An update on MDMX and dual MDM2/X inhibitors M Espadinha, V Barcherini, EA Lopes, MMM Santos Current topics in medicinal chemistry 18 (8), 647-660, 2018 | 49 | 2018 |
Small molecules targeting mutant p53: A promising approach for cancer treatment EA Lopes, S Gomes, L Saraiva, MMM Santos Current Medicinal Chemistry 26 (41), 7323-7336, 2019 | 19 | 2019 |
Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors M Espadinha, EA Lopes, V Marques, JD Amaral, DJVA Dos Santos, ... European Journal of Medicinal Chemistry 241, 114637, 2022 | 18 | 2022 |
Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity EA Lopes, R Mestre, D Fontinha, J Legac, JV Pei, M Sanches-Vaz, M Mori, ... European Journal of Medicinal Chemistry 236, 114324, 2022 | 10 | 2022 |
Potency and Selectivity Optimization of Tryptophanol‐Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer V Barcherini, J Almeida, EA Lopes, M Wang, D Magalhaes e Silva, M Mori, ... ChemMedChem 16 (1), 250-258, 2021 | 10 | 2021 |
Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis JB Loureiro, R Ribeiro, N Nazareth, T Ferreira, EA Lopes, A Gama, ... Pharmacological Research 175, 106026, 2022 | 6 | 2022 |
Pharmacological treatment of malaria EA Lopes, MMM Santos, M Mori Antiprotozoal Drug Development and Delivery, 219-240, 2021 | 4 | 2021 |
Antimalarial drugs: what’s new in the patents? EA Lopes, MMM Santos, M Mori Expert Opinion on Therapeutic Patents 33 (3), 151-168, 2023 | 3 | 2023 |
Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells G Girst, EA Lopes, LM Gonçalves, M Espadinha, N Kúsz, HC Wang, ... RSC Medicinal Chemistry 14 (9), 1778-1786, 2023 | 2 | 2023 |
Synthesis of Spirooxindoles by Multicomponent Reactions EA Lopes, MMM Santos Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, 225-247, 2020 | 2 | 2020 |
Protoflavone–spirooxindole hybrids exhibit promising, increased antitumor activity G Girst, EA Lopes, M Espadinha, LM Gonçalves, MMM Santos, A Hunyadi Planta Medica 87 (15), PC9-21, 2021 | | 2021 |
Chemoprevention of ultraviolet B radiation-induced skin cancer with the mutant p53 reactivator SLMP53-2 JB Loureiro, R Ribeiro, TF Nair Nazareth, EA Lopes, A Quaresma, ... MDPI, 2021 | | 2021 |
Optimizing the oxazoloisoindolinone family: identification and biological evaluation of a potent and selective indole-based p53 activator in human colorectal cancer V Barcherini, J Almeida, EA Lopes, M Wang, DM e Silva, M Mori, S Wang, ... MDPI, 2020 | | 2020 |
Hybrid molecules of protoflavones and indole derivatives with selective cytotoxicity against triple-negative breast cancer cells G Girst, EA Lopes, LM Gonçalves, M Espadinha, N Kúsz, HC Wang, ... | | |
Enhancing anticancer activity of spiropyrazoline oxindoles by disrupting p53-MDMs PPIs EA Lopes, M Espadinha, M Mori, M Botta, MMM Santos | | |