| Structural basis for allosteric PARP-1 retention on DNA breaks L Zandarashvili, MF Langelier, UK Velagapudi, MA Hancock, JD Steffen, ... Science 368 (6486), eaax6367, 2020 | 228 | 2020 |
| NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains MF Langelier, L Zandarashvili, PM Aguiar, BE Black, JM Pascal Nature communications 9 (1), 844, 2018 | 192 | 2018 |
| Asymmetrical roles of zinc fingers in dynamic DNA-scanning process by the inducible transcription factor Egr-1 L Zandarashvili, D Vuzman, A Esadze, Y Takayama, D Sahu, Y Levy, ... Proceedings of the National Academy of Sciences 109 (26), E1724-E1732, 2012 | 114 | 2012 |
| Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensemble L Zandarashvili, A Esadze, D Vuzman, CA Kemme, Y Levy, J Iwahara Proceedings of the National Academy of Sciences 112 (37), E5142-E5149, 2015 | 102 | 2015 |
| Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy L Zandarashvili, D Sahu, K Lee, YS Lee, P Singh, K Rajarathnam, ... Journal of Biological Chemistry 288 (17), 11621-11627, 2013 | 90 | 2013 |
| Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition LY Guo, PK Allu, L Zandarashvili, KL McKinley, N Sekulic, ... Nature communications 8 (1), 15775, 2017 | 83 | 2017 |
| Changes in conformational dynamics of basic side chains upon protein–DNA association A Esadze, C Chen, L Zandarashvili, S Roy, BM Pettitt, J Iwahara Nucleic acids research 44 (14), 6961-6970, 2016 | 58 | 2016 |
| Entropic enhancement of protein-DNA affinity by oxygen-to-sulfur substitution in DNA phosphate L Zandarashvili, D Nguyen, KM Anderson, MA White, DG Gorenstein, ... Biophysical journal 109 (5), 1026-1037, 2015 | 54 | 2015 |
| Signature of Mobile Hydrogen Bonding of Lysine Side Chains from Long-Range 15N–13C Scalar J-Couplings and Computation L Zandarashvili, DW Li, T Wang, R Brüschweiler, J Iwahara Journal of the American Chemical Society 133 (24), 9192-9195, 2011 | 47 | 2011 |
| Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1 L Zandarashvili, MA White, A Esadze, J Iwahara FEBS letters 589 (15), 1748-1753, 2015 | 45 | 2015 |
| Dynamic equilibria of short-range electrostatic interactions at molecular interfaces of protein–DNA complexes C Chen, A Esadze, L Zandarashvili, D Nguyen, BM Pettitt, J Iwahara The journal of physical chemistry letters 6 (14), 2733-2737, 2015 | 40 | 2015 |
| Hydrogen-deuterium exchange coupled to top-and middle-down mass spectrometry reveals histone tail dynamics before and after nucleosome assembly KR Karch, M Coradin, L Zandarashvili, ZY Kan, M Gerace, SW Englander, ... Structure 26 (12), 1651-1663. e3, 2018 | 38 | 2018 |
| Physicochemical properties of ion pairs of biological macromolecules J Iwahara, A Esadze, L Zandarashvili Biomolecules 5 (4), 2435-2463, 2015 | 38 | 2015 |
| NMR studies on the dynamics of hydrogen bonds and ion pairs involving lysine side chains of proteins L Zandarashvili, A Esadze, J Iwahara Advances in Protein Chemistry and Structural Biology 93, 37-80, 2013 | 34 | 2013 |
| Temperature Dependence of Internal Motions of Protein Side-Chain NH3+ Groups: Insight into Energy Barriers for Transient Breakage of Hydrogen Bonds L Zandarashvili, J Iwahara Biochemistry 54 (2), 538-545, 2015 | 26 | 2015 |
| Effective strategy to assign 1H-15N heteronuclear correlation NMR signals from lysine side-chain NH3 + groups of proteins at low temperature A Esadze, L Zandarashvili, J Iwahara Journal of biomolecular NMR 60, 23-27, 2014 | 20 | 2014 |
| Stereospecific Effects of Oxygen‐to‐Sulfur Substitution in DNA Phosphate on Ion Pair Dynamics and Protein–DNA Affinity D Nguyen, L Zandarashvili, MA White, J Iwahara Chembiochem 17 (17), 1636-1642, 2016 | 18 | 2016 |
| Residence times of molecular complexes in solution from NMR data of intermolecular hydrogen-bond scalar coupling L Zandarashvili, A Esadze, CA Kemme, A Chattopadhyay, D Nguyen, ... The journal of physical chemistry letters 7 (5), 820-824, 2016 | 16 | 2016 |
| A chemical approach for site-specific identification of NMR signals from protein side-chain NH3 + groups forming intermolecular ion pairs in protein … KM Anderson, D Nguyen, A Esadze, L Zandrashvili, DG Gorenstein, ... Journal of biomolecular NMR 62, 1-5, 2015 | 14 | 2015 |
| NMR-based investigations into target DNA search processes of proteins J Iwahara, L Zandarashvili, CA Kemme, A Esadze Methods 148, 57-66, 2018 | 13 | 2018 |
Alexandre EsadzeJHMI SOM dept of PharmacologyVerified email at jhmi.edu
