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Tito Borner
Tito Borner
Verified email at nursing.upenn.edu
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Year
GDF15 induces anorexia through nausea and emesis
T Borner, ED Shaulson, MY Ghidewon, AB Barnett, CC Horn, RP Doyle, ...
Cell metabolism 31 (2), 351-362. e5, 2020
1592020
GIP receptor agonism attenuates GLP-1 receptor agonist–induced nausea and emesis in preclinical models
T Borner, CE Geisler, SM Fortin, R Cosgrove, J Alsina-Fernandez, ...
Diabetes 70 (11), 2545-2553, 2021
772021
GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats
SM Fortin, RK Lipsky, R Lhamo, J Chen, E Kim, T Borner, HD Schmidt, ...
Science translational medicine 12 (533), eaay8071, 2020
692020
GDF15 induces an aversive visceral malaise state that drives anorexia and weight loss
T Borner, HS Wald, MY Ghidewon, B Zhang, Z Wu, BC De Jonghe, ...
Cell Reports 31 (3), 2020
622020
Anorexia‐cachexia syndrome in hepatoma tumour‐bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC‐1/GDF15
T Borner, M Arnold, J Ruud, SN Breit, W Langhans, TA Lutz, A Blomqvist, ...
Journal of cachexia, sarcopenia and muscle 8 (3), 417-427, 2017
432017
The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats
T Borner, L Loi, C Pietra, C Giuliano, TA Lutz, T Riediger
American Journal of Physiology-Regulatory, Integrative and Comparative …, 2016
332016
A vitamin B12 conjugate of exendin‐4 improves glucose tolerance without associated nausea or hypophagia in rodents
EG Mietlicki‐Baase, CG Liberini, JL Workinger, RL Bonaccorso, T Borner, ...
Diabetes, Obesity and Metabolism 20 (5), 1223-1234, 2018
302018
The role of GIP in the regulation of GLP-1 satiety and nausea
MR Hayes, T Borner, BC De Jonghe
Diabetes 70 (9), 1956-1961, 2021
292021
Brainstem GLP-1 signalling contributes to cancer anorexia-cachexia syndrome in the rat
T Borner, CG Liberini, TA Lutz, T Riediger
Neuropharmacology 131, 282-290, 2018
282018
GIPR agonism inhibits PYY-induced nausea-like behavior
RJ Samms, R Cosgrove, BM Snider, EC Furber, BA Droz, DA Briere, ...
Diabetes 71 (7), 1410-1423, 2022
272022
Lipopolysaccharide inhibits ghrelin-excited neurons of the arcuate nucleus and reduces food intake via central nitric oxide signaling
T Borner, S Pinkernell, TA Lutz, T Riediger
Brain, behavior, and immunity 26 (6), 867-879, 2012
242012
Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation
RM Leon, T Borner, DJ Reiner, LM Stein, R Lhamo, BC De Jonghe, ...
Neuropsychopharmacology 44 (10), 1742-1751, 2019
232019
The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats
CG Liberini, T Borner, CN Boyle, TA Lutz
Molecular metabolism 5 (10), 834-843, 2016
222016
Design and evaluation of peptide dual-agonists of GLP-1 and NPY2 receptors for glucoregulation and weight loss with mitigated nausea and emesis
BT Milliken, C Elfers, OG Chepurny, KS Chichura, IR Sweet, T Borner, ...
Journal of medicinal chemistry 64 (2), 1127-1138, 2021
212021
Glucagon‐like peptide‐1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?
T Borner, IC Tinsley, RP Doyle, MR Hayes, BC De Jonghe
British journal of pharmacology 179 (4), 542-556, 2022
202022
Corrination of a GLP-1 receptor agonist for glycemic control without emesis
T Borner, JL Workinger, IC Tinsley, SM Fortin, LM Stein, OG Chepurny, ...
Cell reports 31 (11), 2020
202020
Growth differentiation factor 15 (GDF15) and semaglutide inhibit food intake and body weight through largely distinct, additive mechanisms
M Ghidewon, HS Wald, AD McKnight, BC De Jonghe, DM Breen, ...
Diabetes, Obesity and Metabolism 24 (6), 1010-1020, 2022
162022
A second‐generation glucagon‐like peptide‐1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models
T Borner, ED Shaulson, IC Tinsley, LM Stein, CC Horn, MR Hayes, ...
Diabetes, Obesity and Metabolism 22 (10), 1729-1741, 2020
162020
Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats
RM Leon, T Borner, LM Stein, NA Urrutia, BC De Jonghe, HD Schmidt, ...
Neuropharmacology 187, 108477, 2021
92021
Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects
M Asker, JP Krieger, A Liles, IC Tinsley, T Borner, I Maric, S Doebley, ...
Diabetes, Obesity and Metabolism 25 (3), 856-877, 2023
82023
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