| Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance A Gangjee, Y Zhao, L Lin, S Raghavan, EG Roberts, AL Risinger, ... Journal of medicinal chemistry 53 (22), 8116-8128, 2010 | 86 | 2010 |
| Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5-b]indoles as Receptor Tyrosine Kinase … A Gangjee, N Zaware, S Raghavan, M Ihnat, S Shenoy, RL Kisliuk Journal of medicinal chemistry 53 (4), 1563-1578, 2010 | 83 | 2010 |
| The design and discovery of water soluble 4-substituted-2, 6-dimethylfuro [2, 3-d] pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting … X Zhang, S Raghavan, M Ihnat, JE Thorpe, BC Disch, A Bastian, ... Bioorganic & medicinal chemistry 22 (14), 3753-3772, 2014 | 57 | 2014 |
| 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human … L Wang, A Wallace, S Raghavan, SM Deis, MR Wilson, S Yang, L Polin, ... Journal of medicinal chemistry 58 (17), 6938-6959, 2015 | 55 | 2015 |
| Discovery of 5-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4 … S Mitchell-Ryan, Y Wang, S Raghavan, MP Ravindra, E Hales, S Orr, ... Journal of medicinal chemistry 56 (24), 10016-10032, 2013 | 51 | 2013 |
| Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles A Gangjee, OA Namjoshi, S Raghavan, SF Queener, RL Kisliuk, V Cody Journal of medicinal chemistry 56 (11), 4422-4441, 2013 | 51 | 2013 |
| Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and … LK Golani, A Wallace-Povirk, SM Deis, J Wong, J Ke, X Gu, S Raghavan, ... Journal of medicinal chemistry 59 (17), 7856-7876, 2016 | 44 | 2016 |
| The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2, 6-dimethylfuro [2, 3-d] pyrimidines as multi-targeted receptor tyrosine kinase … X Zhang, S Raghavan, M Ihnat, E Hamel, C Zammiello, A Bastian, ... Bioorganic & medicinal chemistry 23 (10), 2408-2423, 2015 | 41 | 2015 |
| Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α … LK Golani, C George, S Zhao, S Raghavan, S Orr, A Wallace, MR Wilson, ... Journal of medicinal chemistry 57 (19), 8152-8166, 2014 | 37 | 2014 |
| Novel 5-Substituted Pyrrolo[2,3-d]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide … Y Wang, S Mitchell-Ryan, S Raghavan, C George, S Orr, Z Hou, ... Journal of medicinal chemistry 58 (3), 1479-1493, 2015 | 35 | 2015 |
| Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo [2, 3-d] pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents A Gangjee, Y Zhao, S Raghavan, MA Ihnat, BC Disch Bioorganic & medicinal chemistry 18 (14), 5261-5273, 2010 | 35 | 2010 |
| Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-microtubule Agent N-(4-Methoxyphenyl)-N, 2, 6-trimethyl-6, 7-dihydro-5 H … A Gangjee, Y Zhao, S Raghavan, CC Rohena, SL Mooberry, E Hamel Journal of medicinal chemistry 56 (17), 6829-6844, 2013 | 31 | 2013 |
| Tumor-Targeting with Novel Non-Benzoyl 6-Substituted Straight Chain Pyrrolo[2,3-d]pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and Inhibition … Y Wang, C Cherian, S Orr, S Mitchell-Ryan, Z Hou, S Raghavan, ... Journal of medicinal chemistry 56 (21), 8684-8695, 2013 | 30 | 2013 |
| ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase N Satani, YH Lin, N Hammoudi, S Raghavan, DK Georgiou, FL Muller PLOS One 11 (12), e0168739, 2016 | 29 | 2016 |
| Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido [4, 5-b] indole-2, 4-diamines as vascular endothelial growth factor receptor-2 inhibitors and … A Gangjee, N Zaware, S Raghavan, BC Disch, JE Thorpe, A Bastian, ... Bioorganic & medicinal chemistry 21 (7), 1857-1864, 2013 | 29 | 2013 |
| N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo [2, 3-d] pyrimidines as potent multiple receptor tyrosine kinase inhibitors: Design, synthesis, and in vivo evaluation A Gangjee, N Zaware, S Raghavan, J Yang, JE Thorpe, MA Ihnat Bioorganic & medicinal chemistry 20 (7), 2444-2454, 2012 | 28 | 2012 |
| Synthesis of N4-(substituted phenyl)-N4-alkyl/desalkyl-9H-pyrimido [4, 5-b] indole-2, 4-diamines and identification of new microtubule disrupting compounds that are effective … A Gangjee, N Zaware, RKV Devambatla, S Raghavan, CD Westbrook, ... Bioorganic & medicinal chemistry 21 (4), 891-902, 2013 | 26 | 2013 |
| The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues F Pisaneschi, YH Lin, PG Leonard, N Satani, VC Yan, N Hammoudi, ... Molecules 24 (13), 2510, 2019 | 13 | 2019 |
| PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in … M Sharpe, S Raghavan, D Baskin Oncotarget 9 (35), 23923-23943, 2018 | 8 | 2018 |
| A” Clickable” Probe for Active MGMT in Glioblastoma Demonstrates Two Discrete Populations of MGMT S Raghavan, DS Baskin, MA Sharpe Cancers 12 (2), 453, 2020 | 7 | 2020 |
Nilesh ZawareIcahn School of Medicine at Mount SinaiVerified email at mssm.edu
