| Tracking protein aggregation and mislocalization in cells with flow cytometry YM Ramdzan, S Polling, CPZ Chia, IHW Ng, AR Ormsby, NP Croft, ... Nature methods 9 (5), 467-470, 2012 | 119 | 2012 |
| Huntingtin inclusions trigger cellular quiescence, deactivate apoptosis, and lead to delayed necrosis YM Ramdzan, MM Trubetskov, AR Ormsby, EA Newcombe, X Sui, ... Cell reports 19 (5), 919-927, 2017 | 112 | 2017 |
| Tadpole-like conformations of huntingtin exon 1 are characterized by conformational heterogeneity that persists regardless of polyglutamine length EA Newcombe, KM Ruff, A Sethi, AR Ormsby, YM Ramdzan, A Fox, ... Journal of molecular biology 430 (10), 1442-1458, 2018 | 65 | 2018 |
| Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src S Irtegun, RJ Wood, AR Ormsby, TD Mulhern, DM Hatters PloS one 8 (7), e71035, 2013 | 62 | 2013 |
| Sequence grammar underlying the unfolding and phase separation of globular proteins KM Ruff, YH Choi, D Cox, AR Ormsby, Y Myung, DB Ascher, SE Radford, ... Molecular Cell 82 (17), 3193-3208. e8, 2022 | 49 | 2022 |
| Widespread remodeling of proteome solubility in response to different protein homeostasis stresses X Sui, DEV Pires, AR Ormsby, D Cox, S Nie, G Vecchi, M Vendruscolo, ... Proceedings of the National Academy of Sciences 117 (5), 2422-2431, 2020 | 49 | 2020 |
| Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation S Polling, AR Ormsby, RJ Wood, K Lee, C Shoubridge, JN Hughes, ... Nature structural & molecular biology 22 (12), 1008-1015, 2015 | 49 | 2015 |
| A biosensor-based framework to measure latent proteostasis capacity RJ Wood, AR Ormsby, M Radwan, D Cox, A Sharma, T Vöpel, ... Nature communications 9 (1), 287, 2018 | 40 | 2018 |
| Arginine in C9ORF72 dipolypeptides mediates promiscuous proteome binding and multiple modes of toxicity M Radwan, CS Ang, AR Ormsby, D Cox, JC Daly, GE Reid, DM Hatters Molecular & Cellular Proteomics 19 (4), 640-654, 2020 | 31 | 2020 |
| A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70 AR Ormsby, YM Ramdzan, YF Mok, KD Jovanoski, DM Hatters Journal of Biological Chemistry 288 (52), 37192-37203, 2013 | 31 | 2013 |
| Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways NS Moily, AR Ormsby, A Stojilovic, YM Ramdzan, J Diesch, RD Hannan, ... Molecular and Cellular Neuroscience 83, 103-112, 2017 | 30 | 2017 |
| Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells S Büning, A Sharma, S Vachharajani, E Newcombe, A Ormsby, M Gao, ... Physical Chemistry Chemical Physics 19 (17), 10738-10747, 2017 | 25 | 2017 |
| Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate V Kriachkov, AR Ormsby, EP Kusnadi, HEG McWilliam, JD Mintern, ... Journal of Biological Chemistry 299 (1), 2023 | 11 | 2023 |
| Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA AR Ormsby, D Cox, J Daly, D Priest, E Hinde, DM Hatters Plos one 15 (7), e0233583, 2020 | 6 | 2020 |
| N-terminal fragments of huntingtin longer than residue 170 form visible aggregates independently to polyglutamine expansion MZ Chen, SA Mok, AR Ormsby, PJ Muchowski, DM Hatters Journal of Huntington's Disease 6 (1), 79-91, 2017 | 5 | 2017 |
| Replicative aging impedes stress-induced assembly of a key human protein disaggregase Y Mathangasinghe, N Alberts, C Rosado, D Cox, N Payne, AR Ormsby, ... | 3 | 2023 |
| A biosensor to gauge protein homeostasis resilience differences in the nucleus compared to cytosol of mammalian cells CB Raeburn, A Ormsby, NS Moily, D Cox, S Ebbinghaus, A Dickson, ... bioRxiv, 2021.04. 19.440383, 2021 | 3 | 2021 |
| Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli D Cox, AR Ormsby, GE Reid, DM Hatters npj Systems Biology and Applications 8 (1), 46, 2022 | 2 | 2022 |
| A biosensor of protein foldedness identifies increased “holdase” activity of chaperones in the nucleus following increased cytosolic protein aggregation CB Raeburn, AR Ormsby, D Cox, CA Gerak, C Makhoul, NS Moily, ... Journal of Biological Chemistry 298 (8), 2022 | 2 | 2022 |
| Measuring proteostasis capacity using transiently transfected bait proteins by flow cytometry D Hatters, R Wood, C Raeburn, A Ormsby, M Oliveberg, A Dickson | 1 | 2018 |
