| Protein tyrosine phosphatases as potential therapeutic targets R He, Z Yu, R Zhang, Z Zhang Acta pharmacologica sinica 35 (10), 1227-1246, 2014 | 351 | 2014 |
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) X Zhang, Y He, S Liu, Z Yu, ZX Jiang, Z Yang, Y Dong, SC Nabinger, ... Journal of medicinal chemistry 53 (6), 2482-2493, 2010 | 212 | 2010 |
| Therapeutic targeting of oncogenic tyrosine phosphatases R Frankson, ZH Yu, Y Bai, Q Li, RY Zhang, ZY Zhang Cancer research 77 (21), 5701-5705, 2017 | 175 | 2017 |
| Phase separation of disease-associated SHP2 mutants underlies MAPK hyperactivation G Zhu, J Xie, W Kong, J Xie, Y Li, L Du, Q Zheng, L Sun, M Guan, H Li, ... Cell 183 (2), 490-502. e18, 2020 | 152 | 2020 |
| Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations ZH Yu, J Xu, CD Walls, L Chen, S Zhang, R Zhang, L Wu, L Wang, S Liu, ... Journal of Biological Chemistry 288 (15), 10472-10482, 2013 | 138 | 2013 |
| Therapeutic potential of targeting the oncogenic SHP2 phosphatase LF Zeng, RY Zhang, ZH Yu, S Li, L Wu, AM Gunawan, BS Lane, RS Mali, ... Journal of medicinal chemistry 57 (15), 6594-6609, 2014 | 127 | 2014 |
| Regulatory mechanisms and novel therapeutic targeting strategies for protein tyrosine phosphatases ZH Yu, ZY Zhang Chemical reviews 118 (3), 1069-1091, 2018 | 101 | 2018 |
| Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold Y He, J Xu, ZH Yu, AM Gunawan, L Wu, L Wang, ZY Zhang Journal of medicinal chemistry 56 (3), 832-842, 2013 | 84 | 2013 |
| Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations ZH Yu, RY Zhang, CD Walls, L Chen, S Zhang, L Wu, S Liu, ZY Zhang Biochemistry 53 (25), 4136-4151, 2014 | 79 | 2014 |
| Selective interaction between tylophorine B and bulged DNA Z Xi, R Zhang, Z Yu, D Ouyang, R Huang Bioorganic & medicinal chemistry letters 15 (10), 2673-2677, 2005 | 74 | 2005 |
| A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes S Zhang, S Liu, R Tao, D Wei, L Chen, W Shen, ZH Yu, L Wang, ... Journal of the American Chemical Society 134 (43), 18116-18124, 2012 | 61 | 2012 |
| The interaction between tylophorine B and TMV RNA Z Xi, R Zhang, Z Yu, D Ouyang Bioorganic & medicinal chemistry letters 16 (16), 4300-4304, 2006 | 59 | 2006 |
| SHP2 phosphatase as a novel therapeutic target for melanoma treatment RY Zhang, ZH Yu, L Zeng, S Zhang, Y Bai, J Miao, L Chen, J Xie, ... Oncotarget 7 (45), 73817, 2016 | 57 | 2016 |
| Exploring the existing drug space for novel pTyr mimetic and SHP2 inhibitors R He, ZH Yu, RY Zhang, L Wu, AM Gunawan, BS Lane, JS Shim, LF Zeng, ... ACS medicinal chemistry letters 6 (7), 782-786, 2015 | 57 | 2015 |
| Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase Y Bai, ZH Yu, S Liu, L Zhang, RY Zhang, LF Zeng, S Zhang, ZY Zhang Cancer research 76 (16), 4805-4815, 2016 | 51 | 2016 |
| Development of a general quantum‐chemical descriptor for steric effects: density functional theory based QSAR study of herbicidal sulfonylurea analogues Z Xi, Z Yu, C Niu, S Ban, G Yang Journal of computational chemistry 27 (13), 1571-1576, 2006 | 50 | 2006 |
| SHP2 is a target of the immunosuppressant tautomycetin S Liu, Z Yu, X Yu, SX Huang, Y Luo, L Wu, W Shen, Z Yang, L Wang, ... Chemistry & biology 18 (1), 101-110, 2011 | 45 | 2011 |
| Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors Y He, LF Zeng, ZH Yu, R He, S Liu, ZY Zhang Bioorganic & medicinal chemistry 20 (6), 1940-1946, 2012 | 40 | 2012 |
| APOL1 risk variants, acute kidney injury, and death in participants with African ancestry hospitalized with COVID-19 from the Million Veteran Program AM Hung, SC Shah, AG Bick, Z Yu, HC Chen, CM Hunt, F Wendt, ... JAMA internal medicine 182 (4), 386-395, 2022 | 36 | 2022 |
| Antofine analogues can inhibit tobacco mosaic virus assembly through small‐molecule–RNA interactions S Gao, R Zhang, Z Yu, Z Xi ChemBioChem 13 (11), 1622-1627, 2012 | 35 | 2012 |
