| Drug− protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development DC Evans, AP Watt, DA Nicoll-Griffith, TA Baillie Chemical research in toxicology 17 (1), 3-16, 2004 | 814 | 2004 |
| Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved … MB van Niel, I Collins, MS Beer, HB Broughton, SKF Cheng, ... Journal of medicinal chemistry 42 (12), 2087-2104, 1999 | 227 | 1999 |
| Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor S Patel, S Freedman, KL Chapman, F Emms, AE Fletcher, M Knowles, ... Journal of Pharmacology and Experimental Therapeutics 283 (2), 636-647, 1997 | 201 | 1997 |
| Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists M Rowley, JJ Kulagowski, AP Watt, D Rathbone, GI Stevenson, ... Journal of medicinal chemistry 40 (25), 4053-4068, 1997 | 171 | 1997 |
| Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC− MS/MS AP Watt, D Morrison, KL Locker, DC Evans Analytical Chemistry 72 (5), 979-984, 2000 | 153 | 2000 |
| Total synthesis and determination of the absolute configuration of epibatidine SR Fletcher, R Baker, MS Chambers, RH Herbert, SC Hobbs, SR Thomas, ... The Journal of Organic Chemistry 59 (7), 1771-1778, 1994 | 147 | 1994 |
| Controlled Modification of Acidity in Cholecystokinin B Receptor Antagonists: N-(1,4-Benzodiazepin-3-yl)-N ‘-[3-(tetrazol-5-ylamino)phenyl]ureas JL Castro, RG Ball, HB Broughton, MGN Russell, D Rathbone, AP Watt, ... Journal of medicinal chemistry 39 (4), 842-849, 1996 | 121 | 1996 |
| Chiral Base-Mediated Asymmetric Synthesis of Tricarbonyl (. eta. 6-arene) chromium Complexes DA Price, NS Simpkins, AM MacLeod, AP Watt The Journal of Organic Chemistry 59 (8), 1961-1962, 1994 | 114 | 1994 |
| Chiral base mediated asymmetric synthesis of tricarbonyl (η 6-arene) chromium complexes RA Ewin, AM MacLeod, DA Price, NS Simpkins, AP Watt Journal of the Chemical Society, Perkin Transactions 1, 401-416, 1997 | 104 | 1997 |
| In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L‐690,330 JR Atack, SM Cook, AP Watt, SR Fletcher, CI Ragan Journal of neurochemistry 60 (2), 652-658, 1993 | 99 | 1993 |
| Metabolite identification in drug discovery. AP Watt, RJ Mortishire-Smith, U Gerhard, SR Thomas Current opinion in drug discovery & development 6 (1), 57-65, 2003 | 95 | 2003 |
| Synthesis and serotonergic activity of N, N-dimethyl-2-[5-(1, 2, 4-triazol-1-ylmethyl)-1H-indol-3-yl] ethylamine and analogs: Potent agonists for 5-HT1D receptors LJ Street, R Baker, WB Davey, AR Guiblin, RA Jelley, AJ Reeve, ... Journal of medicinal chemistry 38 (10), 1799-1810, 1995 | 91 | 1995 |
| An increased throughput method for the determination of partition coefficients L Hitzel, AP Watt, KL Locker Pharmaceutical research 17, 1389-1395, 2000 | 89 | 2000 |
| Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery AP Watt, D Morrison, DC Evans Drug discovery today 5 (1), 17-24, 2000 | 86 | 2000 |
| 2-Aryl indole NK1 receptor antagonists: Optimisation of indole substitution LC Cooper, GG Chicchi, K Dinnell, JM Elliott, GJ Hollingworth, MM Kurtz, ... Bioorganic & medicinal chemistry letters 11 (9), 1233-1236, 2001 | 85 | 2001 |
| High-affinity and potent, water-soluble 5-amino-1, 4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group GA Showell, S Bourrain, JG Neduvelil, SR Fletcher, R Baker, AP Watt, ... Journal of medicinal chemistry 37 (6), 719-721, 1994 | 83 | 1994 |
| N-Heteroaryl-2-phenyl-3-(benzyloxy)piperidines: A Novel Class of Potent Orally Active Human NK1 Antagonists T Ladduwahetty, R Baker, MA Cascieri, MS Chambers, K Haworth, ... Journal of medicinal chemistry 39 (15), 2907-2914, 1996 | 79 | 1996 |
| A proteomic investigation of drug-induced steatosis in rat liver G Meneses-Lorente, PC Guest, J Lawrence, N Muniappa, MR Knowles, ... Chemical research in toxicology 17 (5), 605-612, 2004 | 73 | 2004 |
| A study of the synthesis and racemisation of a chiral lithiated tricarbonyl (η6-anisole) chromium complex DA Price, NS Simpkins, AM MacLeod, AP Watt Tetrahedron letters 35 (33), 6159-6162, 1994 | 73 | 1994 |
| A quantitative high-throughput trapping assay as a measurement of potential for bioactivation G Meneses-Lorente, MZ Sakatis, T Schulz-Utermoehl, C De Nardi, ... Analytical biochemistry 351 (2), 266-272, 2006 | 63 | 2006 |
