| ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer S Hashimoto, S Furukawa, A Hashimoto, A Tsutaho, A Fukao, ... Proceedings of the National Academy of Sciences 116 (35), 17450-17459, 2019 | 114 | 2019 |
| Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer S Hashimoto, S Mikami, H Sugino, A Yoshikawa, A Hashimoto, ... Nature communications 7 (1), 10656, 2016 | 105 | 2016 |
| P53-and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance A Hashimoto, T Oikawa, S Hashimoto, H Sugino, A Yoshikawa, Y Otsuka, ... Journal of cell biology 213 (1), 81-95, 2016 | 64 | 2016 |
| Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma T Menju, S Hashimoto, A Hashimoto, Y Otsuka, H Handa, E Ogawa, ... PloS one 6 (9), e25301, 2011 | 58 | 2011 |
| ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance A Hashimoto, S Hashimoto, H Sugino, A Yoshikawa, Y Onodera, H Handa, ... Oncogenesis 5 (9), e259-e259, 2016 | 47 | 2016 |
| Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy R Kinoshita, JM Nam, YM Ito, KC Hatanaka, A Hashimoto, H Handa, ... PloS one 8 (10), e76791, 2013 | 30 | 2013 |
| Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure T Furihata, S Takada, N Kakutani, S Maekawa, M Tsuda, J Matsumoto, ... Communications biology 4 (1), 138, 2021 | 25 | 2021 |
| Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-Activated Protein Kinase-ɑ–Proliferator-Activated … J Matsumoto, S Takada, T Furihata, H Nambu, N Kakutani, S Maekawa, ... Circulation: Heart Failure 14 (1), e005890, 2021 | 25 | 2021 |
| Arid5a promotes immune evasion by augmenting tryptophan metabolism and chemokine expression G Parajuli, M Tekguc, JB Wing, A Hashimoto, D Okuzaki, T Hirata, ... Cancer immunology research 9 (8), 862-876, 2021 | 18 | 2021 |
| Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure S Takada, S Maekawa, T Furihata, N Kakutani, D Setoyama, K Ueda, ... Proceedings of the National Academy of Sciences 119 (41), e2203628119, 2022 | 17 | 2022 |
| Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity T Oikawa, Y Otsuka, Y Onodera, M Horikawa, H Handa, S Hashimoto, ... Scientific reports 8 (1), 1595, 2018 | 16 | 2018 |
| Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats T Koizumi, M Watanabe, T Yokota, M Tsuda, H Handa, J Koya, K Nishino, ... Frontiers in Cardiovascular Medicine 10, 1005408, 2023 | 14 | 2023 |
| Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer A Hashimoto, H Handa, S Hata, A Tsutaho, T Yoshida, S Hirano, ... Cell Communication and Signaling 19 (1), 54, 2021 | 14 | 2021 |
| Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both mesenchymal-and amoeboid-type invasion of cancer cells H Handa, A Hashimoto, S Hashimoto, H Sabe Small GTPases 9 (5), 420-426, 2018 | 14 | 2018 |
| Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model Y Otsuka, T Oikawa, H Yoshino, S Hashimoto, H Handa, H Yamamoto, ... Cell communication and signaling 16, 1-9, 2018 | 13 | 2018 |
| Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells H Handa, A Hashimoto, S Hashimoto, H Sugino, T Oikawa, H Sabe Cell communication and signaling 16, 1-8, 2018 | 9 | 2018 |
| A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling T Maemoto, Y Kitai, R Takahashi, H Shoji, S Yamada, S Takei, D Ito, ... Journal of Biological Chemistry 299 (1), 2023 | 4 | 2023 |
| Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma A Hashimoto, H Handa, S Hata, S Hashimoto Frontiers in Oncology 12, 1005566, 2022 | 3 | 2022 |
| Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery H Natsui, M Watanabe, T Yokota, S Tsuneta, Y Fumoto, H Handa, ... Physiological Reports 12 (6), e15957, 2024 | 2 | 2024 |
| Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults R Shirakawa, T Nakajima, A Yoshimura, Y Kawahara, C Orito, M Yamane, ... Scientific reports 13 (1), 5203, 2023 | 2 | 2023 |
Tsukasa OikawaHokkaido UniversityVerified email at med.hokudai.ac.jp
