| Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells L Bordone, MC Motta, F Picard, A Robinson, US Jhala, J Apfeld, ... PLoS biology 4 (2), e31, 2006 | 936 | 2006 |
| Substrate-specific activation of sirtuins by resveratrol M Kaeberlein, T McDonagh, B Heltweg, J Hixon, EA Westman, ... Journal of Biological Chemistry 280 (17), 17038-17045, 2005 | 930 | 2005 |
| The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans J Apfeld, G O'Connor, T McDonagh, PS DiStefano, R Curtis Genes & development 18 (24), 3004-3009, 2004 | 804 | 2004 |
| Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1 AD Napper, J Hixon, T McDonagh, K Keavey, JF Pons, J Barker, WT Yau, ... Journal of medicinal chemistry 48 (25), 8045-8054, 2005 | 571 | 2005 |
| Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage JM Solomon, R Pasupuleti, L Xu, T McDonagh, R Curtis, PS DiStefano, ... Molecular and cellular biology 26 (1), 28-38, 2006 | 554 | 2006 |
| Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibα complex reveals conformation differences with a complex bearing von Willebrand disease mutations JJ Dumas, R Kumar, T McDonagh, F Sullivan, ML Stahl, WS Somers, ... Journal of Biological Chemistry 279 (22), 23327-23334, 2004 | 239 | 2004 |
| Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites CR Flannery, W Zeng, C Corcoran, LA Collins-Racie, PS Chockalingam, ... Journal of Biological Chemistry 277 (45), 42775-42780, 2002 | 192 | 2002 |
| Independent folding and ligand specificity of the C2 calciumdependent lipid binding domain of cytosolic phospholipase A2 EA Nalefski, T McDonagh, W Somers, J Seehra, JJ Falke, JD Clark Journal of Biological Chemistry 273 (3), 1365-1372, 1998 | 162 | 1998 |
| Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2 GY Xu, T McDonagh, HA Yu, EA Nalefski, JD Clark, DA Cumming Journal of molecular biology 280 (3), 485-500, 1998 | 155 | 1998 |
| Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5 L Mosyak, K Georgiadis, T Shane, K Svenson, T Hebert, T McDonagh, ... Protein Science 17 (1), 16-21, 2008 | 146 | 2008 |
| Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice KA Longo, S Charoenthongtrakul, DJ Giuliana, EK Govek, T McDonagh, ... Regulatory peptides 150 (1-3), 55-61, 2008 | 123 | 2008 |
| Solution structure of recombinant human interleukin-6 GY Xu, HA Yu, J Hong, M Stahl, T McDonagh, LE Kay, DA Cumming Journal of molecular biology 268 (2), 468-481, 1997 | 117 | 1997 |
| SIRT1 shows no substrate specificity in vitro G Blander, J Olejnik, E Krzymanska-Olejnik, T McDonagh, M Haigis, ... Journal of biological Chemistry 280 (11), 9780-9785, 2005 | 114 | 2005 |
| ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain J Westling, AJ Fosang, K Last, VP Thompson, KN Tomkinson, T Hebert, ... Journal of Biological Chemistry 277 (18), 16059-16066, 2002 | 108 | 2002 |
| Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway DHH Tsao, T McDonagh, JB Telliez, S Hsu, K Malakian, GY Xu, LL Lin Molecular cell 5 (6), 1051-1057, 2000 | 71 | 2000 |
| The 24-hour respiratory quotient predicts energy intake and changes in body mass KA Longo, S Charoenthongtrakul, DJ Giuliana, EK Govek, T McDonagh, ... American Journal of Physiology-Regulatory, Integrative and Comparative …, 2010 | 57 | 2010 |
| SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183 JL Huber, MW McBurney, PS DiStefano, T McDonagh Future medicinal chemistry 2 (12), 1751-1759, 2010 | 53 | 2010 |
| Therapeutic compounds and related methods of use LJ Huber, TE McDonagh US Patent App. 12/387,960, 2010 | 48 | 2010 |
| Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps Y Qi, KA Longo, DJ Giuliana, S Gagne, T McDonagh, E Govek, A Nolan, ... BMC physiology 11, 1-9, 2011 | 45 | 2011 |
| Methods of treating a disorder A Napper, P DiStefano, R Curtis, J Hixon, T McDonagh US Patent App. 11/018,018, 2005 | 32 | 2005 |
