Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism DP Dowling, NA Bruender, AP Young, RM McCarty, V Bandarian, ... Nature chemical biology 10 (2), 106-112, 2014 | 90 | 2014 |
Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine AP Young, V Bandarian Biochemistry 50 (49), 10573-10575, 2011 | 46 | 2011 |
Chemical and Biological Reduction of the Radical SAM Enzyme CPH4 Synthase NA Bruender, AP Young, V Bandarian Biochemistry 54 (18), 2903-2910, 2015 | 39 | 2015 |
Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine AP Young, V Bandarian Current opinion in chemical biology 17 (4), 613-618, 2013 | 27 | 2013 |
Mechanistic Studies of the Radical S-Adenosyl-l-methionine Enzyme 4-Demethylwyosine Synthase Reveal the Site of Hydrogen Atom Abstraction AP Young, V Bandarian Biochemistry 54 (23), 3569-3572, 2015 | 18 | 2015 |
Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1 TAJ Grell, AP Young, CL Drennan, V Bandarian 2018 140, 6842-6852, 0 | 17* | |
TYW1: A Radical SAM Enzyme Involved in the Biosynthesis of Wybutosine Bases AP Young, V Bandarian Methods in Enzymology 606, 119-153, 2018 | 16 | 2018 |
New role for radical SAM enzymes in the biosynthesis of thio (seleno) oxazole RiPP natural products JK Lewis, AS Jochimsen, SJ Lefave, AP Young, WM Kincannon, ... Biochemistry 60 (45), 3347-3361, 2021 | 13 | 2021 |
Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at its Physiological Role MT Nelp, AP Young, BM Stepanski, V Bandarian Biochemistry 56 (30), 3874-3876, 2017 | 13 | 2017 |
Eukaryotic TYW1 is a radical SAM flavoenzyme AP Young, V Bandarian Biochemistry 60 (27), 2179-2185, 2021 | 9 | 2021 |
Elucidation of the substrate of tRNA-modifying enzymes MnmEG leads to in vitro reconstitution of an evolutionarily conserved uridine hypermodification P Bommisetti, A Young, V Bandarian Journal of Biological Chemistry 298 (11), 2022 | 5 | 2022 |
Insertion of 4-Demethylwyosine in tRNAPhe Catalyzed by the Radical S-Adenosyl-l-methionine Enzyme TYW1 Entails Oxidative Cleavage of Pyruvate to Form CO2 AP Young, V Bandarian Biochemistry 61 (23), 2643-2647, 2022 | | 2022 |
Redox Mediated Modifications of tRNA Bases AP Young, V Bandarian Elsevier, 2020 | | 2020 |
Characterization of 4-demethylwyosine synthase, a radical S-adenosyl-L-methionine enzyme involved in the modification of tRNA AP Young The University of Arizona, 2016 | | 2016 |