Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics NAJ Krentz, AL Gloyn Nature Reviews Endocrinology 16 (4), 202-212, 2020 | 115 | 2020 |
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion OP Dwivedi, M Lehtovirta, B Hastoy, V Chandra, NAJ Krentz, S Kleiner, ... Nature genetics 51 (11), 1596-1606, 2019 | 112 | 2019 |
Single-cell transcriptome profiling of mouse and hESC-derived pancreatic progenitors NAJ Krentz, MYY Lee, EE Xu, SLJ Sproul, A Maslova, S Sasaki, FC Lynn Stem cell reports 11 (6), 1551-1564, 2018 | 111 | 2018 |
Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors NAJ Krentz, D van Hoof, Z Li, A Watanabe, M Tang, C Nian, MS German, ... Developmental cell 41 (2), 129-142. e6, 2017 | 93 | 2017 |
TALEN/CRISPR-Mediated eGFP Knock-In Add-On at the OCT4 Locus Does Not Impact Differentiation of Human Embryonic Stem Cells towards Endoderm NAJ Krentz, C Nian, FC Lynn PloS one 9 (12), e114275, 2014 | 43 | 2014 |
Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells PV Sabatini, NAJ Krentz, B Zarrouki, CY Westwell-Roper, C Nian, RA Uy, ... Diabetes 62 (8), 2808-2820, 2013 | 40 | 2013 |
SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models EE Xu, NAJ Krentz, S Tan, SZ Chow, M Tang, C Nian, FC Lynn Diabetologia 58, 1013-1023, 2015 | 36 | 2015 |
Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering NAJ Krentz, LD Shea, MO Huising, JAM Shaw The Lancet Diabetes & Endocrinology 9 (10), 708-724, 2021 | 25 | 2021 |
TrxG complex catalytic and non-catalytic activity play distinct roles in pancreas progenitor specification and differentiation SA Campbell, CL McDonald, NAJ Krentz, FC Lynn, BG Hoffman Cell reports 28 (7), 1830-1844. e6, 2019 | 13 | 2019 |
77-Ins2 Gene Bursting Activity Defines a Mature β-Cell State H Modi, J Chu, S Skovsø, C Ellis, NAJ Krentz, Y Zhao, HH Cen, ... Canadian Journal of Diabetes 44 (7), S31, 2020 | 10 | 2020 |
A regulatory network controls nephrocan expression and midgut patterning J Hou, W Wei, RS Saund, P Xiang, TJ Cunningham, Y Yi, O Alder, ... Development 141 (19), 3772-3781, 2014 | 8 | 2014 |
Dynamic Ins2 Gene Activity Defines β-Cell Maturity States CMJ Chu, H Modi, C Ellis, NAJ Krentz, S Skovsø, YB Zhao, H Cen, ... Diabetes 71 (12), 2612-2631, 2022 | 6 | 2022 |
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression KK Mattis, NAJ Krentz, C Metzendorf, F Abaitua, AF Spigelman, H Sun, ... Diabetologia 66 (4), 674-694, 2023 | 5 | 2023 |
PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development HH Lau, NAJ Krentz, F Abaitua, M Perez-Alcantara, JW Chan, J Ajeian, ... Nature Communications 14 (1), 6119, 2023 | 3 | 2023 |
Improvements in stem cell to beta-cell differentiation for the treatment of diabetes NAJ Krentz Journal of Immunology and Regenerative Medicine 12, 100043, 2021 | 3 | 2021 |
Dynamic Ins2 gene activity defines β cell maturity states H Modi, CM Jamie Chu, S Skovsø, C Ellis, NAJ Krentz, YB Zhao, H Cen, ... bioRxiv, 702589, 2019 | 2 | 2019 |
Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model M Jaffredo, NAJ Krentz, B Champon, CE Duff, S Nawaz, N Beer, ... bioRxiv, 2023 | 1 | 2023 |
Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding TA Alghamdi, NAJ Krentz, N Smith, AF Spigelman, V Rajesh, A Jha, ... Molecular Metabolism 66, 101621, 2022 | 1 | 2022 |
PAX4 loss of function alters human endocrine cell development and influences diabetes risk HH Lau, NAJ Krentz, F Abaitua, M Perez-Alcantara, JW Chan, J Ajeian, ... bioRxiv, 2022.05. 15.491987, 2022 | 1 | 2022 |
Imaging Ins2 gene activity and single-cell RNA sequencing reveal heterogeneous beta cell states H Modi, H Cen, S Skovso, X Hu, N Krentz, D Dionne, S Xuan, M Huising, ... DIABETOLOGIA 61, S17-S17, 2018 | 1 | 2018 |