| Degradation of the BAF complex factor BRD9 by heterobifunctional ligands D Remillard, DL Buckley, J Paulk, GL Brien, M Sonnett, HS Seo, ... Angewandte Chemie International Edition 56 (21), 5738-5743, 2017 | 291 | 2017 |
| Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation GL Brien, G Gambero, DJ O'connell, E Jerman, SA Turner, CM Egan, ... Nature structural & molecular biology 19 (12), 1273-1281, 2012 | 275 | 2012 |
| Exploiting the epigenome to control cancer-promoting gene-expression programs GL Brien, DG Valerio, SA Armstrong Cancer cell 29 (4), 464-476, 2016 | 153 | 2016 |
| Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma GL Brien, D Remillard, J Shi, ML Hemming, J Chabon, K Wynne, ... Elife 7, e41305, 2018 | 149 | 2018 |
| Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer AP Bracken, GL Brien, CP Verrijzer Genes & development 33 (15-16), 936-959, 2019 | 139 | 2019 |
| NUP98 fusion proteins interact with the NSL and MLL1 complexes to drive leukemogenesis H Xu, DG Valerio, ME Eisold, A Sinha, RP Koche, W Hu, CW Chen, ... Cancer cell 30 (6), 863-878, 2016 | 124 | 2016 |
| Dynamic protein interactions of the polycomb repressive complex 2 during differentiation of pluripotent cells G Oliviero, GL Brien, A Waston, G Streubel, E Jerman, D Andrews, ... Molecular & Cellular Proteomics 15 (11), 3450-3460, 2016 | 76 | 2016 |
| Targeting chromatin complexes in fusion protein-driven malignancies GL Brien, K Stegmaier, SA Armstrong Nature Reviews Cancer 19 (5), 255-269, 2019 | 64 | 2019 |
| A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence GL Brien, E Healy, E Jerman, E Conway, E Fadda, D O'Donovan, ... Genes & development 29 (21), 2231-2243, 2015 | 42 | 2015 |
| Simultaneous disruption of PRC2 and enhancer function underlies histone H3. 3-K27M oncogenic activity in human hindbrain neural stem cells GL Brien, RB Bressan, C Monger, D Gannon, E Lagan, AM Doherty, ... Nature Genetics 53 (8), 1221-1232, 2021 | 38 | 2021 |
| Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node‐negative breast cancer patients F Lanigan, GL Brien, Y Fan, SF Madden, E Jerman, A Maratha, F Aloraifi, ... The FEBS journal 282 (18), 3455-3473, 2015 | 13 | 2015 |
| Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation GL Brien, AP Bracken Seminars in Cell & Developmental Biology 20 (7), 835-841, 2009 | 13 | 2009 |
| The PCL1-p53 axis promotes cellular quiescence GL Brien, AP Bracken Cell Cycle 15 (3), 305-306, 2016 | 7 | 2016 |
| The 3d genome: Ezh2 comes into the fold GL Brien, AP Bracken Trends in Molecular Medicine 25 (5), 362-365, 2019 | 1 | 2019 |
| Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma D Gannon, E Lagan, AJ Silva, P Bibawi, A Doherty, D Nimmo, R McCole, ... bioRxiv, 2023.12. 02.569451, 2023 | | 2023 |
| EZH1-PRC2 Identifies a Potential Reservoir for Disease Relapse in Quiescent Cancer Cells Refractory to EZH2 Enzymatic Inhibition E Healy, R McCole, C Monger, J Nolan, E Conway, G Brien, C Wang, ... Blood 140 (Supplement 1), 3049-3050, 2022 | | 2022 |
| The Role of Polycomb Repressive Complex 2 Associated Proteins in Mediating Complex Recruitment GL Brien Trinity College Dublin, 2013 | | 2013 |
| Canonical PRC1 Recruitment Is Promoted by EZH1-PRC2 Independent of H3K27me3 in Quiescent Cells E Healy, R McCole, C Monger, G Brien, C Wang, HK Neikes, F Potjewyd, ... Available at SSRN 4089979, 0 | | |
| Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to ESC genes during differentiation GL Brien, G Gambero, DJ O'Connell, E Jerman, SA Turner, CM Egan, ... | | |
