3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice AD Rathnayake, J Zheng, Y Kim, KD Perera, S Mackin, DK Meyerholz, ... Science translational medicine 12 (557), eabc5332, 2020 | 226 | 2020 |
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element ACG Kankanamalage, Y Kim, VC Damalanka, AD Rathnayake, AR Fehr, ... European journal of medicinal chemistry 150, 334-346, 2018 | 114 | 2018 |
Antiviral drug discovery: norovirus proteases and development of inhibitors KO Chang, Y Kim, S Lovell, AD Rathnayake, WC Groutas Viruses 11 (2), 197, 2019 | 81 | 2019 |
Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease CS Dampalla, Y Kim, N Bickmeier, AD Rathnayake, HN Nguyen, J Zheng, ... Journal of Medicinal Chemistry, 2021 | 48 | 2021 |
Protease inhibitors broadly effective against feline, ferret and mink coronaviruses KD Perera, ACG Kankanamalage, AD Rathnayake, A Honeyfield, ... Antiviral Research 160, 79-86, 2018 | 42 | 2018 |
Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor KD Perera, AD Rathnayake, H Liu, NC Pedersen, WC Groutas, KO Chang, ... Veterinary microbiology 237, 108398, 2019 | 35 | 2019 |
Structure-guided design of potent inhibitors of SARS-CoV-2 3CL protease: structural, biochemical, and cell-based studies CS Dampalla, AD Rathnayake, KD Perera, ARM Jesri, HN Nguyen, ... Journal of medicinal chemistry 64 (24), 17846-17865, 2021 | 32 | 2021 |
Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors ACG Kankanamalage, Y Kim, AD Rathnayake, VC Damalanka, ... European journal of medicinal chemistry 126, 502-516, 2017 | 26 | 2017 |
Structure-guided design of potent spirocyclic inhibitors of severe acute respiratory syndrome coronavirus-2 3C-like protease CS Dampalla, AD Rathnayake, AC Galasiti Kankanamalage, Y Kim, ... Journal of Medicinal Chemistry 65 (11), 7818-7832, 2022 | 23 | 2022 |
Design, synthesis, and evaluation of novel prodrugs of transition state inhibitors of norovirus 3CL protease AC Galasiti Kankanamalage, Y Kim, AD Rathnayake, KR Alliston, ... Journal of Medicinal Chemistry 60 (14), 6239-6248, 2017 | 22 | 2017 |
New measurements of the beam-normal single spin asymmetry in elastic electron scattering over a range of spin-0 nuclei D Adhikari, H Albataineh, D Androic, K Aniol, DS Armstrong, T Averett, ... Physical review letters 128 (14), 142501, 2022 | 21 | 2022 |
Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease VC Damalanka, Y Kim, ACG Kankanamalage, AD Rathnayake, ... European journal of medicinal chemistry 143, 881-890, 2018 | 16 | 2018 |
Organic Reaction Mechanisms, Selected Problems, and Solutions WC Groutas, AD Rathnayake CRC Press, 2023 | 15 | 2023 |
Structure-guided optimization of dipeptidyl inhibitors of norovirus 3CL protease AD Rathnayake, Y Kim, CS Dampalla, HN Nguyen, ARM Jesri, ... Journal of Medicinal Chemistry 63 (20), 11945-11963, 2020 | 15 | 2020 |
Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease AC Galasiti Kankanamalage, PM Weerawarna, AD Rathnayake, Y Kim, ... Proteins: Structure, Function, and Bioinformatics 87 (7), 579-587, 2019 | 12 | 2019 |
Broad-spectrum cyclopropane-based inhibitors of coronavirus 3C-like proteases: biochemical, structural, and virological studies CS Dampalla, HN Nguyen, AD Rathnayake, Y Kim, KD Perera, ... ACS Pharmacology & Translational Science 6 (1), 181-194, 2022 | 9 | 2022 |
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice. Sci Transl Med 12: eabc5332 AD Rathnayake, J Zheng, Y Kim, KD Perera, S Mackin, DK Meyerholz, ... | 7 | 2020 |
Determination of in-vitro Equivalence of Paracetamol Tablets AD Rathnayake, U Mannapperuma, D Thambawita, KPB Herath, ... International Journal of Multidisciplinary Studies 1 (1), 75-83, 2016 | 6 | 2016 |
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice. Sci Transl Med. 2020; 12 (557) AD Rathnayake, J Zheng, Y Kim, KD Perera, S Mackin, DK Meyerholz, ... Epub 2020/08/05. doi: 10.1126/scitranslmed. abc5332. PubMed PMID: 32747425, 0 | 6 | |
A Direct Detection Search for Hidden Sector New Particles in the 3-60 MeV Mass Range A Ahmidouch, S Davis, A Gasparian, TJ Hague, S Mtingwa, R Pedroni, ... arXiv preprint arXiv:2108.13276, 2021 | 5 | 2021 |