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Ping-Chung Chen, Ph.D.
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Enhancement of proteasome activity by a small-molecule inhibitor of USP14
BH Lee, MJ Lee, S Park, DC Oh, S Elsasser, PC Chen, C Gartner, ...
Nature 467 (7312), 179-184, 2010
9962010
Deep multilayer brain proteomics identifies molecular networks in Alzheimer’s disease progression
B Bai, X Wang, Y Li, PC Chen, K Yu, KK Dey, JM Yarbro, X Han, BM Lutz, ...
Neuron 105 (6), 975-991. e7, 2020
3502020
U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s disease
B Bai, CM Hales, PC Chen, Y Gozal, EB Dammer, JJ Fritz, X Wang, Q Xia, ...
Proceedings of the National Academy of Sciences 110 (41), 16562-16567, 2013
3022013
Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3, 3 ‘-digallate,(−)-epigallocatechin-3-gallate, and propyl …
JK Lin, PC Chen, CT Ho, SY Lin-Shiau
Journal of Agricultural and Food Chemistry 48 (7), 2736-2743, 2000
2502000
The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions
PC Chen, LN Qin, XM Li, BJ Walters, JA Wilson, L Mei, SM Wilson
Journal of Neuroscience 29 (35), 10909-10919, 2009
1342009
Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease
H Wang, KK Dey, PC Chen, Y Li, M Niu, JH Cho, X Wang, B Bai, Y Jiao, ...
Molecular neurodegeneration 15, 1-20, 2020
1282020
Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease
KK Dey, H Wang, M Niu, B Bai, X Wang, Y Li, JH Cho, H Tan, A Mishra, ...
Clinical proteomics 16, 1-12, 2019
1132019
Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
B Bai, D Vanderwall, Y Li, X Wang, S Poudel, H Wang, KK Dey, PC Chen, ...
Molecular neurodegeneration 16 (1), 55, 2021
1122021
Ubiquitin homeostasis is critical for synaptic development and function
PC Chen, BJ Bhattacharyya, J Hanna, H Minkel, JA Wilson, D Finley, ...
Journal of Neuroscience 31 (48), 17505-17513, 2011
1102011
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity
BJ Walters, SL Campbell, PC Chen, AP Taylor, DG Schroeder, ...
Molecular and Cellular Neuroscience 39 (4), 539-548, 2008
862008
Neuronal ubiquitin homeostasis
J Hallengren, PC Chen, SM Wilson
Cell biochemistry and biophysics 67, 67-73, 2013
742013
Hypotriglyceridemic effect of Anka (a fermented rice product of Monascus sp.) in rats
IK Wang, SY Lin-Shiau, PC Chen, JK Lin
Journal of agricultural and food chemistry 48 (8), 3183-3189, 2000
532000
Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction.
JH Vaden, BJ Bhattacharyya, PC Chen, JA Watson, AG Marshall, ...
Molecular Neurodegeneration 10 (3), doi:10.1186/1750-1326-10-3, 2015
492015
Sequential elution interactome analysis of the mind bomb 1 ubiquitin ligase reveals a novel role in dendritic spine outgrowth
J Mertz, H Tan, V Pagala, B Bai, PC Chen, Y Li, JH Cho, T Shaw, X Wang, ...
Molecular & Cellular Proteomics 14 (7), 1898-1910, 2015
482015
Transgenic rescue of ataxia mice reveals a male-specific sterility defect
S Crimmins, M Sutovsky, PC Chen, A Huffman, C Wheeler, DA Swing, ...
Developmental biology 325 (1), 33-42, 2009
432009
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy
NM Badders, A Korff, HC Miranda, PK Vuppala, RB Smith, BJ Winborn, ...
Nature medicine 24 (4), 427-437, 2018
392018
Usp14 deficiency increases tau phosphorylation without altering tau degradation or causing tau-dependent deficits
YN Jin, PC Chen, JA Watson, BJ Walters, SE Phillips, K Green, R Schmidt, ...
PloS one 7 (10), e47884, 2012
342012
Integrated approaches for analyzing U1-70K cleavage in Alzheimer’s disease
B Bai, PC Chen, CM Hales, Z Wu, V Pagala, AA High, AI Levey, JJ Lah, ...
Journal of proteome research 13 (11), 4526-4534, 2014
292014
Quantitative proteomics to decipher ubiquitin signaling
PC Chen, CH Na, J Peng
Amino acids 43, 1049-1060, 2012
282012
CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology
W Su, J Saravia, I Risch, S Rankin, C Guy, NM Chapman, H Shi, Y Sun, ...
Nature immunology 24 (10), 1735-1747, 2023
262023
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