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Elizabeth A. Lopes
Elizabeth A. Lopes
iMed.Ulisboa - Research Institutes for Medicines
Email confirmado em campus.ul.pt - Página inicial
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An update on MDMX and dual MDM2/X inhibitors
M Espadinha, V Barcherini, EA Lopes, MMM Santos
Current topics in medicinal chemistry 18 (8), 647-660, 2018
492018
Small molecules targeting mutant p53: A promising approach for cancer treatment
EA Lopes, S Gomes, L Saraiva, MMM Santos
Current Medicinal Chemistry 26 (41), 7323-7336, 2019
192019
Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors
M Espadinha, EA Lopes, V Marques, JD Amaral, DJVA Dos Santos, ...
European Journal of Medicinal Chemistry 241, 114637, 2022
182022
Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity
EA Lopes, R Mestre, D Fontinha, J Legac, JV Pei, M Sanches-Vaz, M Mori, ...
European Journal of Medicinal Chemistry 236, 114324, 2022
102022
Potency and Selectivity Optimization of Tryptophanol‐Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer
V Barcherini, J Almeida, EA Lopes, M Wang, D Magalhaes e Silva, M Mori, ...
ChemMedChem 16 (1), 250-258, 2021
102021
Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis
JB Loureiro, R Ribeiro, N Nazareth, T Ferreira, EA Lopes, A Gama, ...
Pharmacological Research 175, 106026, 2022
62022
Pharmacological treatment of malaria
EA Lopes, MMM Santos, M Mori
Antiprotozoal Drug Development and Delivery, 219-240, 2021
42021
Antimalarial drugs: what’s new in the patents?
EA Lopes, MMM Santos, M Mori
Expert Opinion on Therapeutic Patents 33 (3), 151-168, 2023
32023
Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells
G Girst, EA Lopes, LM Gonçalves, M Espadinha, N Kúsz, HC Wang, ...
RSC Medicinal Chemistry 14 (9), 1778-1786, 2023
22023
Synthesis of Spirooxindoles by Multicomponent Reactions
EA Lopes, MMM Santos
Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, 225-247, 2020
22020
Protoflavone–spirooxindole hybrids exhibit promising, increased antitumor activity
G Girst, EA Lopes, M Espadinha, LM Gonçalves, MMM Santos, A Hunyadi
Planta Medica 87 (15), PC9-21, 2021
2021
Chemoprevention of ultraviolet B radiation-induced skin cancer with the mutant p53 reactivator SLMP53-2
JB Loureiro, R Ribeiro, TF Nair Nazareth, EA Lopes, A Quaresma, ...
MDPI, 2021
2021
Optimizing the oxazoloisoindolinone family: identification and biological evaluation of a potent and selective indole-based p53 activator in human colorectal cancer
V Barcherini, J Almeida, EA Lopes, M Wang, DM e Silva, M Mori, S Wang, ...
MDPI, 2020
2020
Hybrid molecules of protoflavones and indole derivatives with selective cytotoxicity against triple-negative breast cancer cells
G Girst, EA Lopes, LM Gonçalves, M Espadinha, N Kúsz, HC Wang, ...
Enhancing anticancer activity of spiropyrazoline oxindoles by disrupting p53-MDMs PPIs
EA Lopes, M Espadinha, M Mori, M Botta, MMM Santos
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