| Gasdermin D pore structure reveals preferential release of mature interleukin-1 S Xia, Z Zhang, VG Magupalli, JL Pablo, Y Dong, SM Vora, L Wang, ... Nature 593 (7860), 607-611, 2021 | 343 | 2021 |
| Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway YR Lee, M Chen, JD Lee, J Zhang, SY Lin, TM Fu, H Chen, T Ishikawa, ... Science 364 (6441), eaau0159, 2019 | 231 | 2019 |
| Molecular mechanism of V (D) J recombination from synaptic RAG1-RAG2 complex structures H Ru, MG Chambers, TM Fu, AB Tong, M Liao, H Wu Cell 163 (5), 1138-1152, 2015 | 186 | 2015 |
| Structural basis and functional role of intramembrane trimerization of the Fas/CD95 death receptor Q Fu, TM Fu, AC Cruz, P Sengupta, SK Thomas, S Wang, RM Siegel, ... Molecular cell 61 (4), 602-613, 2016 | 182 | 2016 |
| Cryo-EM structure of caspase-8 tandem DED filament reveals assembly and regulation mechanisms of the death-inducing signaling complex TM Fu, Y Li, A Lu, Z Li, PR Vajjhala, AC Cruz, DB Srivastava, F DiMaio, ... Molecular cell 64 (2), 236-250, 2016 | 165 | 2016 |
| Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism A Lu, Y Li, FI Schmidt, Q Yin, S Chen, TM Fu, AB Tong, HL Ploegh, Y Mao, ... Nature structural & molecular biology 23 (5), 416-425, 2016 | 157 | 2016 |
| Structures and gating mechanism of human TRPM2 L Wang, TM Fu, Y Zhou, S Xia, A Greka, H Wu Science 362 (6421), eaav4809, 2018 | 141 | 2018 |
| Higher-order clustering of the transmembrane anchor of DR5 drives signaling L Pan, TM Fu, W Zhao, L Zhao, W Chen, C Qiu, W Liu, Z Liu, A Piai, Q Fu, ... Cell 176 (6), 1477-1489. e14, 2019 | 126 | 2019 |
| Structural biology of innate immunity Q Yin, TM Fu, J Li, H Wu Annual review of immunology 33, 393-416, 2015 | 119 | 2015 |
| Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 Y Li, TM Fu, A Lu, K Witt, J Ruan, C Shen, H Wu Proceedings of the National Academy of Sciences 115 (43), 10845-10852, 2018 | 117 | 2018 |
| Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome C Shen, R Li, R Negro, J Cheng, SM Vora, TM Fu, A Wang, K He, ... Cell 184 (23), 5759-5774. e20, 2021 | 111 | 2021 |
| K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair † Pengda Liu1,2,*,†, Wenjian Gan1,*, Siyuan Su2,*, Arthur V. Hauenstein3 ... science signaling 11 (533), 2018 | 96 | 2018 |
| Structures of a complete human V-ATPase reveal mechanisms of its assembly L Wang, D Wu, CV Robinson, H Wu, TM Fu Molecular cell 80 (3), 501-511. e3, 2020 | 95 | 2020 |
| Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold P Fontana, Y Dong, X Pi, AB Tong, CW Hecksel, L Wang, TM Fu, ... Science 376 (6598), eabm9326, 2022 | 91 | 2022 |
| Molecular mechanism for NLRP6 inflammasome assembly and activation C Shen, A Lu, WJ Xie, J Ruan, R Negro, EH Egelman, TM Fu, H Wu Proceedings of the National Academy of Sciences 116 (6), 2052-2057, 2019 | 89 | 2019 |
| Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion SM Vora, P Fontana, T Mao, V Leger, Y Zhang, TM Fu, J Lieberman, ... Proceedings of the National Academy of Sciences 119 (9), e2117198119, 2022 | 68 | 2022 |
| SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism M Shi, L Wang, P Fontana, S Vora, Y Zhang, TM Fu, J Lieberman, H Wu BioRxiv, 2020 | 67 | 2020 |
| Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions A Lu, V Kabaleeswaran, T Fu, VG Magupalli, H Wu Journal of molecular biology 426 (7), 1420-1427, 2014 | 57 | 2014 |
| Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes L Robert Hollingsworth, L David, Y Li, AR Griswold, J Ruan, H Sharif, ... Nature communications 12 (1), 189, 2021 | 53 | 2021 |
| Mechanism of ubiquitin transfer promoted by TRAF6 TM Fu, C Shen, Q Li, P Zhang, H Wu Proceedings of the National Academy of Sciences 115 (8), 1783-1788, 2018 | 41 | 2018 |
Hao WuAsa and Patricia Springer Professor, Boston Children's Hospital and Harvard Medical School在 crystal.harvard.edu 的电子邮件经过验证
