang, YD Wu, LX Dai
Journal of the American Chemical Society 128 (30), 9730-9740, 2006
2012006
GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor
AD Reith, P Bamborough, K Jandu, D Andreotti, L Mensah, P Dossang, ...
Bioorganic & medicinal chemistry letters 22 (17), 5625-5629, 2012
1702012
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis
H Wu, L Wei, F Fan, S Ji, S Zhang, J Geng, L Hong, X Fan, Q Chen, J Tian, ...
Nature communications 6 (1), 6239, 2015
1652015
Glycogen accumulation and phase separation drives liver tumor initiation
Q Liu, J Li, W Zhang, C Xiao, S Zhang, C Nian, J Li, D Su, L Chen, Q Zhao, ...
Cell 184 (22), 5559-5576. e19, 2021
1402021
Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2
S Zhang, Q Chen, Q Liu, Y Li, X Sun, L Hong, S Ji, C Liu, J Geng, ...
Cancer cell 31 (5), 669-684. e7, 2017
1352017
Brain penetrant LRRK2 inhibitor
HG Choi, J Zhang, X Deng, JM Hatcher, MP Patricelli, Z Zhao, DR Alessi, ...
ACS medicinal chemistry letters 3 (8), 658-662, 2012
1352012
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense
H Wu, Y Xiao, S Zhang, S Ji, L Wei, F Fan, J Geng, J Tian, X Sun, F Qin, ...
Cell reports 3 (5), 1663-1677, 2013
1342013
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors
CV Miduturu, X Deng, N Kwiatkowski, W Yang, L Brault, ...
Chemistry & biology 18 (7), 868-879, 2011
1312011
Rapid 3D printing of functional nanoparticle-enhanced conduits for effective nerve repair
J Tao, J Zhang, T Du, X Xu, X Deng, S Chen, J Liu, Y Chen, X Liu, ...
Acta biomaterialia 90, 49-59, 2019
1282019
Direct targeting of β-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt/β-catenin signaling
SY Hwang, X Deng, S Byun, C Lee, SJ Lee, H Suh, J Zhang, Q Kang, ...
Cell reports 16 (1), 28-36, 2016
1182016
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