| Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine AS Eustáquio, RP McGlinchey, Y Liu, C Hazzard, LL Beer, G Florova, ... Proceedings of the National Academy of Sciences 106 (30), 12295-12300, 2009 | 197 | 2009 |
| AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin SC Penchala, S Connelly, Y Wang, MS Park, L Zhao, A Baranczak, ... Proceedings of the National Academy of Sciences 110 (24), 9992-9997, 2013 | 168 | 2013 |
| Antimalarial activity of natural and synthetic prodiginines K Papireddy, M Smilkstein, JX Kelly, Shweta, SM Salem, M Alhamadsheh, ... Journal of medicinal chemistry 54 (15), 5296-5306, 2011 | 167 | 2011 |
| A biomimetic approach for enhancing the in vivo half-life of peptides SC Penchala, MR Miller, A Pal, J Dong, NR Madadi, J Xie, H Joo, J Tsai, ... Nature chemical biology 11 (10), 793-798, 2015 | 129 | 2015 |
| Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis SJ Mo, PK Sydor, C Corre, MM Alhamadsheh, AE Stanley, SW Haynes, ... Chemistry & biology 15 (2), 137-148, 2008 | 116 | 2008 |
| Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity MM Alhamadsheh, S Connelly, A Cho, N Reixach, ET Powers, DW Pan, ... Science translational medicine 3 (97), 97ra81-97ra81, 2011 | 97 | 2011 |
| Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes MM Alhamadsheh, F Musayev, AA Komissarov, S Sachdeva, HT Wright, ... Chemistry & biology 14 (5), 513-524, 2007 | 74 | 2007 |
| Enthalpy-driven stabilization of transthyretin by AG10 mimics a naturally occurring genetic variant that protects from transthyretin amyloidosis M Miller, A Pal, W Albusairi, H Joo, B Pappas, MT Haque Tuhin, D Liang, ... Journal of medicinal chemistry 61 (17), 7862-7876, 2018 | 68 | 2018 |
| Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor JR Whicher, G Florova, PK Sydor, R Singh, M Alhamadsheh, GL Challis, ... Journal of Biological Chemistry 286 (25), 22558-22569, 2011 | 63 | 2011 |
| Modular Polyketide Synthases and cis Double Bond Formation: Establishment of Activated cis-3-Cyclohexylpropenoic Acid as the Diketide Intermediate in … MM Alhamadsheh, N Palaniappan, S DasChouduri, KA Reynolds Journal of the American Chemical Society 129 (7), 1910-1911, 2007 | 60 | 2007 |
| Unsymmetric aryl–alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis E Turos, KD Revell, P Ramaraju, DA Gergeres, K Greenhalgh, A Young, ... Bioorganic & medicinal chemistry 16 (13), 6501-6508, 2008 | 59 | 2008 |
| Synthesis and biological evaluation of novel sulfonyl-naphthalene-1, 4-diols as FabH inhibitors MM Alhamadsheh, NC Waters, S Sachdeva, P Lee, KA Reynolds Bioorganic & medicinal chemistry letters 18 (24), 6402-6405, 2008 | 54 | 2008 |
| Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli β-ketoacyl-ACP-synthase III (FabH) MM Alhamadsheh, NC Waters, DP Huddler, M Kreishman-Deitrick, ... Bioorganic & medicinal chemistry letters 17 (4), 879-883, 2007 | 53 | 2007 |
| cis-Δ2,3-Double Bond of Phoslactomycins Is Generated by a Post-PKS Tailoring Enzyme N Palaniappan, MM Alhamadsheh, KA Reynolds Journal of the American Chemical Society 130 (37), 12236-12237, 2008 | 47 | 2008 |
| Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH S Sachdeva, FN Musayev, MM Alhamadsheh, JN Scarsdale, HT Wright, ... Chemistry & biology 15 (4), 402-412, 2008 | 45 | 2008 |
| Total synthesis and selective activity of a new class of conformationally restrained epothilones MM Alhamadsheh, S Gupta, RA Hudson, L Perera, LMV Tillekeratne Chemistry–A European Journal 14 (2), 570-581, 2008 | 33 | 2008 |
| Design, total synthesis, and evaluation of novel open-chain epothilone analogues MM Alhamadsheh, RA Hudson, LM Viranga Tillekeratne Organic Letters 8 (4), 685-688, 2006 | 32 | 2006 |
| Identification of stabilizers of multimeric proteins IA Graef, M Alhamadsheh US Patent 8,877,795, 2014 | 24 | 2014 |
| Hydrophilic small molecules that harness transthyretin to enhance the safety and efficacy of targeted chemotherapeutic agents A Pal, W Albusairi, F Liu, MTH Tuhin, M Miller, D Liang, H Joo, TU Amin, ... Molecular Pharmaceutics 16 (7), 3237-3252, 2019 | 21 | 2019 |
| Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions IA Graef, MM Alhamadsheh US Patent 9,169,214, 2015 | 19 | 2015 |
