Development and characterization of hepatitis C virus genotype 1‐7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs JM Gottwein, TKH Scheel, TB Jensen, JB Lademann, JC Prentoe, ... Hepatology 49 (2), 364-377, 2009 | 434 | 2009 |
Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses JM Gottwein, TKH Scheel, AM Hoegh, JB Lademann, J Eugen–Olsen, ... Gastroenterology 133 (5), 1614-1626, 2007 | 243 | 2007 |
Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization TKH Scheel, JM Gottwein, TB Jensen, JC Prentoe, AM Hoegh, HJ Alter, ... Proceedings of the National Academy of Sciences 105 (3), 997-1002, 2008 | 234 | 2008 |
MicroRNA-122 antagonism against hepatitis C virus genotypes 1–6 and reduced efficacy by host RNA insertion or mutations in the HCV 5′ UTR YP Li, JM Gottwein, TK Scheel, TB Jensen, J Bukh Proceedings of the National Academy of Sciences 108 (12), 4991-4996, 2011 | 231 | 2011 |
p-ANCAs in autoimmune liver disorders recognise human β-tubulin isotype 5 and cross-react with microbial protein FtsZ B Terjung, J Söhne, B Lechtenberg, J Gottwein, M Muennich, V Herzog, ... Gut 59 (6), 808-816, 2010 | 192 | 2010 |
Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization J Prentoe, TB Jensen, P Meuleman, SBN Serre, TKH Scheel, ... Journal of virology 85 (5), 2224-2234, 2011 | 167 | 2011 |
Recombinant HCV variants with NS5A from genotypes 1–7 have different sensitivities to an NS5A inhibitor but not interferon-α TKH Scheel, JM Gottwein, LS Mikkelsen, TB Jensen, J Bukh Gastroenterology 140 (3), 1032-1042. e6, 2011 | 162 | 2011 |
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses JM Gottwein, TKH Scheel, TB Jensen, L Ghanem, J Bukh Gastroenterology 141 (3), 1067-1079, 2011 | 155 | 2011 |
Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system YP Li, S Ramirez, SB Jensen, RH Purcell, JM Gottwein, J Bukh Proceedings of the National Academy of Sciences 109 (48), 19757-19762, 2012 | 149 | 2012 |
Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells M Saeed, TKH Scheel, JM Gottwein, S Marukian, LB Dustin, J Bukh, ... Antimicrobial agents and chemotherapy 56 (10), 5365-5373, 2012 | 144 | 2012 |
Novel Infectious cDNA Clones of Hepatitis C Virus Genotype 3a (Strain S52) and 4a (Strain ED43): Genetic Analyses and In Vivo Pathogenesis Studies JM Gottwein, TKH Scheel, B Callendret, YP Li, HB Eccleston, RE Engle, ... Journal of virology 84 (10), 5277-5293, 2010 | 142 | 2010 |
Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems JM Gottwein, J Bukh Advances in virus research 71, 51-133, 2008 | 138 | 2008 |
Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: failure of homologous neutralizing-antibody treatment to control infection TB Jensen, JM Gottwein, TKH Scheel, AM Hoegh, J Eugen-Olsen, J Bukh The Journal of infectious diseases 198 (12), 1756-1765, 2008 | 133 | 2008 |
Protective Anti‐Helicobacter Immunity Is Induced with Aluminum Hydroxide or Complete Freund’s Adjuvant by Systemic Immunization JM Gottwein, TG Blanchard, OS Targoni, JC Eisenberg, BM Zagorski, ... The Journal of infectious diseases 184 (3), 308-314, 2001 | 120 | 2001 |
Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus JC Meunier, JM Gottwein, M Houghton, RS Russell, SU Emerson, J Bukh, ... Journal of Infectious Diseases 204 (8), 1186-1190, 2011 | 116 | 2011 |
Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system Y Zhou, KA Gammeltoft, LA Ryberg, LV Pham, HD Tjørnelund, A Binderup, ... Science Advances 8 (51), eadd7197, 2022 | 114 | 2022 |
Efficacy of NS5A inhibitors against hepatitis C virus genotypes 1–7 and escape variants JM Gottwein, LV Pham, LS Mikkelsen, L Ghanem, S Ramirez, TKH Scheel, ... Gastroenterology 154 (5), 1435-1448, 2018 | 109 | 2018 |
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains YP Li, S Ramirez, JM Gottwein, TKH Scheel, L Mikkelsen, RH Purcell, ... Proceedings of the National Academy of Sciences 109 (18), E1101-E1110, 2012 | 105 | 2012 |
Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified … JM Gottwein, TB Jensen, CK Mathiesen, P Meuleman, SBN Serre, ... Journal of virology 85 (17), 8913-8928, 2011 | 93 | 2011 |
In vitro efficacy of artemisinin-based treatments against SARS-CoV-2 Y Zhou, K Gilmore, S Ramirez, E Settels, KA Gammeltoft, LV Pham, ... Scientific Reports 11 (1), 14571, 2021 | 88 | 2021 |