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Cris Van Hout
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Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease
FE Dewey, V Gusarova, RL Dunbar, C O’Dushlaine, C Schurmann, ...
New England Journal of Medicine 377 (3), 211-221, 2017
7592017
Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
FE Dewey, MF Murray, JD Overton, L Habegger, JB Leader, SN Fetterolf, ...
Science 354 (6319), aaf6814, 2016
5492016
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
FE Dewey, V Gusarova, C O’Dushlaine, O Gottesman, J Trejos, C Hunt, ...
New England Journal of Medicine 374 (12), 1123-1133, 2016
4962016
Exome sequencing and characterization of 49,960 individuals in the UK Biobank
CV Van Hout, I Tachmazidou, JD Backman, JD Hoffman, D Liu, ...
Nature 586 (7831), 749-756, 2020
3912020
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank
JD Szustakowski, S Balasubramanian, E Kvikstad, S Khalid, PG Bronson, ...
Nature genetics 53 (7), 942-948, 2021
2782021
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity
P Akbari, A Gilani, O Sosina, JA Kosmicki, L Khrimian, YY Fang, ...
Science 373 (6550), eabf8683, 2021
1612021
Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance
RC Adam, IJ Mintah, CA Alexa-Braun, LM Shihanian, JS Lee, P Banerjee, ...
Journal of lipid research 61 (9), 1271-1286, 2020
1382020
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
V Gusarova, C O’Dushlaine, TM Teslovich, PN Benotti, T Mirshahi, ...
Nature communications 9 (1), 2252, 2018
1262018
Whole exome sequencing and characterization of coding variation in 49,960 individuals in the UK Biobank
CV Van Hout, I Tachmazidou, JD Backman, JX Hoffman, B Ye, AK Pandey, ...
BioRxiv, 572347, 2019
1102019
Clinical and molecular prevalence of lipodystrophy in an unascertained large clinical care cohort
C Gonzaga-Jauregui, W Ge, J Staples, C Van Hout, A Yadav, R Colonie, ...
Diabetes 69 (2), 249-258, 2020
602020
Genomic diagnostics within a medically underserved population: efficacy and implications
KA Strauss, C Gonzaga-Jauregui, KW Brigatti, KB Williams, AK King, ...
Genetics in Medicine 20 (1), 31-41, 2018
542018
Long-term RNA interference from optimized siRNA expression constructs in adult mice
CI Wooddell, CV Van Hout, T Reppen, DL Lewis, H Herweijer
Biochemical and biophysical research communications 334 (1), 117-127, 2005
522005
Profiling and leveraging relatedness in a precision medicine cohort of 92,455 exomes
J Staples, EK Maxwell, N Gosalia, C Gonzaga-Jauregui, C Snyder, ...
The American Journal of Human Genetics 102 (5), 874-889, 2018
512018
Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease
JE Horowitz, N Warner, J Staples, E Crowley, N Gosalia, R Murchie, ...
Scientific reports 11 (1), 5595, 2021
472021
Exploiting the enzymatic recognition of an unnatural base pair to develop a universal genetic analysis system
MJ Moser, DJ Marshall, JK Grenier, CD Kieffer, AA Killeen, JL Ptacin, ...
Clinical chemistry 49 (3), 407-414, 2003
452003
Leveraging phenotypic variability to identify genetic interactions in human phenotypes
AR Marderstein, ER Davenport, S Kulm, CV Van Hout, O Elemento, ...
The American Journal of Human Genetics 108 (1), 49-67, 2021
442021
Using Mendelian inheritance to improve high-throughput SNP discovery
N Chen, CV Van Hout, S Gottipati, AG Clark
Genetics 198 (3), 847-857, 2014
372014
Determinants of blood pressure response to low‐salt intake in a healthy adult population
ME Montasser, JA Douglas, MH Roy‐Gagnon, CV Van Hout, MR Weir, ...
The Journal of Clinical Hypertension 13 (11), 795-800, 2011
282011
Integrating clinical laboratory measures and ICD-9 code diagnoses in phenome-wide association studies
A Verma, JB Leader, SS Verma, A Frase, J Wallace, S Dudek, DR Lavage, ...
Biocomputing 2016: Proceedings of the Pacific Symposium, 168-179, 2016
212016
Population genomic analysis of 962 whole genome sequences of humans reveals natural selection in non-coding regions
F Yu, J Lu, X Liu, E Gazave, D Chang, S Raj, H Hunter-Zinck, R Blekhman, ...
PLoS One 10 (3), e0121644, 2015
162015
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