Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads. SE Salmon, KS Lam, M Lebl, A Kandola, PS Khattri, S Wade, M Patek, ... Proceedings of the National Academy of Sciences 90 (24), 11708-11712, 1993 | 166 | 1993 |
Safety-catch anchoring linkage for synthesis of peptide amides by Boc/Fmoc strategy M Patek, M Lebl Tetrahedron letters 32 (31), 3891-3894, 1991 | 113 | 1991 |
A Convenient Preparation of Monosubstituted/V,/V'-di (Boc)-Protected Guanidines B Drake, M Patek, M Lebl | 110 | 1994 |
Molecularly imprinted nanoreactors for regioselective huisgen 1, 3-dipolar cycloaddition reaction H Zhang, T Piacham, M Drew, M Patek, K Mosbach, L Ye Journal of the American Chemical Society 128 (13), 4178-4179, 2006 | 102 | 2006 |
Solid-phase synthesis of “small” organic molecules based on thiazolidine scaffold M Pátek, B Drake, M Lebl Tetrahedron letters 36 (13), 2227-2230, 1995 | 94 | 1995 |
Solid-phase synthesis of heterocycles containing an 1-acyl-3-oxopiperazine skeleton T Vojkovský, A Weichsel, M Pátek The Journal of Organic Chemistry 63 (10), 3162-3163, 1998 | 93 | 1998 |
Multiple release of equimolar amounts of peptides from a polymeric carrier using orthogonal linkage‐cleavage chemistry M LEBL, M PÁTEK, P KOČIŠ, V KRCHŇÁK, VJ HRUBY, SE SALMON, ... International Journal of Peptide and Protein Research 41 (2), 201-203, 1993 | 90 | 1993 |
A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time YC Li, LW Rodewald, C Hoppmann, ET Wong, S Lebreton, P Safar, ... Cell reports 9 (5), 1946-1958, 2014 | 87 | 2014 |
Discovery of a novel, potent, and specific family of factor Xa inhibitors via combinatorial chemistry JA Ostrem, F Al-Obeidi, P Safar, A Safarova, SK Stringer, M Patek, ... Biochemistry 37 (4), 1053-1059, 1998 | 86 | 1998 |
All-cis cyclopentane scaffolding for combinatorial solid phase synthesis of small non-peptide compounds M Pátek, B Drake, M Lebl Tetrahedron letters 35 (49), 9169-9172, 1994 | 65 | 1994 |
Safety‐catch and multiply cleavable linkers in solid‐phase synthesis M Patek, M Lebl Peptide Science 47 (5), 353-363, 1998 | 61 | 1998 |
7-substituted aza-indazoles, compositions containing same, production method and use thereof K Bjergarde, A Nair, M Patek, M Ackerman-berrier, M Smrcina, E Bacque, ... US Patent 8,058,290, 2011 | 58 | 2011 |
Preparative separation of mixtures by mass spectrometry PS Mayer, F Tureček, HN Lee, AA Scheidemann, TN Olney, ... Analytical chemistry 77 (14), 4378-4384, 2005 | 43 | 2005 |
Preparative separation of mixtures by mass spectrometry F Turecek, A Scheidemann, T Olney, FJ Schumacher, M Smrcina, P Strop, ... US Patent 6,750,448, 2004 | 39 | 2004 |
Novel compounds targeting neuropilin receptor 1 with potential to interfere with SARS-CoV-2 virus entry S Perez-Miller, M Patek, A Moutal, P Duran, CR Cabel, CA Thorne, ... ACS chemical neuroscience 12 (8), 1299-1312, 2021 | 35 | 2021 |
Solid-phase synthesis of substituted guanidines using a novel acid labile linker M Pátek, M Smrčina, E Nakanishi, H Izawa Journal of Combinatorial Chemistry 2 (4), 370-377, 2000 | 35 | 2000 |
Bis-Allylic Templates for Pd (0)-Catalyzed Solid Phase Synthesis of Tertiary Amines. Z Flegelová, M Pátek The Journal of Organic Chemistry 61 (19), 6735-6738, 1996 | 32 | 1996 |
Apparatus and method for synthesizing combinational libraries M Patek, S Pavel, M Smrcina, E Wegrzyniak, P Strop, GA Flynn, SA Baum US Patent 6,541,211, 2003 | 30 | 2003 |
Reversal of peripheral neuropathic pain by the small-molecule natural product Physalin F via block of CaV2. 3 (R-type) and CaV2. 2 (N-type) voltage-gated calcium channels Z Shan, S Cai, J Yu, Z Zhang, TGM Vallecillo, MJ Serafini, AM Thomas, ... ACS chemical neuroscience 10 (6), 2939-2955, 2019 | 29 | 2019 |
Multistep deprotection for peptide chemistry M PATEK International Journal of Peptide and Protein Research 42 (2), 97-117, 1993 | 28 | 1993 |