Grzegorz Popowicz

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Citations	6588	3793
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Michael SattlerProfessor, Technical University of Munich & Helmholtz Center MunichVerified email at helmholtz-muenchen.de
Anna CzarnaUniwersytet JagiellońskiVerified email at uj.edu.pl
Grzegorz DubinJagiellonian University, Malopolska Centre of BiotechnologyVerified email at uj.edu.pl
Vishal C. KalelRuhr-University BochumVerified email at ruhr-uni-bochum.de
Kamyar HadianHelmholtz MunichVerified email at helmholtz-munich.de
Marta KolonkoPolitechnika WrocławskaVerified email at pwr.wroc.pl
Oliver PlettenburgDirektor, Institut für Medizinalchemie, Helmholtz Zentrum München, Professor für MedizinalchemieVerified email at helmholtz-muenchen.de
Krzysztof PyrcProfessor, virology, Jagiellonian UniversityVerified email at uj.edu.pl
Yonghua WangSchool of food science and engineering, South China University of TechnologyVerified email at scut.edu.cn
Roberto Fino, Dr.CADD Scientist at Johnson&Johnson Innovative Medicine, Antwerp regionVerified email at its.jnj.com
Filipe MenezesHelmholtz MunichVerified email at helmholtz-munich.de
David KoesAssociate Professor, University of PittsburghVerified email at pitt.edu
Leonidas EmmanouilidisETH ZurichVerified email at ethz.ch
Mark John BostockAstra ZenecaVerified email at astrazeneca.com
Jacek PlewkaJagiellonian UniversityVerified email at uj.edu.pl
Lutz WeberMolGenie, OntoChem, Alphaptose, NexusPharma, Morphochem, HoffmannLa Roche, Uni Leipzig, BME BudapestVerified email at molgenie.com
Shravan Kumar MishraAssociate Professor, Indian Institute of Science Education and Research (IISER) MohaliVerified email at iisermohali.ac.in
Gregory VerdineProfessor of Stem Cell and Regenerative Biology, Harvard UniversityVerified email at harvard.edu
Marcelino ArciniegaInstituto de Fisiología Celular, Universidad Autónoma de MéxicoVerified email at ifc.unam.mx
Igor V. TetkoBIGCHEM GmbH & Helmholtz MunichVerified email at helmholtz-munich.de

Grzegorz Popowicz

Group Leader, Helmholtz Zentrum München

Verified email at helmholtz-muenchen.de

structural biology drug discovery AI ML medicinal chemistry


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FSP1 is a glutathione-independent ferroptosis suppressor S Doll, FP Freitas, R Shah, M Aldrovandi, MC da Silva, I Ingold, ... Nature 575 (7784), 693-698, 2019	1870	2019
Filamins: promiscuous organizers of the cytoskeleton GM Popowicz, M Schleicher, AA Noegel, TA Holak Trends in biochemical sciences 31 (7), 411-419, 2006	343	2006
Structure of the stapled p53 peptide bound to Mdm2 S Baek, PS Kutchukian, GL Verdine, R Huber, TA Holak, KW Lee, ... Journal of the American Chemical Society 134 (1), 103-106, 2012	292	2012
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery GM Popowicz, A Czarna, S Wolf, K Wang, W Wang, A Dömling, TA Holak Cell cycle 9 (6), 1104-1111, 2010	285	2010
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain G Popowicz, A Czarna, T Holak Cell cycle 7 (15), 2441-2443, 2008	229	2008
The structure‐based design of MDM2/MDMX–p53 inhibitors gets serious GM Popowicz, A Dömling, TA Holak Angewandte Chemie International Edition 50 (12), 2680-2688, 2011	190	2011
Molecular basis for the inhibition of p53 by Mdmx GM Popowicz, A Czarna, U Rothweiler, A Szwagierczak, M Krajewski, ... Cell cycle 6 (19), 2386-2392, 2007	176	2007
Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins T Sitar, GM Popowicz, I Siwanowicz, R Huber, TA Holak Proceedings of the National Academy of Sciences 103 (35), 13028-13033, 2006	167	2006
Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53-Hdm2 antagonists A Czarna, B Beck, S Srivastava, G Popowicz, S Wolf, Y Huang, M Bista, ... Angewandte Chemie (International ed. in English) 49 (31), 5352, 2010	162	2010
The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization A Benzinger, GM Popowicz, JK Joy, S Majumdar, TA Holak, H Hermeking Cell research 15 (4), 219-227, 2005	154	2005
High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx A Czarna, GM Popowicz, A Pecak, S Wolf, G Dubin, TA Holak Cell cycle 8 (8), 1176-1184, 2009	125	2009
Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists D Koes, K Khoury, Y Huang, W Wang, M Bista, GM Popowicz, S Wolf, ... PloS one 7 (3), e32839, 2012	122	2012
Structural basis for the assembly of the Sxl–Unr translation regulatory complex J Hennig, C Militti, GM Popowicz, I Wang, M Sonntag, A Geerlof, F Gabel, ... Nature 515 (7526), 287-290, 2014	120	2014
Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing SK Mishra, T Ammon, GM Popowicz, M Krajewski, RJ Nagel, M Ares, ... Nature 474 (7350), 173-178, 2011	107	2011
Structural basis for the regulation of insulin-like growth factors by IGF binding proteins I Siwanowicz, GM Popowicz, M Wisniewska, R Huber, KP Kuenkele, ... Structure 13 (1), 155-167, 2005	107	2005
The p53-MDM2/MDMX axis–A chemotype perspective K Khoury, GM Popowicz, TA Holak, A Dömling MedChemComm 2 (4), 246-260, 2011	86	2011
Transient protein states in designing inhibitors of the MDM2-p53 interaction M Bista, S Wolf, K Khoury, K Kowalska, Y Huang, E Wrona, M Arciniega, ... Structure 21 (12), 2143-2151, 2013	82	2013
Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites M Dawidowski, L Emmanouilidis, VC Kalel, K Tripsianes, K Schorpp, ... Science 355 (6332), 1416-1420, 2017	80	2017
Functional and structural characterization of Spl proteases from Staphylococcus aureus GM Popowicz, G Dubin, J Stec-Niemczyk, A Czarna, A Dubin, J Potempa, ... Journal of molecular biology 358 (1), 270-279, 2006	80	2006
c-Abl phosphorylates Hdmx and regulates its interaction with p53 V Zuckerman, K Lenos, GM Popowicz, I Silberman, T Grossman, ... Journal of Biological Chemistry 284 (6), 4031-4039, 2009	77	2009

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