| Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action CB Chan, D De Leo, JW Joseph, TS McQuaid, XF Ha, F Xu, RG Tsushima, ... Diabetes 50 (6), 1302-1310, 2001 | 481 | 2001 |
| Glucose-sensing mechanisms in pancreatic β-cells PE MacDonald, JW Joseph, P Rorsman Philosophical Transactions of the Royal Society B: Biological Sciences 360 …, 2005 | 464 | 2005 |
| Epac-selective cAMP analog 8-pCPT-2′-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic β-cells G Kang, JW Joseph, OG Chepurny, M Monaco, MB Wheeler, JL Bos, ... Journal of Biological Chemistry 278 (10), 8279-8285, 2003 | 384 | 2003 |
| Metabolic cycling in control of glucose-stimulated insulin secretion MV Jensen, JW Joseph, SM Ronnebaum, SC Burgess, AD Sherry, ... American Journal of Physiology-Endocrinology and Metabolism 295 (6), E1287-E1297, 2008 | 329 | 2008 |
| Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet JW Joseph, V Koshkin, CY Zhang, J Wang, BB Lowell, CB Chan, ... Diabetes 51 (11), 3211-3219, 2002 | 301 | 2002 |
| Free fatty acid-induced β-cell defects are dependent on uncoupling protein 2 expression JW Joseph, V Koshkin, MC Saleh, WI Sivitz, CY Zhang, BB Lowell, ... Journal of Biological Chemistry 279 (49), 51049-51056, 2004 | 290 | 2004 |
| A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion SM Ronnebaum, O Ilkayeva, SC Burgess, JW Joseph, D Lu, RD Stevens, ... Journal of Biological Chemistry 281 (41), 30593-30602, 2006 | 269 | 2006 |
| Peroxisome proliferator–activated receptor-α agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis H Kim, M Haluzik, Z Asghar, D Yau, JW Joseph, AM Fernandez, ... Diabetes 52 (7), 1770-1778, 2003 | 217 | 2003 |
| Inhibition of Kv2. 1 voltage-dependent K+ channels in pancreatic β-cells enhances glucose-dependent insulin secretion PE MacDonald, S Sewing, J Wang, JW Joseph, SR Smukler, ... Journal of Biological Chemistry 277 (47), 44938-44945, 2002 | 213 | 2002 |
| The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion JW Joseph, MV Jensen, O Ilkayeva, F Palmieri, C Alárcon, CJ Rhodes, ... Journal of Biological Chemistry 281 (47), 35624-35632, 2006 | 191 | 2006 |
| Targeting mitochondria with avocatin B induces selective leukemia cell death EA Lee, L Angka, SG Rota, T Hanlon, A Mitchell, R Hurren, XM Wang, ... Cancer research 75 (12), 2478-2488, 2015 | 169 | 2015 |
| Compensatory responses to pyruvate carboxylase suppression in islet β-cells: Preservation of glucose-stimulated insulin secretion MV Jensen, JW Joseph, O Ilkayeva, S Burgess, D Lu, SM Ronnebaum, ... Journal of Biological Chemistry 281 (31), 22342-22351, 2006 | 166 | 2006 |
| Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion JN Patterson, K Cousteils, JW Lou, JEM Fox, PE MacDonald, JW Joseph Journal of Biological Chemistry 289 (19), 13335-13346, 2014 | 102 | 2014 |
| The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing L Luu, FF Dai, KJ Prentice, X Huang, AB Hardy, JB Hansen, Y Liu, ... Diabetologia 56, 2010-2020, 2013 | 89 | 2013 |
| Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice L Héron-Milhavet, M Haluzik, S Yakar, O Gavrilova, S Pack, WC Jou, ... Endocrinology 145 (10), 4667-4676, 2004 | 86 | 2004 |
| The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose-and glutamine-stimulated insulin secretion ML Odegaard, JW Joseph, MV Jensen, D Lu, O Ilkayeva, SM Ronnebaum, ... Journal of biological chemistry 285 (22), 16530-16537, 2010 | 79 | 2010 |
| Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion JW Joseph, ML Odegaard, SM Ronnebaum, SC Burgess, J Muehlbauer, ... Journal of biological chemistry 282 (43), 31592-31600, 2007 | 74 | 2007 |
| A method for mouse pancreatic islet isolation and intracellular cAMP determination JC Neuman, NA Truchan, JW Joseph, ME Kimple JoVE (Journal of Visualized Experiments), e50374, 2014 | 66 | 2014 |
| Mitochondrial glutathione transport is a key determinant of neuronal susceptibility to oxidative and nitrosative stress HM Wilkins, D Kirchhof, E Manning, JW Joseph, DA Linseman Journal of Biological Chemistry 288 (7), 5091-5101, 2013 | 66 | 2013 |
| Oral delivery of glucagon-like peptide-1 in a modified polymer preparation normalizes basal glycaemia in diabetic db/db mice JW Joseph, J Kalitsky, S St-Pierre, PL Brubaker Diabetologia 43, 1319-1328, 2000 | 64 | 2000 |
Catherine Chanuniversity of albertaVerified email at ualberta.ca
