| Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants I Chachoua, C Pecquet, M El-Khoury, H Nivarthi, RI Albu, C Marty, ... Blood, The Journal of the American Society of Hematology 127 (10), 1325-1335, 2016 | 358 | 2016 |
| Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms JD Milosevic Feenstra, H Nivarthi, H Gisslinger, E Leroy, E Rumi, ... Blood, The Journal of the American Society of Hematology 127 (3), 325-332, 2016 | 305 | 2016 |
| Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis C Marty, C Pecquet, H Nivarthi, M El-Khoury, I Chachoua, M Tulliez, ... Blood, The Journal of the American Society of Hematology 127 (10), 1317-1324, 2016 | 285 | 2016 |
| Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients X Cabagnols, F Favale, F Pasquier, K Messaoudi, JP Defour, JC Ianotto, ... Blood, The Journal of the American Society of Hematology 127 (3), 333-342, 2016 | 200 | 2016 |
| Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants C Pecquet, I Chachoua, A Roy, T Balligand, G Vertenoeil, E Leroy, ... Blood, The Journal of the American Society of Hematology 133 (25), 2669-2681, 2019 | 90 | 2019 |
| WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating BA Scholz, N Sumida, CDM de Lima, I Chachoua, M Martino, I Tzelepis, ... Nature genetics 51 (12), 1723-1731, 2019 | 80 | 2019 |
| Oncogenic activation of MPL/thrombopoietin receptor by 17 mutations at W515: implications for myeloproliferative neoplasms JP Defour, I Chachoua, C Pecquet, SN Constantinescu Leukemia 30 (5), 1214-1216, 2016 | 78 | 2016 |
| Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin T Balligand, Y Achouri, C Pecquet, I Chachoua, H Nivarthi, C Marty, ... Leukemia 30 (8), 1775-1778, 2016 | 52 | 2016 |
| Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation M Girardot, C Pecquet, I Chachoua, J Van Hees, S Guibert, A Ferrant, ... Oncogene 34 (10), 1323-1332, 2015 | 38 | 2015 |
| Secreted mutant calreticulins as rogue cytokines trigger thrombopoietin receptor activation specifically in CALR mutated cells: perspectives for MPN therapy C Pecquet, T Balligand, I Chachoua, A Roy, G Vertenoeil, D Colau, ... Blood 132 (Supplement 1), 4-4, 2018 | 36 | 2018 |
| Calr mutants retroviral mouse models lead to a myeloproliferative neoplasm mimicking an essential thrombocythemia progressing to a myelofibrosis C Marty, N Harini, C Pecquet, I Chachoua, V Gryshkova, JL Villeval, ... Blood, The Journal of the American Society of Hematology 124 (21), 157-157, 2014 | 20 | 2014 |
| Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site I Chachoua, I Tzelepis, H Dai, JP Lim, A Lewandowska-Ronnegren, ... Nature communications 13 (1), 204, 2022 | 18 | 2022 |
| A p53-JAK-STAT connection involved in myeloproliferative neoplasm pathogenesis and progression to secondary acute myeloid leukemia H Goyal, I Chachoua, C Pecquet, W Vainchenker, SN Constantinescu Blood reviews 42, 100712, 2020 | 18 | 2020 |
| MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491 G Levy, S Carillo, B Papoular, B Cassinat, JM Zini, E Leroy, LN Varghese, ... Blood, The Journal of the American Society of Hematology 135 (12), 948-953, 2020 | 16 | 2020 |
| Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms C Pecquet, N Papadopoulos, T Balligand, I Chachoua, A Tisserand, ... Blood 141 (8), 917-929, 2023 | 14 | 2023 |
| Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation N Papadopoulos, A Nédélec, A Derenne, TA Şulea, C Pecquet, ... Nature communications 14 (1), 1881, 2023 | 7 | 2023 |
| Crispr/Cas9 engineered 61bp deletion in the Calr gene of mice leads to development of thrombocytosis T Balligand, Y Achouri, I Chachoua, C Pecquet, JP Defour, ... Blood 128 (22), 4274, 2016 | 6 | 2016 |
| Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms JDM Feenstra, H Nivarthi, H Gisslinger, E Leroy, E Rumi, I Chachoua, ... Blood 127 (3), 325-332, 2016 | 3 | 2016 |
| Structural Basis of Oncogenesis by Mutants of Calreticulin SN Constantinescu, N Papadopoulos, A Nédélec, A Derenne, TA Şulea, ... | 1 | 2022 |
| Whole Exome Sequencing Identifies Novel MPL and JAK2 M utations in Triple Negative Myeloproliferative Neoplasms JDM Feenstra, H Nivarthi, H Gisslinger, E Leroy, E Rumi, I Chachoua, ... Blood 126 (23), 606, 2015 | 1 | 2015 |
