| Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ... Cell metabolism 7 (1), 45-56, 2008 | 2128 | 2008 |
| Drug‐induced liver injury: Advances in mechanistic understanding that will inform risk management M Mosedale, PB Watkins Clinical Pharmacology & Therapeutics 101 (4), 469-480, 2017 | 203 | 2017 |
| PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans TR Koves, LM Sparks, JP Kovalik, M Mosedale, R Arumugam, KL DeBalsi, ... Journal of lipid research 54 (2), 522-534, 2013 | 119 | 2013 |
| Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice RJ Church, DM Gatti, TJ Urban, N Long, X Yang, Q Shi, JS Eaddy, ... Food and Chemical Toxicology 76, 19-26, 2015 | 98 | 2015 |
| Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic β-cells and the involvement of neuroligin in insulin secretion AT Suckow, D Comoletti, MA Waldrop, M Mosedale, S Egodage, P Taylor, ... Endocrinology 149 (12), 6006-6017, 2008 | 92 | 2008 |
| Application of a mechanistic model to evaluate putative mechanisms of tolvaptan drug-induced liver injury and identify patient susceptibility factors JL Woodhead, WJ Brock, SE Roth, SE Shoaf, KLR Brouwer, R Church, ... Toxicological Sciences 155 (1), 61-74, 2017 | 88 | 2017 |
| Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury? NS Holman, M Mosedale, KK Wolf, EL LeCluyse, PB Watkins Toxicological Sciences 151 (2), 365-375, 2016 | 78 | 2016 |
| Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis LM Norona, DG Nguyen, DA Gerber, SC Presnell, M Mosedale, ... PLoS One 14 (1), e0208958, 2019 | 70 | 2019 |
| Editor’s Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach M Mosedale, Y Kim, WJ Brock, SE Roth, T Wiltshire, JS Eaddy, GR Keele, ... Toxicological Sciences 156 (2), 438-454, 2017 | 58 | 2017 |
| A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis RJ Church, H Wu, M Mosedale, SJ Sumner, W Pathmasiri, CL Kurtz, ... Toxicological Sciences 140 (2), 481-492, 2014 | 53 | 2014 |
| miR-122 release in exosomes precedes overt tolvaptan-induced necrosis in a primary human hepatocyte micropatterned coculture model M Mosedale, JS Eaddy, OJ Trask Jr, NS Holman, KK Wolf, E LeCluyse, ... Toxicological Sciences 161 (1), 149-158, 2018 | 48 | 2018 |
| Neurexin-1α contributes to insulin-containing secretory granule docking M Mosedale, S Egodage, RC Calma, NW Chi, SD Chessler Journal of Biological Chemistry 287 (9), 6350-6361, 2012 | 44 | 2012 |
| Understanding idiosyncratic toxicity: lessons learned from drug-induced liver injury M Mosedale, PB Watkins Journal of medicinal chemistry 63 (12), 6436-6461, 2020 | 41 | 2020 |
| Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875 … DM Longo, JL Woodhead, P Walker, K Herédi-Szabó, K Mogyorósi, ... Toxicological Sciences 167 (2), 458-467, 2019 | 41 | 2019 |
| Refining liver safety risk assessment: Application of mechanistic modeling and serum biomarkers to cimaglermin alfa (GGF2) clinical trials DM Longo, GT Generaux, BA Howell, SQ Siler, DJ Antoine, D Button, ... Clinical Pharmacology & Therapeutics 102 (6), 961-969, 2017 | 35 | 2017 |
| Hepatocyte-derived exosomes promote liver immune tolerance: Possible implications for idiosyncratic drug-induced liver injury NS Holman, RJ Church, M Nautiyal, KA Rose, SE Thacker, MA Otieno, ... Toxicological Sciences 170 (2), 499-508, 2019 | 34 | 2019 |
| Pregnancy-related hormones increase nifedipine metabolism in human hepatocytes by inducing CYP3A4 expression R Khatri, N Kulick, RJB Rementer, JK Fallon, C Sykes, AP Schauer, ... Journal of Pharmaceutical Sciences 110 (1), 412-421, 2021 | 21 | 2021 |
| Identification of Candidate Risk Factor Genes for Human Idelalisib Toxicity Using a Collaborative Cross Approach M Mosedale, Y Cai, JS Eaddy, RW Corty, M Nautiyal, PB Watkins, ... Toxicological Sciences 172 (2), 265-278, 2019 | 20 | 2019 |
| Transient changes in hepatic physiology that alter bilirubin and bile acid transport may explain elevations in liver chemistries observed in clinical trials of GGF2 … M Mosedale, D Button, JP Jackson, KM Freeman, KR Brouwer, ... Toxicological Sciences 161 (2), 401-411, 2018 | 20 | 2018 |
| Tolvaptan-and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury A Gibson, S Hammond, K Jaruthamsophon, S Roth, M Mosedale, ... Chemical research in toxicology 33 (11), 2745-2748, 2020 | 16 | 2020 |
