| Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer V Abkevich, KM Timms, BT Hennessy, J Potter, MS Carey, LA Meyer, ... British journal of cancer 107 (10), 1776-1782, 2012 | 747 | 2012 |
| Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ... Science 370 (6521), eabe9403, 2020 | 631 | 2020 |
| The role of metabolic activation in drug-induced hepatotoxicity BK Park, NR Kitteringham, JL Maggs, M Pirmohamed, DP Williams Annu. Rev. Pharmacol. Toxicol. 45 (1), 177-202, 2005 | 591 | 2005 |
| Managing the challenge of chemically reactive metabolites in drug development BK Park, A Boobis, S Clarke, CEP Goldring, D Jones, JG Kenna, ... Nature Reviews Drug Discovery 10 (4), 292-306, 2011 | 489 | 2011 |
| The UK‐PBC risk scores: derivation and validation of a scoring system for long‐term prediction of end‐stage liver disease in primary biliary cholangitis M Carbone, SJ Sharp, S Flack, D Paximadas, K Spiess, C Adgey, ... Hepatology 63 (3), 930-950, 2016 | 380 | 2016 |
| RETRACTED: molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity DJ Antoine, RE Jenkins, JW Dear, DP Williams, MR McGill, MR Sharpe, ... Journal of hepatology 56 (5), 1070-1079, 2012 | 376 | 2012 |
| Metabolism and bioactivation of clozapine by human liver in vitro. M Pirmohamed, D Williams, S Madden, E Templeton, BK Park Journal of Pharmacology and Experimental Therapeutics 272 (3), 984-990, 1995 | 347 | 1995 |
| Reproducing human and cross-species drug toxicities using a Liver-Chip KJ Jang, MA Otieno, J Ronxhi, HK Lim, L Ewart, KR Kodella, ... Science translational medicine 11 (517), eaax5516, 2019 | 345 | 2019 |
| Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter study CC Bell, ACA Dankers, VM Lauschke, R Sison-Young, R Jenkins, ... Toxicological Sciences 162 (2), 655-666, 2018 | 281 | 2018 |
| Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury WR Proctor, AJ Foster, J Vogt, C Summers, B Middleton, MA Pilling, ... Archives of toxicology 91, 2849-2863, 2017 | 276 | 2017 |
| High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo DJ Antoine, DP Williams, A Kipar, RE Jenkins, SL Regan, JG Sathish, ... Toxicological sciences 112 (2), 521-531, 2009 | 261 | 2009 |
| Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice CEP Goldring, NR Kitteringham, R Elsby, LE Randle, YN Clement, ... Hepatology 39 (5), 1267-1276, 2004 | 246 | 2004 |
| PAC-Man study collaboration. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised … S Harvey, DA Harrison, M Singer, J Ashcroft, CM Jones, D Elbourne, ... Lancet 366 (9484), 472-477, 2005 | 222 | 2005 |
| Obstetric skills drills: evaluation of teaching methods L Birch, N Jones, PM Doyle, P Green, A McLaughlin, C Champney, ... Nurse education today 27 (8), 915-922, 2007 | 218 | 2007 |
| Acyl glucuronides: the good, the bad and the ugly SL Regan, JL Maggs, TG Hammond, C Lambert, DP Williams, BK Park Biopharmaceutics & drug disposition 31 (7), 367-395, 2010 | 198 | 2010 |
| Characterisation of the toxic metabolite (s) of naphthalene AS Wilson, CD Davis, DP Williams, AR Buckpitt, M Pirmohamed, BK Park Toxicology 114 (3), 233-242, 1996 | 198 | 1996 |
| Synergistic interactions between commonly used food additives in a developmental neurotoxicity test K Lau, WG McLean, DP Williams, CV Howard Toxicological sciences 90 (1), 178-187, 2006 | 196 | 2006 |
| Sarcopenia is a predictor of outcomes in very elderly patients undergoing emergency surgery Y Du, CJ Karvellas, V Baracos, DC Williams, RG Khadaroo, ESA Group Surgery 156 (3), 521-527, 2014 | 186 | 2014 |
| Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models RJ Weaver, EA Blomme, AE Chadwick, IM Copple, HHJ Gerets, ... Nature Reviews Drug Discovery 19 (2), 131-148, 2020 | 183 | 2020 |
| Role of reactive metabolites in drug-induced hepatotoxicity A Srivastava, JL Maggs, DJ Antoine, DP Williams, DA Smith, BK Park Adverse drug reactions, 165-194, 2010 | 173 | 2010 |
