| Why hydroxamates may not be the best histone deacetylase inhibitors—what some may have forgotten or would rather forget? S Shen, AP Kozikowski ChemMedChem 11 (1), 15-21, 2016 | 212 | 2016 |
| Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal Charcot–Marie–Tooth disease S Shen, V Benoy, JA Bergman, JH Kalin, M Frojuello, G Vistoli, W Haeck, ... ACS chemical neuroscience 7 (2), 240-258, 2016 | 108 | 2016 |
| A patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2014-2019) S Shen, AP Kozikowski Expert opinion on therapeutic patents 30 (2), 121-136, 2020 | 64 | 2020 |
| Discovery of a new isoxazole-3-hydroxamate-based histone deacetylase 6 inhibitor SS-208 with antitumor activity in syngeneic melanoma mouse models S Shen, M Hadley, K Ustinova, J Pavlicek, T Knox, S Noonepalle, ... Journal of medicinal chemistry 62 (18), 8557-8577, 2019 | 64 | 2019 |
| Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells H Zhu, Z Liu, L Tang, J Liu, M Zhou, F Xie, Z Wang, Y Wang, S Shen, L Hu, ... European journal of pharmacology 696 (1-3), 43-53, 2012 | 59 | 2012 |
| Structural and in vivo characterization of Tubastatin A, a widely used histone deacetylase 6 inhibitor S Shen, M Svoboda, G Zhang, MA Cavasin, L Motlova, TA McKinsey, ... ACS Medicinal Chemistry Letters 11 (5), 706-712, 2020 | 54 | 2020 |
| Brain penetrable histone deacetylase 6 inhibitor SW-100 ameliorates memory and learning impairments in a mouse model of fragile X syndrome AP Kozikowski, S Shen, M Pardo, MT Tavares, D Szarics, V Benoy, ... ACS chemical neuroscience 10 (3), 1679-1695, 2018 | 54 | 2018 |
| HDAC6 inhibition promotes α-tubulin acetylation and ameliorates CMT2A peripheral neuropathy in mice C Picci, VSC Wong, CJ Costa, MC McKinnon, DC Goldberg, M Swift, ... Experimental neurology 328, 113281, 2020 | 46 | 2020 |
| Identification of HDAC6‐Selective Inhibitors of Low Cancer Cell Cytotoxicity IN Gaisina, W Tueckmantel, A Ugolkov, S Shen, J Hoffen, O Dubrovskyi, ... ChemMedChem 11 (1), 81-92, 2016 | 43 | 2016 |
| Synthesis and pharmacological evaluation of selective histone deacetylase 6 inhibitors in melanoma models MT Tavares, S Shen, T Knox, M Hadley, Z Kutil, C Bařinka, A Villagra, ... ACS Medicinal Chemistry Letters 8 (10), 1031-1036, 2017 | 38 | 2017 |
| Rational design of suprastat: a novel selective histone deacetylase 6 inhibitor with the ability to potentiate immunotherapy in melanoma models S Noonepalle, S Shen, J Ptáček, MT Tavares, G Zhang, J Stránský, ... Journal of Medicinal Chemistry 63 (18), 10246-10262, 2020 | 35 | 2020 |
| Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK S Shen, J Zhuang, Y Chen, M Lei, J Chen, X Shen, L Hu Bioorganic & medicinal chemistry 21 (13), 3882-3893, 2013 | 32 | 2013 |
| Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors MT Tavares, AP Kozikowski, S Shen European journal of medicinal chemistry 209, 112887, 2021 | 31 | 2021 |
| Molecular basis for the selective inhibition of histone deacetylase 6 by a mercaptoacetamide inhibitor NJ Porter, S Shen, C Barinka, AP Kozikowski, DW Christianson ACS Medicinal Chemistry Letters 9 (12), 1301-1305, 2018 | 26 | 2018 |
| A remarkable difference that one fluorine atom confers on the mechanisms of inactivation of human ornithine aminotransferase by two cyclohexene analogues of γ-aminobutyric acid W Zhu, PF Doubleday, DS Catlin, PM Weerawarna, A Butrin, S Shen, ... Journal of the American Chemical Society 142 (10), 4892-4903, 2020 | 21 | 2020 |
| A facile and efficient method for the synthesis of solasodine from diosgenin GP Zhang, SD Shen, M Lei, LH Hu Tetrahedron 67 (33), 5894-5896, 2011 | 21 | 2011 |
| Synthesis and structure–activity relationships of boswellic acid derivatives as potent VEGFR-2 inhibitors S Shen, X Xu, Z Liu, J Liu, L Hu Bioorganic & Medicinal Chemistry 23 (9), 1982-1993, 2015 | 20 | 2015 |
| Tetrahydroquinoline-capped histone deacetylase 6 inhibitor SW-101 ameliorates pathological phenotypes in a Charcot–Marie–Tooth type 2A mouse model S Shen, C Picci, K Ustinova, V Benoy, Z Kutil, G Zhang, MT Tavares, ... Journal of Medicinal Chemistry 64 (8), 4810-4840, 2021 | 18 | 2021 |
| Novel one-pot synthesis of 2-substituted 3-alkoxyisoindolin-1-imine derivatives from 2-cyanobenzaldehyde, amine, and alcohol S Shen, X Xu, M Lei, L Hu Synthesis, 3543-3549, 2012 | 13 | 2012 |
| First total synthesis of salvianolic acid C, tournefolic acid A, and tournefolal SD Shen, GP Zhang, M Leib, LH Hu Arkivoc 6, 204-213, 2012 | 13 | 2012 |
Alejandro VillagraGeorgetown UniversityVerified email at georgetown.edu
